Aziridine Chemistry
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 10000
Special Issue Editor
Special Issue Information
Dear Colleagues,
Aziridine is a nitrogen-containing three-membered ring with a similar ring-strained energy as other three-membered ring compounds, including cyclopropane and oxirane. Its high ring-strained energy supplies various nitrogen-containing compounds. Many synthetic organic chemists explore “aziridine chemistry”, including synthesis of valuable aziridines and their utilization as key synthetic intermediates. However, aziridine has been studied relatively less extensively compared to oxirane (epoxide) because the preparation and utilization of aziridine are relatively arduous. According to Scopus®, the number of publications with the search word “aziridine” is 6925 from 1948 to October 1 of 2020, that is, less than 13% compared to the numbers with “oxirane” (or epoxide). The stability and chemistry of aziridines including ring-opening by nucleophiles are dependent on the substituents at the ring nitrogen, whether they are electron-withdrawing or -donating. Aziridines are bifurcated into “activated”, bearing electron-withdrawing substituents at the ring nitrogen, and “non-activated” with electron-donating substituents. Successful tailing of aziridines with various substituents would warrant a streamlined synthesis of valuable and biologically active amines and heterocycles by regio- and stereoselective aziridine-ring openings and ring transformations.
This Special Issue named “Aziridine Chemistry” includes communications in the form of original research and review articles covering the synthesis and utilization of aziridine as starting materials and synthetic intermediates. I therefore kindly encourage submission of your work within the scope of “Aziridine Chemistry” in this Special Issue 133 years after Gabriel’s 1888 discovery of aziridine. In addition, authors considering the submission of a review are kindly asked to provide in advance to the guest editor a brief outline of the subject matter of their work.
Prof. Hyun-Joon Ha
Guest Editor
Manuscript Submission Information
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Keywords
- aziridine
- heterocycles
- synthetic methodology
- amines
- synthesis
- stereo-selectivity
- regioselectivity
