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Nanomaterials
Special Issues
Toxicity Evaluation of Nanoparticles: 2nd Edition
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Toxicity Evaluation of Nanoparticles: 2nd Edition

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Environmental Nanoscience and Nanotechnology".

Deadline for manuscript submissions: closed (20 December 2024) | Viewed by 2363

Special Issue Editors

Dr. Rongrong Liu

E-Mail Website
Guest Editor
Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou 510006, China
Interests: nanomaterials; nanotoxicity; fluorescence imaging; environmental microbiology; cell toxicology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Bing Yan

E-Mail Website
Guest Editor
Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Institute of Environmental Research at Greater Bay, Ministry of Education, Guangzhou University, Guangzhou 510006, China
Interests: nanomedicine; nanotoxicology; environmental safety; environmental toxicology; theranostics; imaging; nanoparticle library; nanoparticle modification; surface modification; chemical biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The increasing production and application of nanomaterials causes them to release into the environment, with adverse impacts on ecosystems and human health. Such toxicities must be reliably assessed, the mechanisms must be elucidated, and the risk should be predicted. Therefore, it is essential to develop powerful methods to evaluate nanotoxicity, such as in vitro methods (e.g., cell-based or cell-free testing), animals tests (e.g., zebra fish), and computational modeling. Given this background, this Special Issue will assemble high-quality original research and review papers, highlighting nanotoxicity investigations using various biological models and in-depth mechanism investigations. This Special Issue will also focus on the application of advanced machine learning, deep learning algorithms in nanotoxicity modeling and prediction, and molecular simulation to elucidate the mechanisms of emerging nanomaterials.

Dr. Rongrong Liu
Prof. Dr. Bing Yan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • nanomedicine
  • nanotoxicity
  • nanoparticle modification
  • mechanistic toxicity
  • environmental pollution
  • environmental toxicology
  • nano chemistry
  • cell toxicology
  • molecular toxicology
  • nano functionalization

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Published Papers (2 papers)

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23 pages, 2478 KiB  
Article
Evaluating Toxic Interactions of Polystyrene Microplastics with Hazardous and Noxious Substances Using the Early Life Stages of the Marine Bivalve Crassostrea gigas
by Hoon Choi, Un-Ki Hwang, Moonjin Lee, Youn-Jung Kim and Taejun Han
Nanomaterials 2025, 15(5), 349; https://doi.org/10.3390/nano15050349 - 24 Feb 2025
Viewed by 604
Abstract
Plastics pose a significant threat to marine ecosystems, owing to their slow biodegradability. Microplastics (MPs), in particular, affect marine life and maricultural organisms and can enter the food chain via ingestion by marine organisms, leading to bioaccumulation in predators, including humans. This study [...] Read more.
Plastics pose a significant threat to marine ecosystems, owing to their slow biodegradability. Microplastics (MPs), in particular, affect marine life and maricultural organisms and can enter the food chain via ingestion by marine organisms, leading to bioaccumulation in predators, including humans. This study assessed the toxic interactions between polystyrene microplastic particles (PSMPs) and cadmium (Cd) and phenanthrene (Phe) using marine bivalves. While PSMPs were non-toxic to Pacific oysters (Crassostrea gigas), the toxicity of Cd and Phe was concentration-dependent. In most conditions, PSMPs reduced the toxicity of Cd and Phe, but in simultaneous exposure, they acted as Cd messengers, altering the toxicity during the adult stage. This study confirms that PSMPs can interact with coastal environmental pollutants, thereby accelerating biotoxicity and posing a significant threat to marine wildlife, mariculture, and human health. It also highlights the need to assess MP toxicity in coastal environments and their interactions with pollutants. Full article
(This article belongs to the Special Issue Toxicity Evaluation of Nanoparticles: 2nd Edition)
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13 pages, 2634 KiB  
Article
Effects of Multiple Stressors, Pristine or Sulfidized Silver Nanomaterials, and a Pathogen on a Model Soil Nematode Caenorhabditis elegans
by Jarad P. Cochran, Phocheng Ngy, Jason M. Unrine, Christopher J. Matocha and Olga V. Tsyusko
Nanomaterials 2024, 14(11), 913; https://doi.org/10.3390/nano14110913 - 23 May 2024
Viewed by 1190
Abstract
Previous research using the model soil nematode Caenorhabditis elegans has revealed that silver nanoparticles (AgNP) and their transformed counterpart, sulfidized AgNP (sAgNP), reduce their reproduction and survival. To expand our understanding of the environmental consequences of released NP, we examined the synergistic/antagonistic effects [...] Read more.
Previous research using the model soil nematode Caenorhabditis elegans has revealed that silver nanoparticles (AgNP) and their transformed counterpart, sulfidized AgNP (sAgNP), reduce their reproduction and survival. To expand our understanding of the environmental consequences of released NP, we examined the synergistic/antagonistic effects of AgNP and sAgNP along with AgNO3 (ionic control) on C. elegans infected with the pathogen Klebsiella pneumoniae. Individual exposures to each stressor significantly decreased nematode reproduction compared to controls. Combined exposures to equitoxic EC30 concentrations of two stressors, Ag in nanoparticulate (AgNP or sAgNP) or ionic form and the pathogen K. pneumoniae, showed a decline in the reproduction that was not significantly different compared to individual exposures of each of the stressors. The lack of enhanced toxicity after simultaneous combined exposure is partially due to Ag decreasing K. pneumoniae pathogenicity by inhibiting biofilm production outside the nematode and significantly reducing viable pathogens inside the host. Taken together, our results indicate that by hindering the ability of K. pneumoniae to colonize the nematode’s intestine, Ag reduces K. pneumoniae pathogenicity regardless of Ag form. These results differ from our previous research where simultaneous exposure to zinc oxide (ZnO) NP and K. pneumoniae led to a reproduction level that was not significantly different from the controls. Full article
(This article belongs to the Special Issue Toxicity Evaluation of Nanoparticles: 2nd Edition)
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