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Special Issue "Anti-Cancer, Biochemical and Immunological Activity of Nanoparticles "
Deadline for manuscript submissions: 15 February 2020.
It is an exciting time for nanomaterials. Their biomedical applications are numerous, and as their drug, nucleic acid, and protein complexes and conjugates begin translating from cell culture to animal studies and into the clinic, this gives us new hope in the fight against many cancers and possibly diseases with bacterial or viral pathogenesis. Research is now very active on what the anticancer, biochemical, and immunological mechanisms are for nanoparticles. For example, some groups have reported that certain nanoparticle compositions can inhibit enzymes and reduce their biochemical activity, and this may have potential applications for new cancer therapeutic or antibacterial strategies. Others utilize various synthetic chemistries to produce nanoparticle core-shell structures and composites that may have tunable physico-chemical properties and biological activities. For cancer nanotechnology, an exciting area is combining nanoparticles with targeting or therapeutic antibodies to better direct them to the tumor and/or elicit a desirable biochemical and immunological effect. This Special Issue seeks contributers from all branches of applied nanotechnology with a focus on anticancer, biochemical, and immunological activities as potential therapeutic or diagnostic agents.
Dr. Robert K. DeLong
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Intracellular Trafficking of Gold Nanostars for Plasmonic Photothermal Therapy in Uvea Cancer Cells
Authors: Rubén Ahijado-Guzmán; Natalia Sánchez-Arribas; María Martínez-Negro; Guillermo Gonzalez-Rubio; María Santiago-Varela; María Pardo; Antonio Piñeiro; Iván López-Montero; Elena Junquera; Andrés Guerrero-Martínez
Abstract: Nowadays the chase for efficient plasmonic photothermal therapies (PPTT) by using non-harmful pulse laser irradiation at the near-infrared (NIR) is a fundamental goal for medical cancer research. Therefore, the development of novel plasmonic gold nanostructures with the aim of reducing the applied laser power density is still an ongoing challenge. However, the cells, due to their unsettled capacity for uptake, retain, release and re-uptake gold nanoparticles (GNP) offer an enormous versatility for research depending on the cell line and GNP size, shape and surface modification. Here, we have determined the photothermal effect on uvea cancer cells by using gold nanostars (GNS) and femtosecond pulse lasers through different approaches. First, we have investigated the photothermal effect with the dilution of GNS generated by the cell division at two different GNS concentrations. The use of highly efficient GNS combined with low pulse laser irradiation at the NIR, has led us to obtain highly PPTT efficiency after 4 cell division cycles with an initial GNS concentration of 8 pM. Subsequently, we have determined the photothermal effect with the cell division as a result of the mixing of GNS-loaded and non-loaded cells. By mixing GNS-loaded and non-loaded cells with an effective GNS concentration of 4 pM, we have observed a trafficking of GNS between the loaded and non-loaded cells obtaining an effective PPTT after 4 division cycles and the same low irradiance conditions. Our study reveals the ability of the cells to release and re-uptake GNS and keep their plasmonic photothermal properties across the cell division cycles, and after the re-uptaking process. These approaches shape a key study that could potentially be used as alternative co therapy to spread nanoplasmonic active gold nanostructures throughout affected tissues and thus, expand the effectiveness of classic PPTT.