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Special Issue "Hyperpolarized Molecules for Applications in Chemistry and Biomedicine"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: 31 August 2020.

Special Issue Editor

Dr. Danila Barskiy
Website
Guest Editor
College of Chemistry & QB3, University of California at Berkeley, Berkeley, CA, United States
Interests: NMR; MRI; hyperpolarization; nuclear spin dynamics; chemical kinetics; catalysis

Special Issue Information

Dear Colleagues,

Nuclear magnetic resonance spectroscopy (NMR) and imaging (MRI) are among the most powerful analytical tools used to study chemical and biochemical transformations. However, one of the main drawbacks of NMR and MRI is their low sensitivity. Hyperpolarization techniques allow enhancing the NMR signals of various molecules by several orders of magnitude, making possible applications that were previously inaccessible, i.e., monitoring metabolism of small molecules in vivo.

Researchers working in the field of hyperpolarized NMR/MRI are invited to contribute original research papers or reviews to this Special Issue of Molecules, which will report on the chemistry and physics of hyperpolarization formation, improvements in the detection of hyperpolarized molecules, and applications of hyperpolarized NMR/MRI approaches in chemistry and biomedicine.

Dr. Danila Barskiy
Guest Editor

Discount Information:

We welcome you to submit abstracts first before 31 August 2020. We will provide different discounts to papers according to the abstract. Our Guest Editor will evaluate all qualified abstracts to be solicited. The following discounts will be awarded: two 50% discounts, three 30% discounts, and five 20% discounts.

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • hyperpolarization
  • nuclear magnetic resonance
  • magnetic resonance imaging
  • metabolism
  • cancer
  • bioprobes

Published Papers (1 paper)

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Research

Open AccessArticle
In Situ SABRE Hyperpolarization with Earth’s Field NMR Detection
Molecules 2019, 24(22), 4126; https://doi.org/10.3390/molecules24224126 - 14 Nov 2019
Abstract
Hyperpolarization methods, which increase the sensitivity of nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI), have the potential to expand the range of applications of these powerful analytical techniques and to enable the use of smaller and cheaper devices. The signal amplification [...] Read more.
Hyperpolarization methods, which increase the sensitivity of nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI), have the potential to expand the range of applications of these powerful analytical techniques and to enable the use of smaller and cheaper devices. The signal amplification by reversible exchange (SABRE) method is of particular interest because it is relatively low-cost, straight-forward to implement, produces high-levels of renewable signal enhancement, and can be interfaced with low-cost and portable NMR detectors. In this work, we demonstrate an in situ approach to SABRE hyperpolarization that can be achieved using a simple, commercially-available Earth’s field NMR detector to provide 1H polarization levels of up to 3.3%. This corresponds to a signal enhancement over the Earth’s magnetic field by a factor of ε > 2 × 108. The key benefit of our approach is that it can be used to directly probe the polarization transfer process at the heart of the SABRE technique. In particular, we demonstrate the use of in situ hyperpolarization to observe the activation of the SABRE catalyst, the build-up of signal in the polarization transfer field (PTF), the dependence of the hyperpolarization level on the strength of the PTF, and the rate of decay of the hyperpolarization in the ultra-low-field regime. Full article
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