Nucleoside and Nucleotide Analogues: Chemical Synthesis and Applications
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 8060
Special Issue Editors
Interests: nucleic acids; phosphodiesters; reaction mechanisms; catalysis
Interests: nucleic acids; oligonucleotides and their conjugates; nucleic acid-based nanoparticles; liquid phase oligonucleotide synthesis
Interests: organometallic nucleoside analogues; metal-mediated base pairing; base filling; RNA cleavage
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nucleoside and nucleotide analogs have been intensively studied over the last decades. They have found various applications in chemical and biochemical research, and medicine. The development of nucleoside-based antivirals and pro-drugs started with the AIDS epidemic, and their importance was further emphasized by the recent COVID-19 pandemic. Currently, the majority of research on nucleoside and nucleotide analogs describe the synthesis of potential antiviral agents, with SARS-CoV being the prevailing target.
The applications of nucleoside and nucleotide analogs are, however, much more diverse. Mechanistic studies with analogues are used to obtain information on basic reaction mechanisms and interactions of nucleic acids. A more recent application is the use of fluorescent analogues in detection technology.
While we do not want to exclude any approach in this Special Issue on nucleoside and nucleotide analogs, we would like to concentrate on chemical applications, such as studies on reaction mechanisms, interactions, recognition, and development of detection methods, as well as novel synthetic methods.
Dr. Satu Mikkola
Prof. Dr. Pasi Virta
Dr. Tuomas Lönnberg
Guest Editors
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Keywords
- nucleoside analogues
- nucleic acids
- interactions
- detection
- synthesis
- reaction mechanism
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