Special Issue "Nano-Scale Gene Delivery Systems"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: closed (31 May 2020).

Special Issue Editor

Dr. Magali Gary-Bobo
Website
Guest Editor
Institut des Biomolécules Max Mousseron, UMR 5247 CNRS, Montpellier, cedex 05, France
Interests: biological efficiency of nanotools for cancer targeting, therapy and imaging; proof of concept in vitro and in vivo of theranostic potential of photoactivable nanoparticles under one or two-photon excitation for photodynamic therapy, gene or drug delivery, and imaging

Special Issue Information

Dear Colleagues,

Currently, two big challenges in medicine concern (i) the development of highly efficient and biocompatible nanomaterials and (ii) the use of gene therapy. The coupling of these two fields could lead to an unprecedented technological advance and a therapeutic strategy of rupture, thanks to the development of furtive and targeted nanocargos for gene delivery.

In this Special Issue, we are especially interested in works that describe nanomaterials or polymers that are able to capture nuclei acids and deliver them to the targeted tissue. This delivery could be passive or dependent on an external stimulus. This Special Issue invites manuscripts that provide novel scientific findings on the genetic material delivery of nanomaterials.

Dr. Magali Gary-Bobo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • polymers
  • nucleic acids
  • complexation
  • release
  • cell targeting

Published Papers (1 paper)

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Open AccessReview
Nanomedicines to Deliver mRNA: State of the Art and Future Perspectives
Nanomaterials 2020, 10(2), 364; https://doi.org/10.3390/nano10020364 - 20 Feb 2020
Abstract
The use of messenger RNA (mRNA) in gene therapy is increasing in recent years, due to its unique features compared to plasmid DNA: Transient expression, no need to enter into the nucleus and no risk of insertional mutagenesis. Nevertheless, the clinical application of [...] Read more.
The use of messenger RNA (mRNA) in gene therapy is increasing in recent years, due to its unique features compared to plasmid DNA: Transient expression, no need to enter into the nucleus and no risk of insertional mutagenesis. Nevertheless, the clinical application of mRNA as a therapeutic tool is limited by its instability and ability to activate immune responses; hence, mRNA chemical modifications together with the design of suitable vehicles result essential. This manuscript includes a revision of the strategies employed to enhance in vitro transcribed (IVT) mRNA functionality and efficacy, including the optimization of its stability and translational efficiency, as well as the regulation of its immunostimulatory properties. An overview of the nanosystems designed to protect the mRNA and to overcome the intra and extracellular barriers for successful delivery is also included. Finally, the present and future applications of mRNA nanomedicines for immunization against infectious diseases and cancer, protein replacement, gene editing, and regenerative medicine are highlighted. Full article
(This article belongs to the Special Issue Nano-Scale Gene Delivery Systems)
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