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Special Issue "Sea-Inspired Molecules"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 December 2020.

Special Issue Editor

Prof. Dr. Valeria Costantino
Website
Guest Editor
Università degli Studi di Napoli “Federico II”, Via D. Montesano, 49, 80131, Napoli, Italy
Interests: isolation and stereostructural elucidation of novel molecules from marine origin; molecular networking; leads mokecules in drug discovery; quorum sensing and quorum quenching molecules; cyanobateria-derived molecules; cyanobacteria toxins; poliketides/peptide mixed molecules
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Special Issue Information

Dear Colleagues,

Oceans comprise 71% of the surface area of the earth. Keeping this data in mind, it is easy to understand why natural product chemists have looked to marine organisms as a novel source of new molecules since the early 80s. The marine environment is an excellent reservoir of novel bioactive molecules because they have chemical features not found in terrestrial organisms.

In this Special Issue, we will collect really creative and original works related to unusual skeletons, halogenated molecules, sulfur molecules, and nitrogen molecules in the form of original research articles and reviews, isolated from marine macro- and microorganisms, as well as original methodologies used to assign absolute stereochemistry.

Because it is largely recognized that scientific works by women are often overlooked [1] despite the importance of authorship in determining careers, we would especially appreciate original contributions with the lead and/or corresponding author being a woman.


Prof. Valeria Costantino
Guest Editor

1. www.sciencedaily.com/releases/2019/02/190207102624.htm

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine organisms
  • molecules
  • halogenated compounds
  • sulfur compounds
  • nitrogen compounds
  • new inspiring skeletons

Published Papers (2 papers)

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Research

Open AccessFeature PaperArticle
New Chlorinated 2,5-Diketopiperazines from Marine-Derived Bacteria Isolated from Sediments of the Eastern Mediterranean Sea
Molecules 2020, 25(7), 1509; https://doi.org/10.3390/molecules25071509 - 26 Mar 2020
Abstract
From the organic extracts of five bacterial strains isolated from marine sediments collected in the East Mediterranean Sea, three new (15, 16, 31) and twenty-nine previously reported (114, 1730, 32) metabolites [...] Read more.
From the organic extracts of five bacterial strains isolated from marine sediments collected in the East Mediterranean Sea, three new (15, 16, 31) and twenty-nine previously reported (114, 1730, 32) metabolites bearing the 2,5-diketopiperazine skeleton were isolated. The structures of the chlorinated compounds 15, 16, and 31 were elucidated by extensive analysis of their spectroscopic data (NMR, MS, UV, IR). Compounds 15 and 16 were evaluated for their antifungal activity against Candida albicans and Aspergillus niger but were proven inactive. The relevant literature is supplemented with complete NMR assignments and revisions for the 29 previously reported compounds. Full article
(This article belongs to the Special Issue Sea-Inspired Molecules)
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Open AccessFeature PaperArticle
Total Synthesis of (–)-Anaferine: A Further Ramification in a Diversity-Oriented Approach
Molecules 2020, 25(5), 1057; https://doi.org/10.3390/molecules25051057 - 27 Feb 2020
Abstract
The piperidine ring is a widespread motif in several natural bioactive alkaloids of both vegetal and marine origin. In the last years, a diversity-oriented synthetic (DOS) approach, aimed at the generation of a library of piperidine-based derivatives, was developed in our research group, [...] Read more.
The piperidine ring is a widespread motif in several natural bioactive alkaloids of both vegetal and marine origin. In the last years, a diversity-oriented synthetic (DOS) approach, aimed at the generation of a library of piperidine-based derivatives, was developed in our research group, employing commercially available 2-piperidine ethanol as a versatile precursor. Here, we report the exploration of another ramification of our DOS approach, that led us to the stereoselective total synthesis of (–)-anaferine, a bis-piperidine alkaloid present in Withania somnifera extract. This natural product was obtained in 9% overall yield over 13 steps, starting from a key homoallylic alcohol previously synthesised in our laboratory. Therefore, the collection of piperidine-derivatives accessible from 2-piperidine ethanol was enriched with a new, diverse scaffold. Full article
(This article belongs to the Special Issue Sea-Inspired Molecules)
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