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Special Issue "Transcription Factors as Therapeutic Targets II"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (1 December 2019).

Special Issue Editor

Dr. Takaomi Sanda
E-Mail Website
Guest Editor
Cancer Science Institute of Singapore, National University of Singapore/Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
Interests: transcription; transcription factor; enhancer; core regulatory circuit; stem cells; hematopoiesis; acute leukemia; T-cell acute lymphoblastic leukemia; oncogene; TAL1
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Deregulation of transcription factor genes are frequently observed in various human diseases.  Understanding the molecular pathogenesis as well as the development of therapeutic approaches are crucial to further advance the treatment outcome.  Although the feasibility of transcription factors as therapeutic targets has long been realized, the development of drugs is still very challenging due to several pharmacological and biological reasons.  Therefore, an improved knowledge is necessary to make transcription factors “actionable”. The second edition of this Special Issue aims to provide a forum for the dissemination of the latest information on new approaches and methods targeting transcription factors, and with methods of testing their success in cancer or other human diseases.

Dr. Takaomi Sanda
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Transcription
  • Transcription factor
  • Enhancer
  • Epigenetics
  • Chromatin
  • Small-molecules
  • Cancer
  • Immunological diseases
  • Infectious diseases
  • Neuronal diseases

Published Papers (1 paper)

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Review

Open AccessReview
P-TEFb as A Promising Therapeutic Target
Molecules 2020, 25(4), 838; https://doi.org/10.3390/molecules25040838 (registering DOI) - 14 Feb 2020
Abstract
The positive transcription elongation factor b (P-TEFb) was first identified as a general factor that stimulates transcription elongation by RNA polymerase II (RNAPII), but soon afterwards it turned out to be an essential cellular co-factor of human immunodeficiency virus (HIV) transcription mediated by [...] Read more.
The positive transcription elongation factor b (P-TEFb) was first identified as a general factor that stimulates transcription elongation by RNA polymerase II (RNAPII), but soon afterwards it turned out to be an essential cellular co-factor of human immunodeficiency virus (HIV) transcription mediated by viral Tat proteins. Studies on the mechanisms of Tat-dependent HIV transcription have led to radical advances in our knowledge regarding the mechanism of eukaryotic transcription, including the discoveries that P-TEFb-mediated elongation control of cellular transcription is a main regulatory step of gene expression in eukaryotes, and deregulation of P-TEFb activity plays critical roles in many human diseases and conditions in addition to HIV/AIDS. P-TEFb is now recognized as an attractive and promising therapeutic target for inflammation/autoimmune diseases, cardiac hypertrophy, cancer, infectious diseases, etc. In this review article, I will summarize our knowledge about basic P-TEFb functions, the regulatory mechanism of P-TEFb-dependent transcription, P-TEFb’s involvement in biological processes and diseases, and current approaches to manipulating P-TEFb functions for the treatment of these diseases. Full article
(This article belongs to the Special Issue Transcription Factors as Therapeutic Targets II)
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