Special Issue "Discovery, Design, Synthesis, and Application of Nucleoside/Nucleotides"
Deadline for manuscript submissions: 31 May 2019
Assoc. Prof. Theodore K. Dayie
For decades, nucleosides and nucleotides have formed the cornerstone of antiviral and anticancer therapeutics. In addition, some analogues have also made progress against parasites and bacteria and in other areas. This phenomenon is a direct result of their close structural similarity to naturally occurring nucleosides. As such, any changes to their diverse scaffolds can have profound effects. In general, nucleoside and nucleotide analogues target key biological pathways in the replication cycles of many diseases; However, some have also been shown to target human enzymes, which can sometimes result in deleterious consequences. In this regard, the primary issue with this class of drugs involves selectivity. A second major issue with this class of drugs is the often-times rapid development of resistance. As a result, there is a constant need for new and more effective analogues to fight emerging and reemerging infectious diseases and cancers; thus, this Special Issue will focus on some of the leading approaches to design, synthesis, and biological investigations, as well as the various applications for this highly relevant class of compounds and their corresponding prodrugs.
Prof. Katherine Seley-Radtke
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Enzyme inhibitors
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Studies on the Molecular Mechanism of foot-and mouth disease virus-VPg (FMDV-VPg) inhibition by FUTP
Article Type: Article
Author: María‐José Camarasa
Title: Carbocyclic nucleoside analogues with an optically active norbornane fragment linked to the base by a methylen group, as an glycoside moiety
Article Type: Article
Author: Constantin Tanase
Abstract: Nucleoside analogues with a non-cyclic glycoside moiety are known as recognized antiviral drugs. Some nucleoside analogues with a cyclobutate or a cyclopentane fragment spaced from the base by a methylene group are also mentioned in the literature. In this paper we present another type of carbocyclic nucleoside analogues that contain an optically active norbornane fragment, substituted by a chlorine and a hydroxyl group, spaced to the base moiety by a methylene group.
The synthesis, characterization and preliminary screening of their antiviral activity will be described.