Special Issue "Plant-Derived Phenolic Compounds: From Molecular Mechanisms to Clinical Application"
Deadline for manuscript submissions: 28 February 2022.
Interests: drug delivery by nanoparticles in vitro; cell imaging; cellular models of inflammation; natural antioxidants for airway epithelium; chronic respiratory diseases
Interests: nose-to-brain delivery; applications of nanoparticles to drug delivery; Parkinson Disease; mucopenetration; mesenchymal stem cells; exosomes; airway diseases
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Plant-derived phenolic compounds, a large group of water-soluble metabolites, have protective roles against a variety of environmental stresses by scavenging free radicals during oxidative stress. Phenolic compounds vary from low molecular weight monomers to high molecular weight molecules and can be widely found in fruits, seeds, flowers, and leafs. The most important classes of phenolic compounds are flavonoids (i.e. catechin,epicatechin) quinones, stilbenes (i.e. resveratrol) and essential oils (i.e. thymol, carvacrol). Monomers of (+)-catechins and the isomer (−)-epicatechins polymerize to form condensed tannins called proanthocyanidins. Plant-derived phenolic compounds are considered as beneficial molecole for prevention and treatment of several diseases, since it has been shown that they have antioxidant, anticarcinogenic, cardioprotective, neuroprotective and anti-inflammatory properties. They have also proved effective as cardioprotective agents by inhibiting the LDL oxidation involved in the pathogenesis of atherosclerosis. Moreover, these active molecules have also evidenced efficacy in improving diabetic complications, such as neuropathy, retinopathy, or nephropathy. Plant-derived phenolic compounds have shown anticancer properties by slowing tumor development through inhibition of cell proliferation and induction of apoptosis. Phenolic compounds have been found to present strong antimicrobial agents, i.e. they provide antiadhesive actions against bacteria in urinary and dental infections. Finally, these compounds can increase migration of mesenchymal stem cells (MSCs) and enhance wound healing as well o control the functions and behavior of MSCs during immunomodulation. This Special Issue will contain contributions concerning different aspects of the use of phenolic plant-derived molecules for prevention and therapy of several diseases, in order to understand the mechanisms involved in their protective role, their bioavailability and their metabolism in human tissue. Moreover the use of different strategies for extraction, synthesis and delivery of these compounds,will be covered.
Prof. Dr. Stefano Castellani
Prof. Dr. Massimo Conese
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Phenolic compounds
- Oxidative stress
- Neurodegenerative diseases
- Cardiovascular diseases
- Mesenchymal stem cells
- Drug delivery