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Nanomaterials
Special Issues
Nanoparticulate Platforms for Enhancing Immunotherapy
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Nanoparticulate Platforms for Enhancing Immunotherapy

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (1 October 2022) | Viewed by 4532

Special Issue Editors

Dr. Shiva Pathak

E-Mail Website
Guest Editor
Department of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA 94305, USA
Interests: drug delivery systems; novel immunosuppressive regimens for inducing transplant tolerance; biomaterials for drug and cell delivery; targeted drug delivery for cancer treatment
Dr. Shobha Regmi

E-Mail Website
Guest Editor
Department of Radiology, Stanford University, Stanford, CA 94305, USA
Interests: mesenchymal stem cell transplantation; nanoparticle–immune cell interactions; tolerance induction; biomaterials; drug delivery
Dr. Biki Gupta

E-Mail Website
Guest Editor
Division of Experimental Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Interests: nanoparticles; tumor chemotherapy; targeted drug delivery; immunosuppressive formulations for transplantation

Special Issue Information

Dear Colleagues,

Immunotherapy approaches either stimulate or suppress the immune system during pathological conditions for the benefits of recipients. Recently, different immunotherapy-based nanoparticulate platforms have received significant attention for the treatment of various diseases, including cancers, autoimmune disorders, infections, and tissue or organ transplantation related rejections. Undoubtedly, nanoparticle-based immunotherapies have shown promising therapeutic outcomes in both preclinical and clinical studies.

Various types of nanoparticles have been developed to improve cancer treatment outcomes by targeting different immunological cascades to boost the immune reaction, and they have been proved to exert minimal side effects compared to conventional therapies. In infectious diseases, nanoparticles can be used to activate cellular and humoral immunity to help the body to fight against infections. In autoimmunity and transplantation settings, the immunomodulatory nanoparticles can suppress immunity and induce antigen-specific tolerance to the grafts, and thus have a great potential to abrogate the life-threatening adverse effects associated with the conventional immunosuppressive agents.

The current Special Issue invites all types of articles on nanoparticle-based approaches for immunotherapy, particularly focused on but not limited to cancer immunotherapy, autoimmune diseases, infections, and transplantation. We welcome any original articles, review papers, and communications dealing with the use of nanoparticles for immunotherapy.

Dr. Shiva Pathak
Dr. Shobha Regmi
Dr. Biki Gupta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunomodulatory nanoparticles
  • targeted/local drug delivery
  • nanoparticle–immune cell interactions
  • immunotherapy for cancer diagnosis and treatment
  • checkpoint inhibition for cancer treatment
  • nanoparticles for autoimmune diseases and infections
  • nanoparticles for promoting immune tolerance

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Published Papers (2 papers)

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14 pages, 2922 KiB  
Article
Predicting Associations of miRNAs and Candidate Gastric Cancer Genes for Nanomedicine
by Aigul Akimniyazova, Anna Pyrkova, Vladimir Uversky and Anatoliy Ivashchenko
Nanomaterials 2021, 11(3), 691; https://doi.org/10.3390/nano11030691 - 10 Mar 2021
Cited by 5 | Viewed by 2172
Abstract
Nanoscale miRNAs regulate the synthesis of most human proteins involved in differentiation, proliferation, cell cycle, apoptosis, and other processes associated with the growth and the development of an organism. miRNAs also play a number of important roles in the development of gastric cancer. [...] Read more.
Nanoscale miRNAs regulate the synthesis of most human proteins involved in differentiation, proliferation, cell cycle, apoptosis, and other processes associated with the growth and the development of an organism. miRNAs also play a number of important roles in the development of gastric cancer. In this work, we studied the quantitative characteristics of miRNA interactions with 69 candidate gastric cancer genes using bioinformatics approaches. To this end, the MirTarget program was used, which determines the characteristics of miRNA binding to mRNA in the 5′UTR, CDS, and 3′UTR. Associations of miRNAs with alternative target genes and associations of genes with alternative miRNAs were established. The cluster organization of miRNA binding sites (BSs) in mRNA was revealed, leading to the emergence of miRNA competition for binding to the mRNA of a target gene. Groups of target genes with clusters of overlapping BSs include miR-5095, miR-619-5p, miR-1273 family, miR-466, ID01030.3p-miR, ID00436.3p-miR, miR-574-5p, and ID00470.5p-miR. In the defined associations of target genes and miRNAs, miRNA BSs are organized into clusters of multiple BSs, which facilitate the design and the development of a system of chips that can be used to control the state of miRNA and target genes associations in gastric cancer. Full article
(This article belongs to the Special Issue Nanoparticulate Platforms for Enhancing Immunotherapy)
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18 pages, 1089 KiB  
Systematic Review
Antifouling Strategies of Nanoparticles for Diagnostic and Therapeutic Application: A Systematic Review of the Literature
by Paolo Bevilacqua, Silvia Nuzzo, Enza Torino, Gerolama Condorelli, Marco Salvatore and Anna Maria Grimaldi
Nanomaterials 2021, 11(3), 780; https://doi.org/10.3390/nano11030780 - 18 Mar 2021
Cited by 33 | Viewed by 4135
Abstract
Nanoparticles (NPs) are promising platforms for the development of diagnostic and therapeutic tools. One of the main hurdle to their medical application and translation into the clinic is the fact that they accumulate in the spleen and liver due to opsonization and scavenging [...] Read more.
Nanoparticles (NPs) are promising platforms for the development of diagnostic and therapeutic tools. One of the main hurdle to their medical application and translation into the clinic is the fact that they accumulate in the spleen and liver due to opsonization and scavenging by the mononuclear phagocyte system. The “protein corona” controls the fate of NPs in vivo and becomes the interface with cells, influencing their physiological response like cellular uptake and targeting efficiency. For these reasons, the surface properties play a pivotal role in fouling and antifouling behavior of particles. Therefore, surface engineering of the nanocarriers is an extremely important issue for the design of useful diagnostic and therapeutic systems. In recent decades, a huge number of studies have proposed and developed different strategies to improve antifouling features and produce NPs as safe and performing as possible. However, it is not always easy to compare the various approaches and understand their advantages and disadvantages in terms of interaction with biological systems. Here, we propose a systematic study of literature with the aim of summarizing current knowledge on promising antifouling coatings to render NPs more biocompatible and performing for diagnostic and therapeutic purposes. Thirty-nine studies from 2009 were included and investigated. Our findings have shown that two main classes of non-fouling materials (i.e., pegylated and zwitterionic) are associated with NPs and their applications are discussed here highlighting pitfalls and challenges to develop biocompatible tools for diagnostic and therapeutic uses. In conclusion, although the complexity of biofouling strategies and the field is still young, the collective data selected in this review indicate that a careful tuning of surface moieties is a pivotal step to lead NPs through their future clinical applications. Full article
(This article belongs to the Special Issue Nanoparticulate Platforms for Enhancing Immunotherapy)
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