Special Issue "Application of Carbon Nanomaterials in Biological Detection"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 20 December 2020.

Special Issue Editors

Prof. Luís Moreira Gonçalves
Website
Guest Editor
Universidade de São Paulo, São Paulo - SP, Brazil
Interests: Analytical Chemistry Biosensors Food Quality; Medicine Medical Diagnostic
Dr. Maria Isabel Pividori Gurgo
Website
Guest Editor
Universitat Autònoma de Barcelona, Barcelona, Spain
Interests: bioanalytical chemistry and biosensing, design of electrochemical biosensing devices and emerging rapid test appropriate at community and primary-care level for clinical diagnosis and food safety in low resource settings

Special Issue Information

Dear Colleagues,

Analytical chemistry is ubiquitous in biological sciences. The detection of biological molecules is of utmost importance in many crucial fields. Many strategies are applied by creative and enthusiast scientists. In this issue, we aim to show some of the possibilities making use of all different types of carbon nanomaterials. Innovative methodologies can be faster, more sensitive, more portable, cheaper or possess many other advantages according to analysts’ wishes.

I hope you can participate in this issue with an exciting submission

Prof. Luís Moreira Gonçalves
Prof. Maria Isabel Pividori Gurgo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • analytical chemistry
  • bioanalysis
  • biosensing
  • carbon
  • electroanalysis
  • sensing

Published Papers (1 paper)

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Research

Open AccessArticle
Carbon Dots for Intracellular pH Sensing with Fluorescence Lifetime Imaging Microscopy
Nanomaterials 2020, 10(4), 604; https://doi.org/10.3390/nano10040604 - 25 Mar 2020
Abstract
The monitoring of intracellular pH is of great importance for understanding intracellular trafficking and functions. It has various limitations for biosensing based on the fluorescence intensity or spectra study. In this research, pH-sensitive carbon dots (CDs) were employed for intracellular pH sensing with [...] Read more.
The monitoring of intracellular pH is of great importance for understanding intracellular trafficking and functions. It has various limitations for biosensing based on the fluorescence intensity or spectra study. In this research, pH-sensitive carbon dots (CDs) were employed for intracellular pH sensing with fluorescence lifetime imaging microscopy (FLIM) for the first time. FLIM is a highly sensitive method that is used to detect a microenvironment and it can overcome the limitations of biosensing methods based on fluorescence intensity. The different groups on the CDs surfaces changing with pH environments led to different fluorescence lifetime values. The CDs aqueous solution had a gradual change from 1.6 ns to 3.7 ns in the fluorescence lifetime with a pH range of 2.6–8.6. Similar fluorescence lifetime changes were found in pH buffer-treated living cells. The detection of lysosomes, cytoplasm, and nuclei in living cells was achieved by measuring the fluorescence lifetime of CDs. In particular, a phasor FLIM analysis was used to improve the pH imaging. Moreover, the effects of the coenzymes, amino acids, and proteins on the fluorescence lifetime of CDs were examined in order to mimic the complex microenvironment inside the cells. Full article
(This article belongs to the Special Issue Application of Carbon Nanomaterials in Biological Detection)
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