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Cyclodextrins: From Fundamental Studies to Applications

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A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 5970

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Special Issue Editor

Prof. Dr. Israel V. M. V. Enoch

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Guest Editor

Centre for Nanoscience and Genomics, Karunya Institute of Technology and Sciences (Deemed University), Coimbatore 641114, Tamil Nadu, India
Interests: cyclodextrin; anticancer activity; carbohydrate polymer; host : guest complex; magnetic nanoparticles; drug delivery; G-quadruplex binding fluorescence spectroscopy

Special Issue Information

Dear Colleagues,

Molecules intends to publish a Special Issue entitled ‘Cyclodextrins: From Fundamental Studies to Applications’. The fundamental studies include the synthesis of cyclodextrin complexes and modified cyclodextrins and the characterization of them employing spectroscopy, crystallography, and imaging techniques. The applications cover a wide spectrum of areas, i.e., from pharmaceutical, agricultural, or food to materials, environmental, or energy applications. This Special Issue will include reviews and original scientific papers that are focused on the advancement of knowledge in the field and open up new avenues in cyclodextrin chemistry and the allied sciences. Manuscripts are invited from (but not limited to) the following specific areas:

Structural characterization of cyclodextrins using advanced spectroscopic and imaging methods;
Novel cyclodextrin pharmaceutical and cosmetic formulations;
Drug delivery including native and modified cyclodextrins or cyclodextrin-based polymers;
Novel cyclodextrin derivatives applied to agriculture, food technology, and nutraceuticals;
Biologically active cyclodextrin derivatives;
Cyclodextrins in energy and environmental applications;
Nanoparticulate systems of cyclodextrins and surface modification of nanoparticles using cyclodextrins.

Prof. Dr. Israel V. M. V. Enoch
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

cyclodextrin
drug delivery
pharmaceutical analysis
spectroscopic characterization
cyclodextrin in agriculture
cyclodextrin in food
host : guest complex
in vitro/in vivo studies
modified cyclodextrin
inclusion complex
spectral characterization
food processing
cyclodextrin polymer
nanoparticles

Published Papers (4 papers)

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Research

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17 pages, 5352 KiB

Open AccessArticle

Solubility and Pharmacokinetic Profile Improvement of Griseofulvin through Supercritical Carbon Dioxide-Assisted Complexation with HP-γ-Cyclodextrin

by Yili Ding, Wutong Cui, Zhiyuan Zhang, Yanzhi Ma, Charles Ding, Yikai Lin and Zhe Xu

Molecules 2023, 28(21), 7360; https://doi.org/10.3390/molecules28217360 - 31 Oct 2023

Cited by 2 | Viewed by 1171

Abstract

Since griseofulvin was marketed as a non-polyene antifungal antibiotic drug in 1958, its poor water solubility has been an issue for its wide applications, and over the last sixty years, many attempts have been made to increase its water solubility; however, a significant result has yet to be achieved. Through supercritical carbon dioxide-assisted cyclodextrin complexation with the addition of a trace amount of water-soluble polymer surfactant, the griseofulvin inclusion complex with HP-γ-cyclodextrin was prepared and confirmed. The 1:2 ratio of griseofulvin and HP-γ-cyclodextrin in the complex was determined based on its NMR study. After complexation with HP-γ-cyclodextrin, griseofulvin’s water solubility was increased 477 times compared with that of griseofulvin alone, which is the best result thus far. The complex showed 90% of griseofulvin release in vitro in 10 min, in an in vivo dog pharmacokinetic study; the C_max was increased from 0.52 µg/mL to 0.72 µg/mL, AUC_0–12 was increased from 1.55 μg·h/mL to 2.75 μg·h/mL, the clearance was changed from 51.78 L/kg/h to 24.16 L/kg/h, and the half-life time was changed from 0.81 h to 1.56 h, indicating the obtained griseofulvin complex can be a more effective drug than griseofulvin alone. Full article

(This article belongs to the Special Issue Cyclodextrins: From Fundamental Studies to Applications)

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20 pages, 6868 KiB

Open AccessArticle

The Use of Cyclodextrin Inclusion Complexes to Increase the Solubility and Pharmacokinetic Profile of Albendazole

by Yili Ding, Zhiyuan Zhang, Charles Ding, Shufeng Xu and Zhe Xu

Molecules 2023, 28(21), 7295; https://doi.org/10.3390/molecules28217295 - 27 Oct 2023

Cited by 2 | Viewed by 1199

Abstract

Albendazole is the preferred deworming drug and has strong insecticidal effects on human and animal helminth parasites, showing remarkable activity against hepatocellular carcinoma and colorectal cancer cells. However, it is classified as being in class II in the Biopharmaceutics Classification System due to its poor water solubility (0.2 mg/L) and high permeability, which make the clinical application of albendazole impractical. Through complexation with methyl-β-cyclodextrin, as the best result so far, albendazole’s water solubility was increased by 150,000 times, and albendazole could be 90% released during the first 10 min. In an in vivo pharmacokinetic study, the C_max and T_max of the active metabolized sulfoxide were changed from 2.81 µg/mL at 3 h to 10.2 µg/mL at 6 h and the AUC_0–48 was increased from 50.72 h⁎μg/mL to 119.95 h⁎μg/mL, indicating that the inclusion complex obtained can be used as a new oral therapeutic anti-anthelmintic and anti-tumor agent formulation. Full article

(This article belongs to the Special Issue Cyclodextrins: From Fundamental Studies to Applications)

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Graphical abstract

20 pages, 5703 KiB

Open AccessArticle

Quaternary Ammonium Groups Modified Magnetic Cyclodextrin Polymers for Highly Efficient Dye Removal and Sterilization in Water Purification

by Bingjie Liu, Shuoxuan Wang, He Wang, Yong Wang, Yin Xiao and Yue Cheng

Molecules 2023, 28(1), 167; https://doi.org/10.3390/molecules28010167 - 25 Dec 2022

Cited by 3 | Viewed by 1505

Abstract

Water recovery is a significant proposition for human survival and sustainable development, and we never stop searching for more efficient, easy-operating, low-cost and environmentally friendly methods to decontaminate water bodies. Herein, we combined the advantages of β-cyclodextrin (β-CD), magnetite nanoparticles (MNs), and two kinds of quaternary ammonium salts to synthesize two porous quaternary ammonium groups capped magnetic β-CD polymers (QMCDP1 and QMCDP2) to remove organic pollutants and eradicate pathogenic microorganisms effectively through a single implementation. In this setting, β-CD polymer (CDP) was utilized as the porous substrate material, while MNs endowed the materials with excellent magnetism enhancing recyclability in practical application scenarios, and the grafting of quaternary ammonium groups was beneficial for the adsorption of anionic dyes and sterilization. Both QMCDPs outperformed uncapped MCDPs in their adsorption ability of anionic pollutants, using methyl blue (MB) and orange G (OG) as model dyes. Additionally, QMCDP2, which was modified with longer alkyl chains than QMCDP1, exhibits superior bactericidal efficacy with a 99.47% removal rate for Staphylococcus aureus. Accordingly, this study provides some insights into designing a well-performed and easily recyclable adsorbent for simultaneous sterilization and adsorption of organic contaminants in wastewater. Full article

(This article belongs to the Special Issue Cyclodextrins: From Fundamental Studies to Applications)

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Review

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33 pages, 1776 KiB

Open AccessFeature PaperReview

Review of Applications of Cyclodextrins as Taste-Masking Excipients for Pharmaceutical Purposes

by Lena Adamkiewicz and Łukasz Szeleszczuk

Molecules 2023, 28(19), 6964; https://doi.org/10.3390/molecules28196964 - 7 Oct 2023

Cited by 4 | Viewed by 1607

Abstract

It is widely recognized that many active pharmaceutical ingredients (APIs) have a disagreeable taste that affects patient acceptability, particularly in children. Consequently, developing dosage forms with a masked taste has attracted a lot of interest. The application of cyclodextrins as pharmaceutical excipients is highly appreciated and well established, including their roles as drug delivery systems, solubilizers and absorption promoters, agents that improve drug stability, or even APIs. The first work describing the application of the taste-masking properties of CDs as pharmaceutical excipients was published in 2001. Since then, numerous studies have shown that these cyclic oligosaccharides can be effectively used for such purposes. Therefore, the aim of this review is to provide insight into studies in this area. To achieve this aim, a systematic evaluation was conducted, which resulted in the selection of 67 works representing both successful and unsuccessful works describing the application of CDs as taste-masking excipients. Particular attention has been given to the methods of evaluation of the taste-masking properties and the factors affecting the outcomes, such as the choice of the proper cyclodextrin or guest–host molar ratio. The conclusions of this review reveal that the application of CDs is not straightforward; nevertheless, this solution can be an effective, safe, and inexpensive method of taste masking for pharmaceutical purposes. Full article

(This article belongs to the Special Issue Cyclodextrins: From Fundamental Studies to Applications)

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