Special Issue "Bioactivity of Inositol Phosphates"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: 15 September 2020.
Interests: IP6, myo-inositol, and other cyclitols: methods and determination; biological role; health-promoting activities; cancer; insulin resistance; pathological calcification
Inositol phosphates are a fascinating field of science. They belong to a huge and complex family of biomolecules, with important roles in cell regulation, signal transduction, energy transmission, and ion channels physiology, and serve as structural components of cell membranes. Inositol hexaphosphate (IP6 or InsP6 or phytic acid) and its parent compound myo-inositol are the most abundant, naturally occurring and widely distributed among plants and mammal’s tissues. Their discovery dates from the 1850s, when Hartig reported small round particles in various plant seeds, like potato starch grains (phytate). It was shown that these isolated particles were rich in phosphorous, calcium, and magnesium and were found only in plants, and the name “phytin” was created.
There are nine possible stereoisomers of inositol: cis-, epi-, allo-, myo-, muco-, neo-, (+)-chiro, (−)-chiro-, and scyllo-inositols, formed through the epimerization of its six hydroxyl groups. Although myo-inositol and IP6 have been extensively studied over the last three decades, the potential biological functions and possible medical applications of these other inositols and their phosphates have been recently considered.
IP6 and myo-inositol are active compounds of rice and other grains, with a broad spectrum of biological activities important in health and diseases. Their multiple health beneficial effects have been demonstrated in depression and anxiety disorders, neurodegenerative diseases, in inhibition of kidney stones formation and other pathological calcification, diabetes, metabolic syndrome, polycystic ovary syndrome, among many more. However, IP6 and myo-inositol have recently received much attention for their role in cancer prevention and treatment, shown in animals and humans. A consistent and reproducible anticancer activity has been demonstrated in different experimental models, targeting several key molecular targets, such as PI3K/Akt, MAPK, PKC, and NF-κB. Few clinical studies have indicated that IP6 alone or in combination with myo-inositol was able to enhance the anticancer effect of conventional therapy, control cancer metastases, and improve quality of life.
In this Special Issue a selection of research and review articles will cover a wide range of bioactivity of inositol phosphates from occurrence, chemistry, and methods for their determination in biological fluids, with numerous biological activities important in health and disease, with a focus on their most striking effect, the anticancer activity, that has been actively investigated during the last decades.
Dr. Ivana Vucenik
Manuscript Submission Information
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- Inositol hexaphosphate
- Depression and anxiety
- Neurodegenerative diseases
- Kidney stones
- Metabolic syndrome
- Polycystic ovary syndrome
- Anticancer activity