Special Issue "Antimicrobial Peptides and Peptidomimetics"
Deadline for manuscript submissions: closed (31 May 2018).
Assoc. Prof. Steven L. Cobb
Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK
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Interests: chemical-biology of peptides; organic synthesis; peptide and peptoid chemistry; bio-organic fluorine chemistry; bio-conjugation; drug target validation; infectious disease and neglected tropical diseases
Our ability to treat what we currently consider minor bacterial infections underpins all of modern medicine and the future cost of failure to treat such infections is enormous both in terms of societal and economic impacts. The situation is exacerbated by the fact that the number of new antibiotics being brought to market is at an all-time low. There is an urgent need for new antibiotics that can be used to treat the rapid emergence of antimicrobial resistance.
The effectiveness of the innate immune system in providing the first line of defence against infection, has led main research groups around the world to investigate the activities of antimicrobial peptides (AMPs), with a view to their use as templates for the design of innovative therapeutics to combat emerging antimicrobial resistance. However, despite their considerable promise in terms of biological activity, efforts to develop AMPs as generic antibiotics have been hampered by their inherent chemical instability and susceptibility to enzymatic degradation. Only a handful of AMPs are currently in clinical trials.
This Special Issue is aimed at covering recent advances in the synthesis, mechanistic understanding and applications of antimicrobial peptides (and peptidomimetics) in the development of new agents for the treatment of microbial infections.Assoc. Prof. Steven L Cobb
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Microbial Infection (bacterial, fungal and parasitic)
- Antimicrobial Peptides
- Mode of action
- Structure and properties