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Nanomaterials
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Multifunctional Nanomaterials for Biomedical and Environmental Applications
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Multifunctional Nanomaterials for Biomedical and Environmental Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 9862

Special Issue Editor

Dr. Miryana Hémadi

E-Mail Website
Guest Editor
ITODYS Laboratory, Chemistry Department, Université de Paris, 75013 Paris, France
Interests: synthesis and elaboration of multifunctional nanomaterials; magnetic and optical nanoparticles; surface modification and functionalization; interaction with biomolecules; thermal therapies (photothermia and magnetic hyperthermia); nanomedecine; heavy-metal and polluant extraction; water decontamination; magnetic harvesting; biodegradation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the last few decades, the synthesis and elaboration of multifunctional nanomaterials have attracted many researchers in different fields, in particular environmental science and nanomedicine. In this Special Issue, we will be interested in several classes of materials (magnetic, carbonaceous, and hybrid nanomaterials) whose excellent physical and chemical properties and low toxicity mean that they can be exploited for a wide variety of applications. The functionalization of these nanomaterials increases their efficacy and specificity. This can be easily achieved by binding proteins or other biomolecules to their surface in order to enhance their potential in nanomedicine, for example, for targeting, drug delivery, and controlled release. Grafting chelators and other small molecules onto these materials can provide decisive advantage for their use in the decontamination of wastewater from heavy metals or organic polluants.

Your participation in the present Special Issue on "Multifunctional Nanomaterials for Biomedical and Environmental Applications" will provide the readers of Nanomaterials with an overview of the latest research in these fields. This Special Issue will cover the synthesis and functionalization of different nanomaterials, as well as their characterization and application in the fields of nanomedicine (for bioimaging, thermal therapy, drug delivery, targeting, etc.) and environmental science (detection, heavy-metal extraction, magnetic harvesting, etc.).

Dr. Miryana HEMADI
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Magnetic nanoparticles
  • Carbon nanomaterials
  • Surface modification
  • Functionalization
  • Thermal therapies
  • Bioimaging
  • Heavy-metal extraction
  • Polluant degradation
  • Biomedical applications
  • Environmental applications

Published Papers (4 papers)

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Research

12 pages, 2391 KiB  
Article
Effect of Serum Albumin on Porphyrin-Quantum Dot Complex Formation, Characteristics and Spectroscopic Analysis
by André L. S. Pavanelli, Leandro N. C. Máximo, Roberto S. da Silva and Iouri E. Borissevitch
Nanomaterials 2021, 11(7), 1674; https://doi.org/10.3390/nano11071674 - 25 Jun 2021
Cited by 2 | Viewed by 1760
Abstract
The effect of bovine serum albumin (BSA) upon interaction between CdTe QD functionalized by 3-Mercaptopropionic Acid (CdTe-3-MPA QD) and two water soluble porphyrins: positively charged meso-tetra methyl pyridyl porphyrin (TMPyP) and negatively charged meso-tetrakis(p-sulfonato-phenyl) porphyrin (TPPS4), was studied in [...] Read more.
The effect of bovine serum albumin (BSA) upon interaction between CdTe QD functionalized by 3-Mercaptopropionic Acid (CdTe-3-MPA QD) and two water soluble porphyrins: positively charged meso-tetra methyl pyridyl porphyrin (TMPyP) and negatively charged meso-tetrakis(p-sulfonato-phenyl) porphyrin (TPPS4), was studied in function of pH using the steady-state and time resolved optical absorption and fluorescence spectroscopies. It was shown that, depending on the charge state of the components, interaction with albumin could either prevent the formation of the QD…PPh complex, form a mixed QD…PPh…BSA complex or not affect PPh complexation with QD at all. The obtained results may be of interest for application in photomedicine. Full article
(This article belongs to the Special Issue Multifunctional Nanomaterials for Biomedical and Environmental Applications)
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11 pages, 3145 KiB  
Article
Preparation of Fe3O4-Ag Nanocomposites with Silver Petals for SERS Application
by Thi Thuy Nguyen, Fayna Mammeri, Souad Ammar, Thi Bich Ngoc Nguyen, Trong Nghia Nguyen, Thi Ha Lien Nghiem, Nguyen Thi Thuy and Thi Anh Ho
Nanomaterials 2021, 11(5), 1288; https://doi.org/10.3390/nano11051288 - 13 May 2021
Cited by 6 | Viewed by 2305
Abstract
The formation of silver nanopetal-Fe3O4 poly-nanocrystals assemblies and the use of the resulting hetero-nanostructures as active substrates for Surface Enhanced Raman Spectroscopy (SERS) application are here reported. In practice, about 180 nm sized polyol-made Fe3O4 spheres, constituted [...] Read more.
The formation of silver nanopetal-Fe3O4 poly-nanocrystals assemblies and the use of the resulting hetero-nanostructures as active substrates for Surface Enhanced Raman Spectroscopy (SERS) application are here reported. In practice, about 180 nm sized polyol-made Fe3O4 spheres, constituted by 10 nm sized crystals, were functionalized by (3-aminopropyl)triethoxysilane (APTES) to become positively charged, which can then electrostatically interact with negatively charged silver seeds. Silver petals were formed by seed-mediated growth in presence of Ag+ cations and self-assembly, using L-ascorbic acid (L-AA) and polyvinyl pyrrolidone (PVP) as mid-reducing and stabilizing agents, respectively. The resulting plasmonic structure provides a rough surface with plenty of hot spots able to locally enhance significantly any applied electrical field. Additionally, they exhibited a high enough saturation magnetization with Ms = 9.7 emu g−1 to be reversibly collected by an external magnetic field, which shortened the detection time. The plasmonic property makes the engineered Fe3O4-Ag architectures particularly valuable for magnetically assisted ultra-sensitive SERS sensing. This was unambiguously established through the successful detection, in water, of traces, (down to 10−10 M) of Rhodamine 6G (R6G), at room temperature. Full article
(This article belongs to the Special Issue Multifunctional Nanomaterials for Biomedical and Environmental Applications)
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17 pages, 2377 KiB  
Article
Grafting TRAIL through Either Amino or Carboxylic Groups onto Maghemite Nanoparticles: Influence on Pro-Apoptotic Efficiency
by Hanene Belkahla, Andrei Alexandru Constantinescu, Tijani Gharbi, Florent Barbault, Alexandre Chevillot-Biraud, Philippe Decorse, Olivier Micheau, Miryana Hémadi and Souad Ammar
Nanomaterials 2021, 11(2), 502; https://doi.org/10.3390/nano11020502 - 17 Feb 2021
Cited by 4 | Viewed by 2071
Abstract
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF cytokine superfamily. TRAIL is able to induce apoptosis through engagement of its death receptors DR4 and DR5 in a wide variety of tumor cells while sparing vital normal cells. This [...] Read more.
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF cytokine superfamily. TRAIL is able to induce apoptosis through engagement of its death receptors DR4 and DR5 in a wide variety of tumor cells while sparing vital normal cells. This makes it a promising agent for cancer therapy. Here, we present two different ways of covalently grafting TRAIL onto maghemite nanoparticles (NPs): (a) by using carboxylic acid groups of the protein to graft it onto maghemite NPs previously functionalized with amino groups, and (b) by using the amino functions of the protein to graft it onto NPs functionalized with carboxylic acid groups. The two resulting nanovectors, NH-TRAIL@NPs-CO and CO-TRAIL@NPs-NH, were thoroughly characterized. Biological studies performed on human breast and lung carcinoma cells (MDA-MB-231 and H1703 cell lines) established these nanovectors are potential agents for cancer therapy. The pro-apoptotic effect is somewhat greater for CO-TRAIL@NPs-NH than NH-TRAIL@NPs-CO, as evidenced by viability studies and apoptosis analysis. A computational study indicated that regardless of whether TRAIL is attached to NPs through an acid or an amino group, DR4 recognition is not affected in either case. Full article
(This article belongs to the Special Issue Multifunctional Nanomaterials for Biomedical and Environmental Applications)
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13 pages, 3773 KiB  
Article
Preconcentration and Detection of Gefitinib Anti-Cancer Drug Traces from Water and Human Plasma Samples by Means of Magnetic Nanoparticles
by Hadeer Borg, Dániel Zámbó, Heba Elmansi, Heba M. Hashem, Jenny Jehan Nasr, Mohammed I. Walash, Nadja C. Bigall and Fathalla Belal
Nanomaterials 2020, 10(6), 1196; https://doi.org/10.3390/nano10061196 - 19 Jun 2020
Cited by 14 | Viewed by 2845
Abstract
Along of widespread application of anti-cancer drug Gefitinib (GEF), it appears in human body fluids as well as clinical wastewater. Consequently, a reliable and easy-to-adapt detection technique is of essential importance to quantify the drug in different media. The extraction and quantitative detection [...] Read more.
Along of widespread application of anti-cancer drug Gefitinib (GEF), it appears in human body fluids as well as clinical wastewater. Consequently, a reliable and easy-to-adapt detection technique is of essential importance to quantify the drug in different media. The extraction and quantitative detection of anti-cancer drug Gefinitib (GEF) is demonstrated based on a straightforward and efficient magnetic nanoparticle-assisted preconcentration route from water and human plasma samples. Iron oxide magnetic nanoparticles (Fe3O4) have been prepared with an average particle size of 15 nm and utilized as extractible adsorbents for the magnetic solid-phase extraction (MSPE) of GEF in aqueous media. The method is based on MSPE and preconcentration of GEF followed by High-Performance Liquid Chromatography-Ultraviolet Detection (HPLC-UV). The yield of GEF extraction under the optimum MSPE conditions were 94% and 87% for water and plasma samples, respectively. The chromatographic separation was carried out isocratically at 25 °C on a Phenomenex C8 reversed phase column (150 mm × 4.6 mm, with 5 µm particle size). The proposed method was linear over concentration ranges of 15.0–300.0 and 80.0–600.0 ng/mL for water and plasma samples with limits of detection of 4.6 and 25.0 ng/mL in a respective order. Relative standard deviations (%RSD) for intra-day and inter-day were 0.75 and 0.94 for water samples and 1.26 and 1.70 for plasma samples, respectively. Using the magnetic nanoparticles (MNPs) as loaded drug-extractors made the detection of the anti-cancer drug environmentally friendly and simple and has great potential to be used for different drug-containing systems. Full article
(This article belongs to the Special Issue Multifunctional Nanomaterials for Biomedical and Environmental Applications)
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