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2′-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA

1
Division of Chemistry, Department of Medical Sciences, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
2
The key Laboratory of Optimal Utilization of Natural Medicine Resources, School of Pharmaceutical Sciences, Guizhou Medical University, University Town, Guian New District, Guiyang 550025, China
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(10), 2572; https://doi.org/10.3390/molecules23102572
Received: 5 September 2018 / Revised: 28 September 2018 / Accepted: 7 October 2018 / Published: 9 October 2018
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Abstract

In contrast to Z-DNA that was stabilized and well-studied for its structure by chemical approaches, the stabilization and structural study of Z-RNA remains a challenge. In this study, we developed a Z-form RNA stabilizer m8Gm, and demonstrated that incorporation of m8Gm into RNA can markedly stabilize the Z-RNA at low salt conditions. Using the m8Gm-contained Z-RNA, we determined the structure of Z-RNA and investigated the interaction of protein and Z-RNA. View Full-Text
Keywords: Z-RNA structure; synthesis of oligonucleotide; NMR; circular dichroism Z-RNA structure; synthesis of oligonucleotide; NMR; circular dichroism
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Balasubramaniyam, T.; Ishizuka, T.; Xiao, C.-D.; Bao, H.-L.; Xu, Y. 2′-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA. Molecules 2018, 23, 2572.

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