Green Nanoparticles for Topical Administration of Drugs
A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".
Deadline for manuscript submissions: 13 June 2025 | Viewed by 1973
Special Issue Editors
Interests: nanotechnology; lipid-based drug delivery systems; natural antioxidants; transdermal delivery systems; semisolid formulations
Special Issues, Collections and Topics in MDPI journals
Interests: nanomedicine; regenerative medicine; cell imaging; ageing; muscle atrophy/dystrophy; antioxidant processes
Special Issues, Collections and Topics in MDPI journals
Interests: protein; Small Angle X-ray and Neutron Scattering (SAXS +SANS); folding; amyloid; Intrinsic Disordered Proteins (IDP); scattering
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The topical administration of drugs represents a route to treat pathologies affecting the skin (e.g. inflammations, infections, melanoma, and psoriasis) or mucosae (e.g. viral infections, and candidiasis). Conventional semi-solid forms, such as creams and gels, allow achieving only local effects since the stratum corneum barrier properties hamper the absorption of many drugs. Conversely, nanoparticle-based topical formulations can provide sustained drug release, promoting drug permeation into deeper layers of the skin or through the mucosae. Indeed, nanoparticles offer broad potential as drug delivery systems, being able to solubilize both hydrophobic and hydrophilic drugs in a physiological environment suitable to prevent compound degradation and to control their release. Nanoparticulate drug delivery systems include vesicular nanocarriers (e.g. liposomes and ethosomes), as well as solid nanoparticles, dendrimers, and quantum dots. Recently, research efforts have been devoted to the development of green approaches to produce nanoparticles by sustainable methods, avoiding the use of toxic materials and organic solvents, and preventing expensive processes, as well as waste product formation. In particular, the use of plant extract is greatly increasing in the nanotechnology field. The physical–chemical characterization of nanoparticles—particularly their size distribution and external and internal architecture—is needed to understand the effect of size and morphology on nanoparticle uptake through the skin and mucosae.
This Special Issue is open for submissions of the most recent findings on nanoparticulate drug delivery systems, based on sustainable approaches and natural matrixes, for dermatological and mucosal applications.
Dr. Elisabetta Esposito
Dr. Manuela Malatesta
Dr. Maria Grazia Ortore
Guest Editors
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Keywords
- green nanoparticles
- liposomes
- ethosomes
- skin
- mucosae
- transdermal delivery
- sustainability
- natural polymers
- lipids
- phospholipids
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