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Molecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Emerging Horizons of Hyperpolarization in Chemistry and Biomedicine
edited by
submission deadline 31 Aug 2026 | 3 articles | Viewed by 1534 | Submission Open
Keywords: hyperpolarization; NMR; MRI; low cost; SABRE; PHIP; d-DNP; isotopic enrichment
Applications of Solid-Phase Microextraction and Related Techniques, the Second Edition
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1090 | Submission Open
Keywords: solid-phase microextraction; micriextraction techniques; extraction sorbents; pharmaceutical analysis; forensic analysis; bioanalysis; environmental analysis; food analysis
(This special issue belongs to the Section Analytical Chemistry)
Modern Application of Cycloaddition Reactions: Experimental and Theoretical Research
edited by and Patricia Perez
submission deadline 31 Aug 2026 | 1 articles | Viewed by 950 | Submission Open
Keywords: cycloaddition reactions; molecular electron density theory; density functional theory; reaction mechanism; organic synthesis; bioactive compounds; biological activity of heterocyclic compounds
(This special issue belongs to the Section Organic Chemistry)
Chemical Composition and Biological Activity of Essential Oils and Other Extracts: From Extraction to Application Second Edition
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 738 | Submission Open
Keywords: medicinal and aromatica plant resources; plant extracts; essential oils; secondary metabolites; chromatography; mass spectrometry; bioactivity; synergism; application
(This special issue belongs to the Section Natural Products Chemistry)
Isolation and Structure Determination of Bioactive Natural Products, Third Edition submission deadline 31 Aug 2026 | Viewed by 156 | Submission Open
Keywords: primary and secondary plant metabolites; sample preparation methods; hyphenated analytical methods; natural product research; measuring biological activity; structure– activity relationships
(This special issue belongs to the Section Natural Products Chemistry)
Natural and Synthetic Bioactive Compounds in Food—Risks and Benefits
edited by
submission deadline 31 Aug 2026 | Viewed by 117 | Submission Open
Keywords: bioactive compounds; health; safety; effects; toxicology; biology; food; feed
(This special issue belongs to the Section Medicinal Chemistry)
Surface Modification of Materials and Their Applications
edited by
submission deadline 31 Aug 2026 | Viewed by 90 | Submission Open
Keywords: chemical functionalization; surface modification; catalysis; biotechnology; advanced manufacturing; environment
(This special issue belongs to the Section Materials Chemistry)
Natural Products and Their Derivatives with Applications in Health and Diseases
edited by and
submission deadline 31 Aug 2026 | Viewed by 68 | Submission Open
Keywords: natural products; medicinal plants; bioactive compounds; biological activity; mechanism of action; drug development; dietary supplements; healthy food
(This special issue belongs to the Section Natural Products Chemistry)
Catalytic Materials from Wastes for Environmental Pollution Control
edited by , Maria Victoria Gallegos and Franco Dubois
submission deadline 31 Aug 2026 | Viewed by 50 | Submission Open
Keywords: waste valorization; heterogeneous catalysis; environmental remediation; circular economy; sustainable energy
(This special issue belongs to the Section Materials Chemistry)
Antioxidant Properties of Bioactive Compounds from Plants submission deadline 31 Aug 2026 | Viewed by 48 | Submission Open
Keywords: reactive oxidant species; antioxidant protocols; antioxidant compounds; factors of influence; diseases
(This special issue belongs to the Section Natural Products Chemistry)
Exploring Agri-Food By-Products: From Novel Extraction to Bioactive Properties
edited by
submission deadline 31 Aug 2026 | Viewed by 40 | Submission Open
Keywords: agri-food by-products; bioactive compounds; novel extraction methods; phytochemicals; antioxidant properties
(This special issue belongs to the Section Food Chemistry)
New Sights in Stereoselective Synthesis
edited by , and Francesca Franco
submission deadline 31 Aug 2026 | Viewed by 29 | Submission Open
Keywords: asymmetric synthesis; organocatalysis; metal-based catalysts; chiral reagents; enzymatic reactions; synthesis in alternative biodegradable solvents; light-driven reactions; biocatalysis; electrochemical organic synthesis; continuous flow reactions
(This special issue belongs to the Section Organic Chemistry)
Recent Advances in Nucleic-Acid Based Drugs Development submission deadline 31 Aug 2026 | Viewed by 15 | Submission Open
Keywords: nucleic acids; oligonucleotide synthesis; modified nucleic acids; therapeutic applications; gene expression regulation; precision medicine; undruggable target
(This special issue belongs to the Section Medicinal Chemistry)
Metal Organic Frameworks (MOFs): Current Advances and Future Perspectives
edited by Bhausaheb Dhokale
submission deadline 31 Aug 2026 | Viewed by 9 | Submission Open
Keywords: metal– organic frameworks (MOFs); porous materials; catalysis; gas storage; drug delivery; hybrid materials; post-synthetic modification
(This special issue belongs to the Section Materials Chemistry)
Carbon-Based Electrochemical Materials for Energy Storage, 2nd Edition
edited by Huicong Xia
submission deadline 1 Sep 2026 | Viewed by 60 | Submission Open
Keywords: carbon-based nanomaterials; energy storage; batteries; supercapacitors; fuel cells; electrochemical reactions
(This special issue belongs to the Section Electrochemistry)
Protein–Ligand Interactions, 2nd Edition submission deadline 15 Sep 2026 | Viewed by 29 | Submission Open
Keywords: protein– ligand interactions; binding affinity; protein structure and function
(This special issue belongs to the Section Chemical Biology)
Metal Complexes for Optical and Electronics Applications submission deadline 30 Sep 2026 | 9 articles | Viewed by 18733 | Submission Open
Keywords: coordination chemistry; metal complexes; transition metals; lanthanides; luminescence; nonlinear optics; photo-switching; conductivity
(This special issue belongs to the Section Applied Chemistry)
Novel Heterocyclic Compounds: Synthesis and Applications
edited by and José Luis Viveros-Ceballos
submission deadline 30 Sep 2026 | 1 articles | Viewed by 2320 | Submission Open
Keywords: heterocyclic compounds; synthetic methodologies; medicinal chemistry; bioactive molecules; pharmaceutical applications; catalysis in heterocycle synthesis; green chemistry approaches; structure– activity relationships (SARs); organic synthesis; agrochemical applications
(This special issue belongs to the Section Organic Chemistry)
Design and Synthesis of Antiviral Drugs Targeting Enzymes of Emerging RNA Viruses submission deadline 30 Sep 2026 | Viewed by 346 | Submission Open
Keywords: antivirals; RNA viruses; viral replication; drug design; enzyme inhibitors
(This special issue belongs to the Section Medicinal Chemistry)
Advances in Emerging Photovoltaic: From Materials and Devices to Modules
edited by
submission deadline 30 Sep 2026 | Viewed by 52 | Submission Open
Keywords: design and synthesis of photovoltaic materials; perovskite photovoltaics; organic photovoltaics; quantum dot solar cells; scalability and stability
(This special issue belongs to the Section Materials Chemistry)
Recent Research Progress of Novel Ion Adsorbents—2nd Edition submission deadline 30 Sep 2026 | Viewed by 29 | Submission Open
Keywords: synthesis of adsorbents; adsorbents regeneration; ionic adsorbates; purification of water; removal of impurities; adsorption mechanisms; desorption; equilibrium data; adsorption isotherms; kinetic models
(This special issue belongs to the Section Physical Chemistry)
Organic Synthesis and Medicinal Chemistry, Two Inseparable Partners: Recent Advances in Heterocyclic Chemistry, 2nd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 20 | Submission Open
Keywords: organic chemistry methods; organic synthesis; medicinal chemistry; heterocycles; drug discovery; in silico drug design; biologically active compounds
(This special issue belongs to the Section Medicinal Chemistry)
Metal-Catalyzed Organic Transformations: Expanding Horizons in Synthetic Methodology—2nd Edition
edited by Chen Chen and
submission deadline 30 Sep 2026 | Viewed by 19 | Submission Open
Keywords: multicomponent reactions; transition metal catalysis; organometallic chemistry; electrosynthesis; photocatalysis; green organic synthesis; bioactive molecules
(This special issue belongs to the Section Organic Chemistry)
Sustainable Chemistry with Ionic Liquids and Deep Eutectic Solvents: From Fundamentals to Applications
edited by
submission deadline 30 Sep 2026 | Viewed by 2 | Submission Open
Keywords: ionic liquids; deep eutectic solvents; green chemistry; sustainable solvents; electrolytes; catalysis; electrochemistry; biomass; extraction
(This special issue belongs to the Section Molecular Liquids)
Lignocellulosic Biomass Utilization: From Waste to Value-Added Products submission deadline 1 Oct 2026 | Viewed by 60 | Submission Open
Keywords: lignocellulosic biomass; value-added products; biomaterials; biorefinery; circular economy; bioenergy; sustainable development goals; green chemistry
(This special issue belongs to the Section Green Chemistry)
Recent Advances in Exploiting Ionic Liquids for Biocatalytic and Pharmaceutical Application
edited by and
submission deadline 31 Oct 2026 | 6 articles | Viewed by 17492 | Submission Open
Keywords: ionic liquids; nanomaterials; emulsions; biological activity; biocatalysis; active pharmaceutical ingredients; drug delivery; mechanism of action; toxicity; pharmaceuticals; enzymes
(This special issue belongs to the Section Molecular Liquids)
5th Anniversary of Section "Flavours and Fragrances" and 30th Anniversary of Molecules
edited by
submission deadline 31 Oct 2026 | 6 articles | Viewed by 9094 | Submission Open
Keywords: flavor; aroma; taste; fragrances; volatilomics; flavoromics; sensomics; food flavors; analysis of flavor compounds
(This special issue belongs to the Section Flavours and Fragrances)
Insights on Inorganic/Organic Composites Containing Natural Bioactive Molecules
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 5811 | Submission Open
Keywords: hybrid material; composite; natural compound; clay; drug delivery system; solid phase adsorption; bioactivity
(This special issue belongs to the Section Natural Products Chemistry)
Targeting Cell Signaling Pathways in Drug Discovery
edited by
submission deadline 31 Oct 2026 | Viewed by 36 | Submission Open
Keywords: targeted therapy; non-communicable diseases; enzymes; synthetic compounds; natural extracts; molecular modeling; chemically modified drugs; cellular key targets
(This special issue belongs to the Section Chemical Biology)
Trends in Biosensors for Biomedical Applications submission deadline 31 Oct 2026 | Viewed by 30 | Submission Open
Keywords: optical biosensors (SPR; SERS; fluorescence; colorimetric); electrochemical biosensors; nanogravimetric biosensors; immunosensors; DNA-based biosensors; aptamer-based biosensors; exosomal biomarkers; enzymatic-biosensors
(This special issue belongs to the Section Chemical Biology)
Discovering the Pharmacological and Medicinal Potentials of Plant Flavonoids and Other Polyphenols from Nature submission deadline 31 Oct 2026 | Viewed by 28 | Submission Open
Keywords: flavonoids; polyphenols; natural product; anti-aging; anti-oxidative stress; anti-cancer; pharmacological activity; medical application
(This special issue belongs to the Section Natural Products Chemistry)
Featured Reviews on Bioactive Flavour and Fragrance Compounds, 2nd Edition
edited by
submission deadline 31 Oct 2026 | Viewed by 24 | Submission Open
Keywords: essential oils; agriculture; food; formulations; crop protection; insecticides; extraction techniques; chemical characterization; biological activity
(This special issue belongs to the Section Flavours and Fragrances)
Starch: Chemistry, Technology, and Application—2nd Edition
edited by
submission deadline 31 Oct 2026 | Viewed by 20 | Submission Open
Keywords: starch modification; starch complexes; resistant starch; digestibility; precision nutrition; green technology; structure– function relationship
(This special issue belongs to the Section Food Chemistry)
Advances in Alkyne Chemistry
edited by Ruimao Hua
submission deadline 25 Nov 2026 | 7 articles | Viewed by 31458 | Submission Open
Keywords: alkyne annulation; carbocycle synthesis; heterocycle synthesis; atom-economic reaction; synthesis methodology
(This special issue belongs to the Section Organic Chemistry)
30th Anniversary of Molecules—Recent Advances in Materials Chemistry
edited by , and Mu-Ping Nieh
submission deadline 30 Nov 2026 | 11 articles | Viewed by 15631 | Submission Open
Keywords: materials chemistry; synthetic procedures; characterization procedures; nanomaterials and nanocomposites; biologically oriented materials and biomaterials; materials of natural origin; hybrid composites; mechanical properties; long-term durability
(This special issue belongs to the Section Materials Chemistry)
Heterophase Polymerization and Functional Polymer Microspheres/Microcapsules
edited by Chengyou Kan and Wei Deng
submission deadline 30 Nov 2026 | 6 articles | Viewed by 10357 | Submission Open
Keywords: emulsion polymerization; mini emulsion polymerization; dispersion polymerization; suspension polymerization; encapsulation; functionalization; polymer microspheres; microcapsules; characterization; morphology control; structure– property relationship; polymer nanocomposite; application
(This special issue belongs to the Section Materials Chemistry)
30th Anniversary of Molecules—Recent Advances in Computational and Theoretical Chemistry
edited by
submission deadline 30 Nov 2026 | 5 articles | Viewed by 6615 | Submission Open
Keywords: computational chemistry; quantum chemistry; density functional theory; molecular design; reaction mechanism; chemical bonding; non-covalent interactions; molecular docking
(This special issue belongs to the Section Computational and Theoretical Chemistry)
Bioactive Components in Plants: Extraction, Characterization and Antioxidant Activity
edited by
submission deadline 15 Dec 2026 | Viewed by 42 | Submission Open
Keywords: bioactive compounds; plant extracts; extraction of bioactives; polyphenols; chemical characterization; antioxidant activity; green chemistry
(This special issue belongs to the Section Natural Products Chemistry)
Characterization of Organic Ligands: Correlations Between Results by Electrochemistry and Other Methods
edited by Eleonora-Mihaela Ungureanu
submission deadline 20 Dec 2026 | 1 articles | Viewed by 658 | Submission Open
Keywords: connections; electrochemical experiments; characterization of organic ligands; DFT calculations of ligand properties; optical methods; electrochemical methods; surface characterization methods (SEM; AFM; Raman; etc.); analytical methods
(This special issue belongs to the Section Applied Chemistry)
30th Anniversary of Molecules: Recent Advances and the Next in Macromolecular Chemistry submission deadline 31 Dec 2026 | 8 articles | Viewed by 13400 | Submission Open
Keywords: macromolecular chemistry; synthetic polymers; natural polymers; polymerization mechanisms and kinetics; supramolecular self-assembly; biological macromolecules
(This special issue belongs to the Section Macromolecular Chemistry)
30th Anniversary of Molecules—Recent Advances in Inorganic Chemistry submission deadline 31 Dec 2026 | 9 articles | Viewed by 8195 | Submission Open
Keywords: inorganic chemistry; coordination chemistry; solid-state chemistry; nanomaterials; organometallics; transition and main group metal chemistry; catalysis; bioinorganic chemistry
(This special issue belongs to the Section Inorganic Chemistry)
30th Anniversary of Molecules—Recent Advances in Analytical Chemistry submission deadline 31 Dec 2026 | 2 articles | Viewed by 4271 | Submission Open
Keywords: chromatography and advanced mass spectrometry; atomic spectroscopy and elemental mass spectrometry; molecular spectroscopy; miniaturization of analytical instruments; ohmics; nanomaterials and sensors; automation and high-throughput screening; single-cell analysis; non-invasive analysis/techniques; green analytical chemistry
(This special issue belongs to the Section Analytical Chemistry)
30th Anniversary of Molecules—Recent Developments in Biobased Polymers submission deadline 31 Dec 2026 | 2 articles | Viewed by 2386 | Submission Open
Keywords: biobased polymers; sustainability; biodegradability; polymer recycling; polymer composites; polymer processing; green chemistry
(This special issue belongs to the Section Materials Chemistry)
30th Anniversary of Molecules: Recent Advances in Organometallic Chemistry
edited by
submission deadline 31 Dec 2026 | 2 articles | Viewed by 2077 | Submission Open
Keywords: metal– organic framework; organometallic compounds; coordination assembly; metal– organic cluster; metal– organic cage; supramolecular chemistry
(This special issue belongs to the Section Organometallic Chemistry)
Functional Molecules Design for Nutrition Health
edited by and
submission deadline 31 Dec 2026 | Viewed by 62 | Submission Open
Keywords: molecule design; biological activity; nutrition and health; personalized nutrition protocols; precision therapeutic methods
(This special issue belongs to the Section Materials Chemistry)
Synthesis of Innovative and Smart Materials for Batteries
edited by and Kangyu Zou
submission deadline 31 Dec 2026 | Viewed by 38 | Submission Open
Keywords: batteries; energy storage; electrodes; materials design; smart functional components
(This special issue belongs to the Section Materials Chemistry)
Electrochemical Approaches in Bioanalysis: Translational Applications in Medicine and Environmental Monitoring
edited by Mihaela Tertis
submission deadline 31 Dec 2026 | Viewed by 34 | Submission Open
Keywords: electrochemical bioanalysis; sensors and biosensors; nanomaterials and biomimetic-based platforms; point-of-care diagnostics; environmental monitoring
(This special issue belongs to the Section Electrochemistry)
30th Anniversary of Molecules—Recent Advances in Electrochemistry
edited by
submission deadline 31 Dec 2026 | Viewed by 33 | Submission Open
Keywords: electrochemical science; energy conversion; charge transfer; voltammetry; magnetoelectrochemistry/spin; redox chemistry
(This special issue belongs to the Section Electrochemistry)
Advances in Lactam Chemistry: From Synthetic Strategies to Biological Applications
edited by
submission deadline 31 Dec 2026 | Viewed by 33 | Submission Open
Keywords: lactams; sustainable synthesis; structure– activity relationship (SAR); drug discovery; β -lactam analogues; heterocyclic chemistry; therapeutic applications; antimicrobial and anticancer agents
(This special issue belongs to the Section Organic Chemistry)
Advances in Remediation Methods of Pharmaceutical Pollutants in Water submission deadline 31 Dec 2026 | Viewed by 1 | Submission Open
Keywords: drug pollutants; advanced oxidation processes; water treatment; electrochemical methods; photodegradation; degradation pathways; mineralization; toxicity assessment
(This special issue belongs to the Section Green Chemistry)
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