From Measurements to Predictive Models: Recent Advancements in Nanosafety Research

Dear Colleagues,

Understanding the interactions of engineered nanomaterials with biological systems and the environment is becoming increasingly important due to the rapid growth of the nano-industry, such as biomedical applications of nanomaterials for therapeutics and diagnosis. Conventional measurement methods for nanomaterials’ physicochemical properties and in vitro toxicity assessment have been widely applied, and their outcomes have been used for the development of predictive models of nanotoxicity. However, the limitations of these conventional methods, such as interference from cell–nanoparticle interactions and an inability to probe the complex heterogeneities of both nanoparticles and biological systems, prevent the development of better-performing predictive models of nanotoxicity and underlying mechanisms. In this Special Issue, we invite reviews, research articles and communications on recent advancements in nanosafety research, particularly on novel measurement methods for the physicochemical and biological properties of nanomaterials as well as advanced models developed with novel algorithms and/or high-dimensional datasets collected with high-content and high-throughput measurement methods. The potential topics for this Special Issue include but are not limited to:

1. Advanced characterization methods for nanomaterials and nanoproducts (e.g., nanoparticle-tracking analysis, single-particle ICP-MS etc.);
2. Novel assessment methods with single-cell resolution for probing the heterogeneities of nanoparticles interacting with complex biological systems (e.g., mass cytometry, single-cell RNAseq etc.);
3. Advanced models developed with novel algorithms and/or high-dimensional datasets collected with high-content and high-throughput assay methods;
4. Physicochemical characterization, toxicity assessment and predictive-model development for novel nanomaterials (e.g., upconversion nanoparticles (UCNPs), 2D nanomaterials etc.).

Prof. Dr. Tae-Hyun Yoon
Prof. Dr. Eugenia Valsami-Jones
Prof. Dr. Dario Greco
Dr. Antreas Afantitis
Dr. Haribalan Perumalsamy
Dr. Zayakhuu Gerelkhuu
Guest Editors

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