Special Issue "Glycans in Design and Synthesis of Biofunctional Materials"
Deadline for manuscript submissions: closed (15 December 2019).
Interests: carbohydrates; glycosaminoglycans; self-assembly; extracellular matrix
Carbohydrates are the most abundant biomolecules on our planet, and are the main structural components and a source of energy in various biological systems. Their role, however, goes far beyond these simple functions: carbohydrates are involved in a plethora of recognition events triggering specific pathways and defining an organism's diversity. The functional decoration of biomolecules (e.g., proteins and lipids) with carbohydrates is known as glycosylation and it is a common post-translational modification used by nature to create bioscripts and/or to diversify the repertoire of the functionalised biomolecules beyond the bioactivities coded by their amino acids or nucleotide sequences. These diverse glycan roles have been used in different biomimicking approaches for the development of biomaterials. The success of these approaches is often compromised by the glycan modification needed for the subsequent processing, e.g., immobilisation or gelation. Glycan functionalisation is challenging because of the many functional groups that have to be protected in order to get one specific group to react. Modification can also compromise the glycans’ bioactivity as it is based on multivalent cooperative interactions involving different functional groups. The material design must also consider a physiologically relevant milieu, usually aqueous, where the molecular recognition can be impeded by the multiple hydrogen bonds simultaneously formed with the habitat. This Special Issue aims to present different approaches that use glycans or their derivatives with preserved bioactivity for the development of functional materials with molecular recognition.
Dr. Iva Pashkuleva
Manuscript Submission Information
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- glycan-protein interactions
- bioactive surfaces
- multivalent interactions