Special Issue "Multicore Magnetic Nanoparticles for Biomedical Applications"
A special issue of Nanomaterials (ISSN 2079-4991).
Deadline for manuscript submissions: 31 October 2021.
Magnetic nanoparticles, including metallic (iron, cobalt), alloy (iron–platinum, iron–cobalt) or iron oxide (magnetite, maghemite or ferrite phase) exhibit a singular property called superparamagnetism. The nanoscale size of these nanoparticles makes their superparamagnetic properties both size- and shape-dependent. In addition to these two parameters, the presence of magnetic interactions between nanoparticles induce a new magnetic state. This is especially true for multicore magnetic nanoassemblies. Multicore nanoassemblies include magnetic nanoparticles embedded or decorating organic, polymer or biological matrices. In these structures, the number of interacting nanoparticles and the distances between them can lead to two new magnetic orders: superspin glass and super(ferro/ferri)-magnetic state. In the first case, the nanoparticles are in dipolar interactions, which induces a strong spin-frustation. The second case is characterized by nanoparticles in exchange coupling, causing a collective magnetic order. This Special Issue of Nanomaterials, “Multicore Magnetic Nanoparticles for Biomedical Applications”, aims to highlight how interparticle interactions affect the properties of multicore nanoassemblies labeled for biomedical application. The topic covers a wide range of biomedical applications, including but not limited to magnetic fluid hyperthermia, magnetic resonance imaging, on-demand drug delivery or magnetic particle imaging. The format of the expected contributions includes communications, articles or reviews.
Dr. Lenaic Lartigue
Manuscript Submission Information
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- Magnetic multicore nanoparticles
- Superferri–superferromagnetic nanoparticles
- Interparticle magnetic Interaction
- Magnetic resonance imaging (MRI)
- Magnetic fluid hyperthermia (MFH)
- Magnetic particle imaging (MPI)
- On-demand drug delivery systems
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Luminophore and Magnetic Multicore Nanoassemblies for Dual Mode MRI and Fluorescence Imaging
Authors: Lénaïc Lartigue,* Marina Coupeau, Mélanie Lesault
Affiliation: Université de Nantes, CEISAM–UMR CNRS 6230, Nantes, France
Correspondence: [email protected]
Abstract: Nanoassemblies encompass a large variety of systems (organic, crystal, amorphous and porous). The nanometric size enables these systems to interact with biological entities and cellular organelles of similar dimensions (proteins, cells, tumor …). Over the past 20 years, the exploitation of their singular properties as contrast agents has led to the improvement of medical imaging. The use of nanoprobes also allows the combination of several active units within the same nanostructure, paving the way to multi-imaging. Thus, the nano-object provides various additional information which help simplifying the amount of clinical procedures. In this review, we are interested in the combination between fluorescent units and magnetic nanoparticles to perform dual mode magnetic resonance imaging and fluorescent imaging. The effect of magnetic interaction in multicore iron oxide nanoparticles on the MRI contrast agent properties are investigated.
Keyword: Fluorescence imaging, MRI contrast agents, multicore magnetic nanoparticles, supramolecular assemblies, dual-mode imaging
Title: From single-core nanoparticles in ferrofluids to multi-core magnetic nanocomposites
Authors: Theodora Krasia-Christoforou1, V. Socoliuc2, K.D. Knudsen3, Etelka Tombacz4, L. Vekas2, Rodica Turcu5
Affiliation: 1University of Cyprus, Department of Mechanical and Manufacturing Engineering, 75, Kallipoleos Avenue, P.O. Box 20537, 1678, Nicosia, CYPRUS 2Romanian Academy – Timisoara Branch, Center for Fundamental and Advanced Technical Research, Laboratory of Magnetic Fluids, Mihai Viteazul Ave. 24, 300223 Timisoara, Romania 3Institute for Energy Technology (IFE), Physics Departement, 2027 Kjeller, Norway 4University of Szeged, Department of Food Engineering, Faculty of Engineering, Moszkvai krt. 5-7, H-6725 Szeged, Hungary 5National Institute for Research and Development of Isotopic and Molecular Technologies, Department of Physics of Nanostructured Systems, Donat Str. 67-103, 400293, Cluj-Napoca, Romania
Abstract: Iron oxide nanoparticles are the basic components of the most promising magnetoresponsive nanoparticle systems for nanomedicine and biotechnology. Multi-core iron-oxide nanoparticles with high magnetic moment and well-defined size, shape and functional coating, are designed to fulfill the specific requirements of various applications, such as contrast agents, heating mediators, drug targeting or magnetic bio-separation. The review summarizes recent results in manufacturing multi-core magnetic nanoparticle systems, emphasizing the synthesis procedures starting from ferrofluids (with single core MNPs) as primary materials to prepare multicore magnetic particles. The synthesis will follow by presentation of the functionalization and manifold physical-chemical characterization of multicore particles: single- and multicore particle size distribution (TEM, HRTEM), internal structure (SANS, SAXS), zeta potential/surface charge, surface coating, functionalization, morphology (shape, surface area), as well as to DC and AC magnetic properties. The last part of the review is intended to illustrate the efficiency of multicore magnetoresponsive nanosystems in biomedical applications.