Special Issue "Graphene-based Materials for Cancer Therapy"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 25 September 2019

Special Issue Editors

Guest Editor
Prof. Daniela Iannazzo

Department of Engineering, University of Messina, Contrada Di Dio, I-98166 Messina, Italy
Website | E-Mail
Interests: Organic Synthesis; Advanced synthetic methodologies for the organic functionalization of nanomaterials for applications in drug delivery, biosensors, tissue engineering and in environmental field.
Guest Editor
Prof. Alessandro Pistone

Department of Engineering, University of Messina, Contrada Di Dio, I-98166 Messina, Italy
Website | E-Mail
Interests: Nanomaterials; Drug Delivery Systems; Tissue Engineering; Biomaterials

Special Issue Information

Dear Colleagues,

Graphene-based nanomaterials such as fullerenes, carbon nanotubes graphene oxide, and graphene quantum dots have shown great potential in revolutionizing the future of nanomedicine and biotechnology. Their outstanding physical and chemical properties and the presence of more reactive groups on the graphene surface, which allow the multimodal conjugation with different functional groups and biologically active molecules, make them ideal candidates for cancer diagnosis and treatment. These nanomaterials have been conjugated with drugs and also labeled with tumor-targeting ligands, which are able to specifically recognize cancer receptors exposed on cancer cells, thus allowing a more efficient targeted delivery of anticancer agents while minimizing their distribution in healthy tissues. Graphene-based materials have been also investigated for the development of new imaging agents for the in vitro and in vivo diagnosis of several types of cancer as well as for the development of biosensors for the identification of specific cancer bio-markers. “Graphene-based materials for cancer therapy” aims at collecting full papers communications and reviews that prominently demonstrate the continuous efforts in developing advanced, graphene-based nanomaterials for cancer treatment and diagnosis. This Special Issue aims to cover a broad range of subjects, from nanomaterials synthesis to the design and development of nanostructures to be used as drug delivery systems, biosensors, and imaging agents for cancer treatment.

Prof. Daniela Iannazzo
Prof. Alessandro Pistone
Guest Editors

Manuscript Submission Information

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Keywords

  • graphene-based materials
  • anticancer therapy
  • drug delivery systems
  • imaging agents
  • biosensors

Published Papers (1 paper)

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Research

Open AccessArticle A Smart Nanovector for Cancer Targeted Drug Delivery Based on Graphene Quantum Dots
Nanomaterials 2019, 9(2), 282; https://doi.org/10.3390/nano9020282
Received: 9 January 2019 / Revised: 8 February 2019 / Accepted: 10 February 2019 / Published: 18 February 2019
PDF Full-text (3851 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Graphene quantum dots (GQD), the new generation members of graphene-family, have shown promising applications in anticancer therapy. In this study, we report the synthesis of a fluorescent and biocompatible nanovector, based on GQD, for the targeted delivery of an anticancer drug with benzofuran [...] Read more.
Graphene quantum dots (GQD), the new generation members of graphene-family, have shown promising applications in anticancer therapy. In this study, we report the synthesis of a fluorescent and biocompatible nanovector, based on GQD, for the targeted delivery of an anticancer drug with benzofuran structure (BFG) and bearing the targeting ligand riboflavin (RF, vitamin B2). The highly water-dispersible nanoparticles, synthesized from multi-walled carbon nanotubes (MWCNT) by prolonged acidic treatment, were linked covalently to the drug by means of a cleavable PEG linker while the targeting ligand RF was conjugated to the GQD by π–π interaction using a pyrene linker. The cytotoxic effect of the synthesized drug delivery system (DDS) [email protected] was tested on three cancer cell lines and this effect was compared with that exerted by the same nanovector lacking the RF ligand (GQD-PEG-BFG) or the anticancer drug ([email protected]). The results of biological tests underlined the low cytotoxicity of the GQD sample and the cytotoxic activity of the DDS against the investigated cancer cell lines with a higher or similar potency to that exerted by the BFG alone, thus opening new possibilities for the use of this drug or other anticancer agents endowed of cytotoxicity and serious side effects. Full article
(This article belongs to the Special Issue Graphene-based Materials for Cancer Therapy)
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