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Novel Functional Biomaterials for Drug Delivery

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 2139

Special Issue Editors

School of Medicine, Shanghai Jiao Tong University, 197 Ruijin 2nd Road, Shanghai 200025, China
Interests: biomaterial; drug delivery system; hydrogel; self-assembly; phospholipid-mimic
School of Medicine, Shanghai Jiao Tong University, 197 Ruijin 2nd Road, Shanghai, 200025, China
Interests: biomaterials; tissue regeneration; drug delivery; electrospun; nanofibers
Special Issues, Collections and Topics in MDPI journals
School of Medicine, Shanghai Jiao Tong University, 197 Ruijin 2nd Road, Shanghai 200025, China
Interests: biomaterial; phosphorus dendrimer; drug delivery system; regeneration; gene carrier
Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
Interests: drug delivery system; self-assembly; liposome; phospholipid; gene carrier

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Guest Editor
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Interests: photosensitive hydrogel; hydrogel microsphere; hydrogel patch; oral drug delivery and tissue engineering

Special Issue Information

Dear Colleagues,

Since the concept of drug carriers was proposed, various forms of drug delivery systems (DDSs) have been reported in recent decades, especially based on nanotechnology. It is widely accepted that DDS technology is crucial to the therapeutic strategy of almost all sorts of diseases. In this area, functional material design is one of the most common pointcuts for developing novel DDSs. On one hand, biomaterials with nano- or microscale organizations could be applied as carriers to encapsulate different cargos for controllable delivery or release, such as nanostructured lipid carriers (NLC). On the other hand, chemical derivatization could directly change the physicochemical and pharmaceutical properties of molecules. The formulated prodrugs could demonstrate meliorative stability, solubility, specificity, or even self-assembly capacity. Undoubtedly, the further design of these chemical structures could provide additional contrivable functions for better efficacies.

This Special Issue focuses on the novel DDS designs based on functional biomaterials as well as the latest advances in basic or applied research. Any works around this topic are welcomed to be submitted to this Special Issue. We accept all sorts of articles, including but not limited to reviews, original research articles, and communications.

Dr. Yawei Du
Dr. Juan Wang
Dr. Liang Chen
Dr. Wei He
Dr. Zhengwei Cai
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • drug delivery system
  • prodrug
  • nanoparticle
  • liposome
  • micelle
  • controlled release
  • stimuli response
  • self-assembly

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Published Papers (1 paper)

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Research

19 pages, 6023 KiB  
Article
L-Cysteine-Modified Transfersomes for Enhanced Epidermal Delivery of Podophyllotoxin
by Jiangxiu Niu, Ming Yuan, Jingjing Chen, Liye Wang, Yueheng Qi, Kaiyue Bai, Yanli Fan and Panpan Gao
Molecules 2023, 28(15), 5712; https://doi.org/10.3390/molecules28155712 - 28 Jul 2023
Cited by 3 | Viewed by 1809
Abstract
The purpose of this study was to evaluate L-cysteine-modified transfersomes as the topical carrier for enhanced epidermal delivery of podophyllotoxin (POD). L-cysteine-deoxycholic acid (LC-DCA) conjugate was synthesized via an amidation reaction. POD-loaded L-cysteine-modified transfersomes (POD-LCTs) were prepared via a thin membrane dispersion method [...] Read more.
The purpose of this study was to evaluate L-cysteine-modified transfersomes as the topical carrier for enhanced epidermal delivery of podophyllotoxin (POD). L-cysteine-deoxycholic acid (LC-DCA) conjugate was synthesized via an amidation reaction. POD-loaded L-cysteine-modified transfersomes (POD-LCTs) were prepared via a thin membrane dispersion method and characterized for their particle size, zeta potential, morphology, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and in vitro release. Subsequently, in vitro skin permeation and retention, fluorescence distribution in the skin, hematoxylin–eosin staining and in vivo skin irritation were studied. The POD-LCTs formed spherical shapes with a particle size of 172.5 ± 67.2 nm and a zeta potential of −31.3 ± 6.7 mV. Compared with the POD-Ts, the POD-LCTs provided significantly lower drug penetration through the porcine ear skin and significantly increased the skin retention (p < 0.05). Meaningfully, unlike the extensive distribution of the POD-loaded transfersomes (POD-Ts) throughout the skin tissue, the POD-LCTs were mainly located in the epidermis. Moreover, the POD-LCTs did not induce skin irritation. Therefore, the POD-LCTs provided an enhanced epidermal delivery and might be a promising carrier for the topical delivery of POD. Full article
(This article belongs to the Special Issue Novel Functional Biomaterials for Drug Delivery)
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