Nanotechnology and Nanomaterials in Biological Systems and Medicine

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 6627

Special Issue Editors


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Guest Editor
College of Engineering and Applied Sciences, Stony Brook University, Stony Brook, NY, USA
Interests: bone tissue engineering and regeneration; nanoparticle; ultrasound imaging; diagnosis and treatment; cellular and tissue biomechanics

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Guest Editor
The Engineering-Meets-Medicine Laboratory, Stony Brook University, Stony Brook, NY, USA
Interests: smart-biomaterials and nano-biomaterials; biodegradable or bioresorbable materials; regenerative medicine for cardiovascular and orthopedic applications; innovative drug delivery device and platform; aging and neurodegenerative diseases like Alzheimer’s
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Guest Editor
Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, USA
Interests: biomaterials; tissue engineering

Special Issue Information

Dear Colleagues,

Nanotechnology and nanomaterials have developed rapidly in the past two decades at an accelerated speed, in both basic sciences and application domains. Nanomaterials are characterized by their nanoscale size (referred to as a size of 10–9 m, i.e., in the range of 1 to 100 nm), volume, surface features, shape, synchronization, and function, with applications in chemistry, physics, mechanics, material sciences, and biological interactions.

Nanotechnology and nanomaterials are among the most promising technological developments of the 21st century. Nanomaterials are being applied in many fields as a new generation of technologies, such as in biomedical areas, particularly disease diagnosis and treatment. Their advanced physical and chemical features provide innovative solutions to overcome various obstacles and effectively deliver particles to regions of interest.

The aim of this Special Issue is to provide a platform for recent research outcomes related to nanomaterials in basic biomedical sciences, the mechanisms of nanoparticle cellular and tissue regeneration and degeneration, new devices utilizing nanomaterials for diagnosis and therapeutics, and their potential applications in various diseases in human and other species. These will shed new light on the subject, leading to new basic science directions and clinical applications based on nanomaterials.

Prof. Dr. Yi-Xian Qin
Prof. Dr. Donghui (Don) Zhu
Prof. Dr. Nan Zhao
Guest Editors

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Keywords

  • nanoparticles
  • nanorobots
  • physical regulation of cells
  • biomaterials
  • blood-brain barrier
  • drug delivery
  • nanocarriers
  • tissue engineering
  • regeneration
  • biomarkers
  • gold nanoparticle
  • smart nanodevice
  • nanoparticle imaging
  • theranostics

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Published Papers (2 papers)

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Review

28 pages, 4252 KiB  
Review
Progress, Opportunities, and Challenges of Magneto-Plasmonic Nanoparticles under Remote Magnetic and Light Stimulation for Brain-Tissue and Cellular Regeneration
by Muzhaozi Yuan, Mackenzie Caitlin Harnett, Tian-Hao Yan, Elias Georgas, Yi-Xian Qin, Hong-Cai Zhou and Ya Wang
Nanomaterials 2022, 12(13), 2242; https://doi.org/10.3390/nano12132242 - 29 Jun 2022
Cited by 6 | Viewed by 3096
Abstract
Finding curable therapies for neurodegenerative disease (ND) is still a worldwide medical and clinical challenge. Recently, investigations have been made into the development of novel therapeutic techniques, and examples include the remote stimulation of nanocarriers to deliver neuroprotective drugs, genes, growth factors, and [...] Read more.
Finding curable therapies for neurodegenerative disease (ND) is still a worldwide medical and clinical challenge. Recently, investigations have been made into the development of novel therapeutic techniques, and examples include the remote stimulation of nanocarriers to deliver neuroprotective drugs, genes, growth factors, and antibodies using a magnetic field and/or low-power lights. Among these potential nanocarriers, magneto-plasmonic nanoparticles possess obvious advantages, such as the functional restoration of ND models, due to their unique nanostructure and physiochemical properties. In this review, we provide an overview of the latest advances in magneto-plasmonic nanoparticles, and the associated therapeutic approaches to repair and restore brain tissues. We have reviewed their potential as smart nanocarriers, including their unique responsivity under remote magnetic and light stimulation for the controlled and sustained drug delivery for reversing neurodegenerations, as well as the utilization of brain organoids in studying the interaction between NPs and neuronal tissue. This review aims to provide a comprehensive summary of the current progress, opportunities, and challenges of using these smart nanocarriers for programmable therapeutics to treat ND, and predict the mechanism and future directions. Full article
(This article belongs to the Special Issue Nanotechnology and Nanomaterials in Biological Systems and Medicine)
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29 pages, 3480 KiB  
Review
Applications of Various Types of Nanomaterials for the Treatment of Neurological Disorders
by Abdul Waris, Asmat Ali, Atta Ullah Khan, Muhammad Asim, Doaa Zamel, Kinza Fatima, Abdur Raziq, Muhammad Ajmal Khan, Nazia Akbar, Abdul Baset and Mohammed A. S. Abourehab
Nanomaterials 2022, 12(13), 2140; https://doi.org/10.3390/nano12132140 - 22 Jun 2022
Cited by 35 | Viewed by 6850
Abstract
Neurological disorders (NDs) are recognized as one of the major health concerns globally. According to the World Health Organization (WHO), neurological disorders are one of the main causes of mortality worldwide. Neurological disorders include Alzheimer’s disease, Parkinson′s disease, Huntington′s disease, Amyotrophic lateral sclerosis, [...] Read more.
Neurological disorders (NDs) are recognized as one of the major health concerns globally. According to the World Health Organization (WHO), neurological disorders are one of the main causes of mortality worldwide. Neurological disorders include Alzheimer’s disease, Parkinson′s disease, Huntington′s disease, Amyotrophic lateral sclerosis, Frontotemporal dementia, Prion disease, Brain tumor, Spinal cord injury, and Stroke. These diseases are considered incurable diseases because no specific therapies are available to cross the blood-brain barrier (BBB) and reach the brain in a significant amount for the pharmacological effect in the brain. There is a need for the development of strategies that can improve the efficacy of drugs and circumvent BBB. One of the promising approaches is the use of different types of nano-scale materials. These nano-based drugs have the ability to increase the therapeutic effect, reduce toxicity, exhibit good stability, targeted delivery, and drug loading capacity. Different types and shapes of nanomaterials have been widely used for the treatment of neurological disorders, including quantum dots, dendrimers, metallic nanoparticles, polymeric nanoparticles, carbon nanotubes, liposomes, and micelles. These nanoparticles have unique characteristics, including sensitivity, selectivity, and the ability to cross the BBB when used in nano-sized particles, and are widely used for imaging studies and treatment of NDs. In this review, we briefly summarized the recent literature on the use of various nanomaterials and their mechanism of action for the treatment of various types of neurological disorders. Full article
(This article belongs to the Special Issue Nanotechnology and Nanomaterials in Biological Systems and Medicine)
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