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Novel 5′-Norcarbocyclic Derivatives of Bicyclic Pyrrolo- and Furano[2,3-d]Pyrimidine Nucleosides

1
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia
2
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 8 Lavrentiev Ave., Novosibirsk 630090, Russia
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(10), 2654; https://doi.org/10.3390/molecules23102654
Received: 3 September 2018 / Revised: 28 September 2018 / Accepted: 12 October 2018 / Published: 16 October 2018
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Abstract

Here we report the synthesis and biological activity of new 5′-norcarbocyclic derivatives of bicyclic pyrrolo- and furano[2,3-d]pyrimidines with different substituents in the heterocyclic ring. Lead compound 3i, containing 6-pentylphenyl substituent, displays inhibitory activity with respect to a number of tumor cells with a moderate selectivity index value. Compound 3i induces cell death by the apoptosis pathway with the dissipation of mitochondrial potential. View Full-Text
Keywords: 5′-norcarbocyclic nucleoside analogues; antiproliferative properties; structure–activity relationship 5′-norcarbocyclic nucleoside analogues; antiproliferative properties; structure–activity relationship
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Klimenko, A.A.; Matyugina, E.S.; Logashenko, E.B.; Solyev, P.N.; Zenkova, M.A.; Kochetkov, S.N.; Khandazhinskaya, A.L. Novel 5′-Norcarbocyclic Derivatives of Bicyclic Pyrrolo- and Furano[2,3-d]Pyrimidine Nucleosides. Molecules 2018, 23, 2654.

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