Special Issue "Multicore Magnetic Nanoparticles for Biomedical Applications"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Dr. Lenaic Lartigue
E-Mail Website
Guest Editor
CEISAM laboratory - University of NantesNantes, France
Interests: Fluorescence; nanomagnetic; plasma; nano-combination; medical imaging

Special Issue Information

Dear Colleagues,

Magnetic nanoparticles, including metallic (iron, cobalt), alloy (iron–platinum, iron–cobalt) or iron oxide (magnetite, maghemite or ferrite phase) exhibit a singular property called superparamagnetism. The nanoscale size of these nanoparticles makes their superparamagnetic properties both size- and shape-dependent. In addition to these two parameters, the presence of magnetic interactions between nanoparticles induce a new magnetic state. This is especially true for multicore magnetic nanoassemblies. Multicore nanoassemblies include magnetic nanoparticles embedded or decorating organic, polymer or biological matrices. In these structures, the number of interacting nanoparticles and the distances between them can lead to two new magnetic orders: superspin glass and super(ferro/ferri)-magnetic state. In the first case, the nanoparticles are in dipolar interactions, which induces a strong spin-frustation. The second case is characterized by nanoparticles in exchange coupling, causing a collective magnetic order. This Special Issue of Nanomaterials, “Multicore Magnetic Nanoparticles for Biomedical Applications”, aims to highlight how interparticle interactions affect the properties of multicore nanoassemblies labeled for biomedical application. The topic covers a wide range of biomedical applications, including but not limited to magnetic fluid hyperthermia, magnetic resonance imaging, on-demand drug delivery or magnetic particle imaging. The format of the expected contributions includes communications, articles or reviews.

Dr. Lenaic Lartigue
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Magnetic multicore nanoparticles
  • Superferri–superferromagnetic nanoparticles
  • Interparticle magnetic Interaction
  • Magnetic resonance imaging (MRI)
  • Magnetic fluid hyperthermia (MFH)
  • Magnetic particle imaging (MPI)
  • On-demand drug delivery systems

Published Papers (3 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

Article
Reproducibility and Scalability of Magnetic Nanoheater Synthesis
Nanomaterials 2021, 11(8), 2059; https://doi.org/10.3390/nano11082059 - 13 Aug 2021
Viewed by 526
Abstract
The application of magnetic nanoparticles requires large amounts of materials of reproducible quality. This work explores the scaled-up synthesis of multi-core iron oxide nanoparticles through the use of thermal decomposition in organic media and kilograms of reagents. To this end, we check the [...] Read more.
The application of magnetic nanoparticles requires large amounts of materials of reproducible quality. This work explores the scaled-up synthesis of multi-core iron oxide nanoparticles through the use of thermal decomposition in organic media and kilograms of reagents. To this end, we check the effect of extending the high temperature step from minutes to hours. To address the intrinsic variability of the colloidal crystallization nucleation process, the experiments were repeated and analyzed statistically. Due to the simultaneity of the nuclei growth and agglomeration steps, the nanostructure of the samples produced was a combination of single- and multi-core nanoparticles. The main characteristics of the materials obtained, as well as the reaction yields, were analyzed and compared. As a general rule, yield, particle size, and reproducibility increase when the time at high temperature is prolonged. The samples obtained were ranked in terms of the reproducibility of different structural, colloidal, and magnetic features. The capability of the obtained materials to act as nanoheaters in magnetic hyperthermia was assessed, showing a strong dependence on the crystallite size (calculated by X-ray diffraction), reflecting the nanoparticle volume with a coherent magnetization reversal. Full article
(This article belongs to the Special Issue Multicore Magnetic Nanoparticles for Biomedical Applications)
Show Figures

Graphical abstract

Review

Jump to: Research

Review
From Single-Core Nanoparticles in Ferrofluids to Multi-Core Magnetic Nanocomposites: Assembly Strategies, Structure, and Magnetic Behavior
Nanomaterials 2020, 10(11), 2178; https://doi.org/10.3390/nano10112178 - 31 Oct 2020
Cited by 8 | Viewed by 1348
Abstract
Iron oxide nanoparticles are the basic components of the most promising magnetoresponsive nanoparticle systems for medical (diagnosis and therapy) and bio-related applications. Multi-core iron oxide nanoparticles with a high magnetic moment and well-defined size, shape, and functional coating are designed to fulfill the [...] Read more.
Iron oxide nanoparticles are the basic components of the most promising magnetoresponsive nanoparticle systems for medical (diagnosis and therapy) and bio-related applications. Multi-core iron oxide nanoparticles with a high magnetic moment and well-defined size, shape, and functional coating are designed to fulfill the specific requirements of various biomedical applications, such as contrast agents, heating mediators, drug targeting, or magnetic bioseparation. This review article summarizes recent results in manufacturing multi-core magnetic nanoparticle (MNP) systems emphasizing the synthesis procedures, starting from ferrofluids (with single-core MNPs) as primary materials in various assembly methods to obtain multi-core magnetic particles. The synthesis and functionalization will be followed by the results of advanced physicochemical, structural, and magnetic characterization of multi-core particles, as well as single- and multi-core particle size distribution, morphology, internal structure, agglomerate formation processes, and constant and variable field magnetic properties. The review provides a comprehensive insight into the controlled synthesis and advanced structural and magnetic characterization of multi-core magnetic composites envisaged for nanomedicine and biotechnology. Full article
(This article belongs to the Special Issue Multicore Magnetic Nanoparticles for Biomedical Applications)
Show Figures

Figure 1

Review
Luminophore and Magnetic Multicore Nanoassemblies for Dual-Mode MRI and Fluorescence Imaging
Nanomaterials 2020, 10(1), 28; https://doi.org/10.3390/nano10010028 - 20 Dec 2019
Cited by 10 | Viewed by 1803
Abstract
Nanoassemblies encompass a large variety of systems (organic, crystalline, amorphous and porous). The nanometric size enables these systems to interact with biological entities and cellular organelles of similar dimensions (proteins, cells, …). Over the past 20 years, the exploitation of their singular properties [...] Read more.
Nanoassemblies encompass a large variety of systems (organic, crystalline, amorphous and porous). The nanometric size enables these systems to interact with biological entities and cellular organelles of similar dimensions (proteins, cells, …). Over the past 20 years, the exploitation of their singular properties as contrast agents has led to the improvement of medical imaging. The use of nanoprobes also allows the combination of several active units within the same nanostructure, paving the way to multi-imaging. Thus, the nano-object provides various additional information which helps simplify the number of clinical procedures required. In this review, we are interested in the combination between fluorescent units and magnetic nanoparticles to perform dual-mode magnetic resonance imaging (MRI) and fluorescent imaging. The effect of magnetic interaction in multicore iron oxide nanoparticles on the MRI contrast agent properties is highlighted. Full article
(This article belongs to the Special Issue Multicore Magnetic Nanoparticles for Biomedical Applications)
Show Figures

Figure 1

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Luminophore and Magnetic Multicore Nanoassemblies for Dual Mode MRI and Fluorescence Imaging
Authors: Lénaïc Lartigue,* Marina Coupeau, Mélanie Lesault
Affiliation: Université de Nantes, CEISAM–UMR CNRS 6230, Nantes, France
Correspondence: [email protected]
Abstract: Nanoassemblies encompass a large variety of systems (organic, crystal, amorphous and porous). The nanometric size enables these systems to interact with biological entities and cellular organelles of similar dimensions (proteins, cells, tumor …). Over the past 20 years, the exploitation of their singular properties as contrast agents has led to the improvement of medical imaging. The use of nanoprobes also allows the combination of several active units within the same nanostructure, paving the way to multi-imaging. Thus, the nano-object provides various additional information which help simplifying the amount of clinical procedures. In this review, we are interested in the combination between fluorescent units and magnetic nanoparticles to perform dual mode magnetic resonance imaging and fluorescent imaging. The effect of magnetic interaction in multicore iron oxide nanoparticles on the MRI contrast agent properties are investigated.
Keyword: Fluorescence imaging, MRI contrast agents, multicore magnetic nanoparticles, supramolecular assemblies, dual-mode imaging

Title: From single-core nanoparticles in ferrofluids to multi-core magnetic nanocomposites
Authors: Theodora Krasia-Christoforou1, V. Socoliuc2, K.D. Knudsen3, Etelka Tombacz4, L. Vekas2, Rodica Turcu5
Affiliation: 1University of Cyprus, Department of Mechanical and Manufacturing Engineering, 75, Kallipoleos Avenue, P.O. Box 20537, 1678, Nicosia, CYPRUS 2Romanian Academy – Timisoara Branch, Center for Fundamental and Advanced Technical Research, Laboratory of Magnetic Fluids, Mihai Viteazul Ave. 24, 300223 Timisoara, Romania 3Institute for Energy Technology (IFE), Physics Departement, 2027 Kjeller, Norway 4University of Szeged, Department of Food Engineering, Faculty of Engineering, Moszkvai krt. 5-7, H-6725 Szeged, Hungary 5National Institute for Research and Development of Isotopic and Molecular Technologies, Department of Physics of Nanostructured Systems, Donat Str. 67-103, 400293, Cluj-Napoca, Romania
Abstract: Iron oxide nanoparticles are the basic components of the most promising magnetoresponsive nanoparticle systems for nanomedicine and biotechnology. Multi-core iron-oxide nanoparticles with high magnetic moment and well-defined size, shape and functional coating, are designed to fulfill the specific requirements of various applications, such as contrast agents, heating mediators, drug targeting or magnetic bio-separation. The review summarizes recent results in manufacturing multi-core magnetic nanoparticle systems, emphasizing the synthesis procedures starting from ferrofluids (with single core MNPs) as primary materials to prepare multicore magnetic particles. The synthesis will follow by presentation of the functionalization and manifold physical-chemical characterization of multicore particles: single- and multicore particle size distribution (TEM, HRTEM), internal structure (SANS, SAXS), zeta potential/surface charge, surface coating, functionalization, morphology (shape, surface area), as well as to DC and AC magnetic properties. The last part of the review is intended to illustrate the efficiency of multicore magnetoresponsive nanosystems in biomedical applications.

Back to TopTop