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Special Issue "Discovery, Design, Synthesis, and Application of Nucleoside/Nucleotides"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: 31 May 2019

Special Issue Editor

Guest Editor
Prof. Katherine L. Seley-Radtke

Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA
Website | E-Mail
Interests: nucleos(t)ides; heterocycles; drug design; enzyme inhibitors; antiviral

Special Issue Information

Dear Colleagues,

For decades, nucleosides and nucleotides have formed the cornerstone of antiviral and anticancer therapeutics. In addition, some analogues have also made progress against parasites and bacteria and in other areas. This phenomenon is a direct result of their close structural similarity to naturally occurring nucleosides. As such, any changes to their diverse scaffolds can have profound effects. In general, nucleoside and nucleotide analogues target key biological pathways in the replication cycles of many diseases; However, some have also been shown to target human enzymes, which can sometimes result in deleterious consequences. In this regard, the primary issue with this class of drugs involves selectivity. A second major issue with this class of drugs is the often-times rapid development of resistance. As a result, there is a constant need for new and more effective analogues to fight emerging and reemerging infectious diseases and cancers; thus, this Special Issue will focus on some of the leading approaches to design, synthesis, and biological investigations, as well as the various applications for this highly relevant class of compounds and their corresponding prodrugs.

Prof. Katherine Seley-Radtke
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nucleosides
  • Nucleotides
  • Prodrugs
  • Antiviral
  • Anticancer
  • Enzyme inhibitors

Published Papers (3 papers)

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Research

Open AccessCommunication Next Generation Sequencing-Based Molecular Marker Development: A Case Study in Betula Alnoides
Molecules 2018, 23(11), 2963; https://doi.org/10.3390/molecules23112963
Received: 30 September 2018 / Revised: 9 November 2018 / Accepted: 11 November 2018 / Published: 13 November 2018
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Abstract
Betula alnoides is a fast-growing valuable indigenous tree species with multiple uses in the tropical and warm subtropical regions in South-East Asia and southern China. It has been proved to be tetraploid in most parts of its distribution in China. In the present
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Betula alnoides is a fast-growing valuable indigenous tree species with multiple uses in the tropical and warm subtropical regions in South-East Asia and southern China. It has been proved to be tetraploid in most parts of its distribution in China. In the present study, next generation sequencing (NGS) technology was applied to develop numerous SSR markers for B. alnoides, and 64,376 contig sequences of 106,452 clean reads containing 164,357 candidate SSR loci were obtained. Among the derived SSR repeats, mono-nucleotide was the main type (77.05%), followed by di- (10.18%), tetra- (6.12%), tri- (3.56%), penta- (2.14%) and hexa-nucleotide (0.95%). The short nucleotide sequence repeats accounted for 90.79%. Among the 291 repeat motifs, AG/CT (46.33%) and AT/AT (44.15%) were the most common di-nucleotide repeats, while AAT/ATT (48.98%) was the most common tri-nucleotide repeats. A total of 2549 primer sets were designed from the identified putative SSR regions of which 900 were randomly selected for evaluation of amplification successfulness and detection of polymorphism if amplified successfully. Three hundred and ten polymorphic markers were obtained through testing with 24 individuals from B. alnoides natural forest in Jingxi County, Guangxi, China. The number of alleles (NA) of each marker ranged from 2 to 19 with a mean of 5.14. The observed (HO) and expected (HE) heterozygosities varied from 0.04 to 1.00 and 0.04 to 0.92 with their means being 0.64 and 0.57, respectively. Shannon-Wiener diversity index (I) ranged from 0.10 to 2.68 with a mean of 1.12. Cross-species transferability was further examined for 96 pairs of SSR primers randomly selected, and it was found that 48.96–84.38% of the primer pairs could successfully amplify each of six related Betula species. The obtained SSR markers can be used to study population genetics and molecular marker assisted breeding, particularly genome-wide association study of these species in the future. Full article
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Open AccessArticle Novel 5′-Norcarbocyclic Derivatives of Bicyclic Pyrrolo- and Furano[2,3-d]Pyrimidine Nucleosides
Molecules 2018, 23(10), 2654; https://doi.org/10.3390/molecules23102654
Received: 3 September 2018 / Revised: 28 September 2018 / Accepted: 12 October 2018 / Published: 16 October 2018
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Abstract
Here we report the synthesis and biological activity of new 5′-norcarbocyclic derivatives of bicyclic pyrrolo- and furano[2,3-d]pyrimidines with different substituents in the heterocyclic ring. Lead compound 3i, containing 6-pentylphenyl substituent, displays inhibitory activity with respect to a number of tumor cells with
[...] Read more.
Here we report the synthesis and biological activity of new 5′-norcarbocyclic derivatives of bicyclic pyrrolo- and furano[2,3-d]pyrimidines with different substituents in the heterocyclic ring. Lead compound 3i, containing 6-pentylphenyl substituent, displays inhibitory activity with respect to a number of tumor cells with a moderate selectivity index value. Compound 3i induces cell death by the apoptosis pathway with the dissipation of mitochondrial potential. Full article
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Graphical abstract

Open AccessFeature PaperArticle 2′-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA
Molecules 2018, 23(10), 2572; https://doi.org/10.3390/molecules23102572
Received: 5 September 2018 / Revised: 28 September 2018 / Accepted: 7 October 2018 / Published: 9 October 2018
PDF Full-text (3783 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
In contrast to Z-DNA that was stabilized and well-studied for its structure by chemical approaches, the stabilization and structural study of Z-RNA remains a challenge. In this study, we developed a Z-form RNA stabilizer m8Gm, and demonstrated that incorporation of m
[...] Read more.
In contrast to Z-DNA that was stabilized and well-studied for its structure by chemical approaches, the stabilization and structural study of Z-RNA remains a challenge. In this study, we developed a Z-form RNA stabilizer m8Gm, and demonstrated that incorporation of m8Gm into RNA can markedly stabilize the Z-RNA at low salt conditions. Using the m8Gm-contained Z-RNA, we determined the structure of Z-RNA and investigated the interaction of protein and Z-RNA. Full article
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