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Molecules
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Stationary Phases in Separation Techniques
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Stationary Phases in Separation Techniques

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 11940

Special Issue Editors

Dr. Magdalena Wojciak-Kosior

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Guest Editor
Department of Analytical Chemistry, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland
Interests: secondary plant metabolites; plant extracts; biological activity of natural compounds; polyphenols; chromatography
Special Issues, Collections and Topics in MDPI journals
Dr. Ireneusz Sowa

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Guest Editor
Department of Analytical Chemistry, Faculty of Pharmacy with Medical, Analytics Division, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Despite the considerable advances that have been made in direct analysis methods, separation techniques remain most frequently applied to samples with complex matrices. They have been used to analyse plant, medical, pharmaceutical, nutritional or environmental samples, especially at low levels of target compounds. The most important element of any separation system is the stationary phase, as the separation process takes place at this site. The development of new materials remains an important trend in analytical chemistry due to the diverse nature of analytes, which leads to different analytical problems. Efforts have been made to develop new materials with enhanced stability, selectivity towards target compounds, and reusability.

This Special Issue will be devoted to stationary phases used, e.g., in extraction and chromatographic techniques. Articles on the synthesis and the investigation of the properties of new stationary phases will be especially appreciated. In addition, we also encourage you to send papers that present interesting applications of the currently available stationary phases.

We would be delighted if you could respond to confirm your contribution and send us the proposed title by 30 September 2020 to assist with planning the project.

Prof. Ireneusz Sowa
Prof. Magdalena Wójciak-Kosior
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stationary phases in chromatography (e.g., HPLC, GC, TLC)
  • adsorbents in separation techniques (e.g., SPE, MSPD, DSPE)
  • sample preparation
  • sample pretreatment
  • analysis of plant/food/environment and biomedical samples
  • analysis of pharmaceuticals
  • miniaturization
  • green analytical chemistry

Published Papers (4 papers)

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Research

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16 pages, 1851 KiB  
Article
Comparison of the Retention and Separation Selectivity of Aromatic Hydrocarbons with Polar Groups in RP-HPLC Systems with Different Stationary Phases and Eluents
by Anna Klimek-Turek, Beata Misiołek and Tadeusz H. Dzido
Molecules 2020, 25(21), 5070; https://doi.org/10.3390/molecules25215070 - 01 Nov 2020
Viewed by 1812
Abstract
In this manuscript, the retention of aromatic hydrocarbons with polar groups has been compared for systems with various nonpolar columns of the types from C3 to C18 and different mobile phases composed of methanol, acetonitrile, or tetrahydrofuran as modifiers. The selectivity separation of [...] Read more.
In this manuscript, the retention of aromatic hydrocarbons with polar groups has been compared for systems with various nonpolar columns of the types from C3 to C18 and different mobile phases composed of methanol, acetonitrile, or tetrahydrofuran as modifiers. The selectivity separation of the solutes in systems with different adsorbents, when one eluent modifier is swapped by another, has been explained, taking into account molecular interactions of the solutes with components of the stationary phase region (i.e., extracted modifier depending on the chain length of the stationary phase). Full article
(This article belongs to the Special Issue Stationary Phases in Separation Techniques)
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9 pages, 1320 KiB  
Communication
Affinity of Antifungal Isoxazolo[3,4-b]pyridine-3(1H)-Ones to Phospholipids in Immobilized Artificial Membrane (IAM) Chromatography
by Krzesimir Ciura, Joanna Fedorowicz, Petar Žuvela, Mario Lovrić, Hanna Kapica, Paweł Baranowski, Wiesław Sawicki, Ming Wah Wong and Jarosław Sączewski
Molecules 2020, 25(20), 4835; https://doi.org/10.3390/molecules25204835 - 20 Oct 2020
Cited by 8 | Viewed by 2067
Abstract
Currently, rapid evaluation of the physicochemical parameters of drug candidates, such as lipophilicity, is in high demand owing to it enabling the approximation of the processes of absorption, distribution, metabolism, and elimination. Although the lipophilicity of drug candidates is determined using the shake [...] Read more.
Currently, rapid evaluation of the physicochemical parameters of drug candidates, such as lipophilicity, is in high demand owing to it enabling the approximation of the processes of absorption, distribution, metabolism, and elimination. Although the lipophilicity of drug candidates is determined using the shake flash method (n-octanol/water system) or reversed phase liquid chromatography (RP-LC), more biosimilar alternatives to classical lipophilicity measurement are currently available. One of the alternatives is immobilized artificial membrane (IAM) chromatography. The present study is a continuation of our research focused on physiochemical characterization of biologically active derivatives of isoxazolo[3,4-b]pyridine-3(1H)-ones. The main goal of this study was to assess the affinity of isoxazolones to phospholipids using IAM chromatography and compare it with the lipophilicity parameters established by reversed phase chromatography. Quantitative structure–retention relationship (QSRR) modeling of IAM retention using differential evolution coupled with partial least squares (DE-PLS) regression was performed. The results indicate that in the studied group of structurally related isoxazolone derivatives, discrepancies occur between the retention under IAM and RP-LC conditions. Although some correlation between these two chromatographic methods can be found, lipophilicity does not fully explain the affinities of the investigated molecules to phospholipids. QSRR analysis also shows common factors that contribute to retention under IAM and RP-LC conditions. In this context, the significant influences of WHIM and GETAWAY descriptors in all the obtained models should be highlighted. Full article
(This article belongs to the Special Issue Stationary Phases in Separation Techniques)
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Review

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22 pages, 371 KiB  
Review
Silica-Based Monolithic Columns as a Tool in HPLC—An Overview of Application in Analysis of Active Compounds in Biological Samples
by Michał Staniak, Magdalena Wójciak, Ireneusz Sowa, Katarzyna Tyszczuk-Rotko, Maciej Strzemski, Sławomir Dresler and Wojciech Myśliński
Molecules 2020, 25(14), 3149; https://doi.org/10.3390/molecules25143149 - 09 Jul 2020
Cited by 9 | Viewed by 2882
Abstract
Monolithic fillings used in chromatography are of great interest among scientists since the first reports of their synthesis and use were published. In the 20 years since silica-based monolithic columns were introduced into the commercial market, numerous papers describing their chromatographical properties and [...] Read more.
Monolithic fillings used in chromatography are of great interest among scientists since the first reports of their synthesis and use were published. In the 20 years since silica-based monolithic columns were introduced into the commercial market, numerous papers describing their chromatographical properties and utility in various branches of industry and scientific investigations were presented. This review is focused on possible applications of commercially available silica-based HPLC monolithic columns in the analysis of biological samples. Full article
(This article belongs to the Special Issue Stationary Phases in Separation Techniques)
29 pages, 12159 KiB  
Review
Various Strategies in Post-Polymerization Functionalization of Organic Polymer-Based Monoliths Used in Liquid Phase Separation Techniques
by Sarah Alharthi and Ziad El Rassi
Molecules 2020, 25(6), 1323; https://doi.org/10.3390/molecules25061323 - 13 Mar 2020
Cited by 10 | Viewed by 4685
Abstract
This review article is aimed at summarizing the various strategies that have been developed so far for post-polymerization functionalization (PPF) of organic polymer-based monoliths used in liquid phase separation techniques, namely HPLC at all scales and capillary electrochromatography (CEC). The reader will find [...] Read more.
This review article is aimed at summarizing the various strategies that have been developed so far for post-polymerization functionalization (PPF) of organic polymer-based monoliths used in liquid phase separation techniques, namely HPLC at all scales and capillary electrochromatography (CEC). The reader will find the organic reactions performed on monolithic columns for grafting the chromatographic ligands needed for solving the separation problems on hand. This process involves therefore the fabrication of template monoliths that carry reactive functional groups to which chromatographic ligands can be covalently attached in a post-polymerization kind of approach. That is, the template monolith that has been optimized in terms of pore structure and other morphology can be readily modified and tailor made on column to fit a particular separation. The review article will not only cover the various strategies developed so far but also describe their separation applications. To the best of our knowledge, this review article will be the first of its kind. Full article
(This article belongs to the Special Issue Stationary Phases in Separation Techniques)
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