Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.6
4.6
Journals
Molecules
Special Issues
Marine Natural Products: Isolations, Structures and Bioactivities
molecules-logo
Submit to Molecules Review for Molecules Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Marine Natural Products: Isolations, Structures and Bioactivities

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 3779

Special Issue Editor

Dr. Pinglin Li

E-Mail Website
Guest Editor
School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Interests: configuration; chiral; chromatography; molecular computerize
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural medicinal chemistry is a traditional discipline which aims to apply the principles of spectroscopy and medicine, explore natural resources, discover functional molecules that can effectively solve the problems of human survival and development, and reveal the general laws of natural evolution and development from the perspective of functional molecules. It is a discipline full of natural mysteries, enjoying the exploration of winding paths and scientific thinking of transforming feathers. Low-quality (MW<1000) functional molecules are the main research objects of natural medicinal chemistry, with extremely rich structural diversity and functional specificity, containing profound scientific problems and broad research and development prospects. The ocean contains enormous amounts of biological resources, and in-depth research on these resources is important for sustainable human development in the future. Coral reef ecosystems are extremely rich in species diversity and habitat particularity, especially reef-dwelling invertebrate sponges and corals. Like other organisms, their chemical defense phenomenon based on 

functional molecules provides important scientific enlightenment for the research and development of modern marine natural drugs. The deep exploration of this resource constitutes an important scientific axis in the multidimensional research on marine drugs. Its core is the exploration of specific chemical structural molecules, following the principle of unity in natural addition.

This Special Issue aims to publish high-quality research on various structures and diverse bioactivity.

Dr. Pinglin Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • structure identification
  • configuration study
  • flexible molecular
  • bioactivity essay method

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

15 pages, 2087 KiB  
Article
Cytotoxic and Anti-HSV-1 Effects of Caulerpin Derivatives
by Gisely Maria Freire Abílio, Cicera Janaine Camilo, Henrique Douglas Melo Coutinho, José Galberto Martins da Costa, Lindomar José Pena, Abelardo Silva-Júnior, Yuri Mangueira do Nascimento, José Maria Barbosa-Filho, Bárbara Viviana de Oliveira Santos and Kristerson Reinaldo de Luna Freire
Molecules 2024, 29(16), 3859; https://doi.org/10.3390/molecules29163859 - 15 Aug 2024
Cited by 3 | Viewed by 1234
Abstract
Marine organisms represent a potential source of secondary metabolites with various therapeutic properties. However, the pharmaceutical industry still needs to explore the algological resource. The species Caulerpa lamouroux Forssk presents confirmed biological activities associated with its major compound caulerpin, such as antinociceptive, spasmolytic, [...] Read more.
Marine organisms represent a potential source of secondary metabolites with various therapeutic properties. However, the pharmaceutical industry still needs to explore the algological resource. The species Caulerpa lamouroux Forssk presents confirmed biological activities associated with its major compound caulerpin, such as antinociceptive, spasmolytic, antiviral, antimicrobial, insecticidal, and cytotoxic. Considering that caulerpin is still limited, such as low solubility or chemical instability, it was subjected to a structural modifications test to establish which molecular regions could accept structural modification and to elucidate the cytotoxic bioactive structure in Vero cells (African green monkey kidney cells, Cercopithecus aethiops; ATCC, Manassas, VA, USA) and antiviral to Herpes simplex virus type 1. Substitution reactions in the N-indolic position with mono- and di-substituted alkyl, benzyl, allyl, propargyl, and ethyl acetate groups were performed, in addition to conversion to their acidic derivatives. The obtained analogs were submitted to cytotoxicity and antiviral activity screening against Herpes simplex virus type 1 by the tetrazolium microculture method. From the semi-synthesis, 14 analogs were obtained, and 12 are new. The cytotoxicity assay showed that caulerpin acid and N-ethyl-substituted acid presented cytotoxic concentrations referring to 50% of the maximum effect of 1035.0 µM and 1004.0 µM, respectively, values significantly higher than caulerpin. The antiviral screening of the analogs revealed that the N-substituted acids with methyl and ethyl groups inhibited Herpes simplex virus type 1-induced cytotoxicity by levels similar to the positive control acyclovir. Full article
(This article belongs to the Special Issue Marine Natural Products: Isolations, Structures and Bioactivities)
►▼ Show Figures

Graphical abstract

16 pages, 6431 KiB  
Article
Theoretical and Experimental Studies on the Evidence of 1,3-β-Glucan in Marennine of Haslea ostrearia
by Muhammad Yusuf, Umi Baroroh, Rina Fajri Nuwarda, Fiddy Semba Prasetiya, Safri Ishmayana, Mia Tria Novianti, Taufik Ramdani Tohari, Ari Hardianto, Toto Subroto, Jean-Luc Mouget and Pamela Pasetto
Molecules 2023, 28(15), 5625; https://doi.org/10.3390/molecules28155625 - 25 Jul 2023
Cited by 5 | Viewed by 2046
Abstract
Marennine, a blue pigment produced by the blue diatom Haslea ostrearia, is known to have some biological activities. This pigment is responsible for the greening of oysters on the West Coast of France. Other new species of blue diatom, H. karadagensis, [...] Read more.
Marennine, a blue pigment produced by the blue diatom Haslea ostrearia, is known to have some biological activities. This pigment is responsible for the greening of oysters on the West Coast of France. Other new species of blue diatom, H. karadagensis, H. silbo sp. inedit., H. provincialis sp. inedit, and H. nusantara, also produce marennine-like pigments with similar biological activities. Aside from being a potential source of natural blue pigments, H. ostrearia-like diatoms present a commercial potential for the aquaculture, food, cosmetics, and health industries. Unfortunately, for a hundred years, the exact molecular structure of this bioactive compound has remained a mystery. A lot of hypotheses regarding the chemical structure of marennine have been proposed. The recent discovery of this structure revealed that it is a macromolecule, mainly carbohydrates, with a complex composition. In this study, some glycoside hydrolases were used to digest marennine, and the products were further analyzed using nuclear magnetic resonance (NMR) and mass spectroscopy (MS). The reducing sugar assay showed that marennine was hydrolyzed only by endo-1,3-β-glucanase. Further insight into the structure of marennine was provided by the spectrum of 1H NMR, MS, a colorimetric assay, and a computational study, which suggest that the chemical structure of marennine contains 1,3-β-glucan. Full article
(This article belongs to the Special Issue Marine Natural Products: Isolations, Structures and Bioactivities)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop