Special Issue "Ionic Liquids for Chemical and Biochemical Applications II"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: 31 December 2020.
Interests: ionic liquid electrolyte; electrodeposition; electrocatalysis; electroanalysis; modified electrode; electrochemical fabrication of nanostructures
Interests: alloying–dealloying technique; nanoporous structure; electrochemical detection; proton conductor; nanoparticle; electrocatalyst; electrocatalytic reaction; task-specific ionic liquid
Interests: newfangled ionic liquid; combinatorial organic synthesis; affinity ionic liquid; biomolecular recognition; functionalized ionic liquid; chemoselective gas analysis; bioorganic and bioanalytical chemistry
Special Issues and Collections in MDPI journals
Ionic liquids are ionic, nonvolatile alternatives to conventional volatile molecular solvents and have recently received impressive attention in many aspects of chemical, electrochemical, and biochemical applications.
This year, the journal Molecules is to publish the second edition of a Special Issue with a collection of papers featuring selected contributions from Ionic Liquids for Chemical and Biochemical Applications II. As guest editors of this Special Issue, we are writing to invite you to contribute a research paper, rapid communication, or review article on your latest research activities in ionic liquids.
This Special Issue will be a collection of papers focusing on ionic liquids as smart materials for electrocatalytic as well as electrochemical analysis, and ionic liquid devices for affinity extraction and analysis. We anticipate that this issue will be attractive to the scientific community of synthesis, materials, and separation, and we invite contributions covering the aspects broadly indicated by the keywords. Reviews articles by experts are also welcomed.
Prof. Dr. Po-Yu Chen
Prof. Dr. Jing-Fang Huang
Prof. Dr. Yen-Ho Chu
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Ionic liquid
- Ionic liquid electrolyte
- Electrochemical fabrication of nanostructures
- Protic ionic liquid
- Materials in ionic liquid
- Ionic solvent
- Organic reaction
- Natural product in ionic liquid
- Gas sensing
- Affinity extraction
- Chromatographic separation
- Zwitterionic liquid
- Functional ionic liquid
- Enzymatic catalysis
- DNA, protein, peptide, and carbohydrate
- Desalination and water treatment
- Polymer dissolution
- Oil extraction
- Task-specific ionic liquid
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of the paper: Communication
Tentative title: Alternating current electrodeposition of poly(3,4-ethylenedioxythiophene) from protic ionic liquids to construct organic electrochemical transistors
Authors: Jianlong Ji 1,*, Xiaoxian Zhu 1, Er Hua 2,*, Shengbo Sang 1, Zhengdong Cheng 3
Affiliations: 1 College of Information and Computer, Taiyuan University of Technology, Taiyuan 030024, China
2 Chemical Science and Engineering College, North Minzu University, Ningxia 750021, China
3 Artie McFerrin Department of Chemical Engineering, Texas A & M University, Texas 77843, USA
Abstract: Poly (3,4-ethylenedioxythiophene) (PEDOT) based organic electrochemical transistors (OECTs) are usually utilized to construct highly sensitive biosensors. In this work, the PEDOT channel-layer of the OECT was prepared by alternating current (AC) electrodeposition of ethylenedioxythiophene (EDOT) monolayer in the protic ionic liquid. The PEDOT channel-layer was prepared between the microelectrodes having a gap of 10 microns on the silicon dioxide substrate. Raman spectroscopy demonstrates that the anion of the ionic liquid was deposited as a dopant in the PEDOT channel-layer. Through this method, we obtained a high on/off ratio (1000) OECT, which was promising to be used as the low-power biosensors.
Type of the paper: Article
Tentative title: Ionic Liquid Matrices for Soft Ionization in Matrix-Assisted Laser Desorption/Ionization (MALDI)
Authors: Chih-Hao Lin, I-Chung Lu*
Affiliations: Department of Chemistry, National Chung Hsing University, Taichung City, Taiwan
Abstract: Mass spectrometry (MS) has outstanding potential in analytical chemistry these two decades. To ionize the analyte efficiently, most of the conventional ionization technique apply additional energy such as photons, heat, or the electrical potential to produce ions for mass analysis. However, these excess energies might induce fragmentation because of the increased internal energy. For example, matrix-assisted laser desorption/ionization (MALDI) employs small molecules as a matrix to absorb photon energy. The analyte is then ionized and desorbed into gas phase for sample analysis by a mass spectrometer. Although MALDI has been widely used as a soft ionization technique in mass spectrometry, it is still incapable of observing the labile biomolecule. Ionic liquids can be MALDI matrices and solvents for the analyte. It showed high stability with negligible sublimation under vacuum and excellent capability for quantitative analyses previously. In this study, we compared the conventional matrices of MALDI with ionic liquid matrices to demonstrate a softer characteristic of ionization, providing fewer fragments during the ionization processes. The results showed a potential method to observe intact biomolecules based on the ionic liquids.
Tentative title: Globular and fibrous proteins modified with deep eutectic solvents
Authors: Wanwan Qu, Riina Häkkinen, Jack Allen, Carmine D’Agostino and Andrew P. Abbott*
1. School of Chemistry, University of Leicester, University Road, Leicester LE1 7RH,
2. VTT Technical Research Centre of Finland Ltd, Tietotie 4 E, FI-02150 VTT, Finland
3. School of Chemical Engineering and Analytical Science, University of Manchester, Oxford Rd, Manchester, M13 9PL, UK
Abstract: Proteinaceous materials have numerous structures, many of which aid in the roles they perform. Some need to impart strength while others need elasticity or toughness. This study is the first to investigate the modification of both globular and fibrous protein, namely, zein, soy protein and gelatin, using deep eutectic solvents (DES) to form bioplastics which may have application in drug delivery systems. The effects of DES content on the thermal and mechanical properties of the material were determined. Zein and soy are globular proteins which both showed a significant change in the properties by the addition of DES. Both of these materials were, however, weaker and less ductile than the starch based materials previously reported in the literature. The material made from gelatin, a fibrous protein, showed variable properties depending on how long they were in contact with each other before pressing. Conductivity and NMR measurements indicate the existence of a continuous phase which are useful in the demonstrated application of transdermal drug delivery systems.
Title: Comparison of Chemotherapeutic Activities of Rhodamine based GUMBOS and nanoGUMBOS
Authors: Dr. Nimisha Bhattarai,a,1 Dr. Mi Chen,a,2 Dr. Rocío L. Pérez,a Dr. Sudhir Ravula,a,3 Dr. Robert M. Strongin,b Karen McDonough,c and Dr. Isiah M. Warner a*
Affiliation: aDepartment of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA bDepartment of Chemistry, Portland State University, Portland, OR 97207, USA cAgCenter Biotechnology Labs, Louisiana State University, Baton Rouge, LA 70803, USA. 1 Present address - Department of Biochemistry and Molecular Biology, School of Medicine, Tulane University, New Orleans, LA 70118. 2 Present address – Pharmaceutical Product Development Bioanalytical Laboratory, Middleton, WI 53562. 3 Present address - Louisiana State University Health Sciences Center New Orleans, New Orleans, LA 70112. * Corresponding Author: Isiah M. Warner, email: [email protected], Phone: 225-578-2829, Fax: 225-578-3971
Abstract: Rhodamine derivatives have been widely investigated for their mitochondrial targeting and chemotherapeutic properties that result from their lipophilic cationic structures. In previous research, we have found that conversion of Rhodamine 6G into nanoGUMBOS, i.e. nanomaterials derived from a group of uniform materials based on organic salts (GUMBOS), led to selective chemotherapeutic toxicity for cancer cells over normal cells. Herein, we investigate the chemotherapeutic activity of GUMBOS derived from four different rhodamine derivatives, two bearing an ester group, i.e. Rhodamine 123 (R123) and SNAFR-5, and two bearing a carboxylic acid group, i.e. rhodamine 110 (R110) and rhodamine B (RB). In this study, we evaluate 1) relative hydrophobicity via octanol-water partition coefficients, 2) cytotoxicity, and 3) cellular uptake in order to evaluate possible structure activity relationship between these different compounds. Intriguingly, we found that while GUMBOS derived from R123 and SNAFR-5 formed nanoGUMBOS in aqueous medium, no distinct nanoparticles are observed for RB and R110 GUMBOS. Further investigation revealed that the relatively high water solubility of R110 and RB GUMBOS hinders nanoparticle formation. Subsequently, while R123 and SNAFR-5 displayed selective chemotherapeutic toxicity similar to that of previously investigated R6G nanoGUMBOS, the R110 and RB GUMBOS were lacking in this property. Additionally, the chemotherapeutic toxicities of R123 and SNAFR-5 nanoGUMBOS were also significantly greater than R110 and RB GUMBOS. Observed results were consistent with decreased cellular uptake of R110 and RB as compared to R123 and SNAFR-5 compounds. Moreover, these results are also consistent with previous observations that suggest that nanoparticle formation is critical to the observed selective chemotherapeutic properties as well as chemotherapeutic efficacy of rhodamine nanoGUMBOS.