Protein Domains: Structures and Molecular Functions

Dear Colleagues,

Protein domains are modular units in terms of either structural, functional, or evolutionary aspects. After the completion of human genome projects, it was shown that more than 70% of the genes are encoding multidomain proteins with two or more domains. Understanding of structure–function relationships of the individual domains should lead to the illumination new physiological functions of unknown genes. We are motivated by this idea to develop methods for high-throughput structure determination, structure prediction, accurate modelling, molecular dynamic simulation, and the prediction of functions. The accumulation of knowledge of the structure and function of protein domains is still being continued and is providing an important basis for structure-guided drug discovery, protein therapeutics, genome-based diagnosis, designed proteins, molecular beacons and sensors, and synthetic biology. This Special Issue focuses on recent advances in the domain-centric analysis of proteins in the field of biochemistry, bioinformatics and biophysics. In addition, either the analysis of natural domain pairs (architectures) or the design of artificial multi-domain proteins are in focus. Original research papers, concise reviews, and perspectives are welcome.

Prof. Dr. Hidekazu Hiroaki
Dr. Kentaro Tomii
Guest Editors

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