Special Issue "Polymer- and Lipid-Based Nanostructured Drug Delivery Systems for the Treatment of CNS Diseases: Recent Advances towards Clinical Application"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 31 May 2022.

Special Issue Editors

Prof. Dr. Giuseppe Trapani
E-Mail Website
Guest Editor
Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, 70125 Bari, Italy
Interests: brain targeting; nasal route; mucoadhesion; nanoparticles from renewable polymers; self-emulsifying lipid based drug delivery system; polymer-small molecule drug conjugates; cyclodextrins
Prof. Dr. Massimo Conese
E-Mail Website
Guest Editor
Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy
Interests: nose-to-brain delivery; applications of nanoparticles to drug delivery; Parkinson Disease; mucopenetration; mesenchymal stem cells; exosomes; airway diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Central Nervous System (CNS) is the most complex organ of the human body and, consequently, remarkable challenges must be tackled in the therapeutic treatment of neurological disorders, the most relevant being the crossing of the blood–brain barrier (BBB). At present, the treatment of CNS diseases is mainly symptomatic and there are no disease-modifying therapies for most of these disorders. In this context, it appears necessary not only to create more effective drugs but also to improve their corresponding delivery systems, particularly when complex drugs, including genes, antibodies, peptides, and proteins, as well as neurotrophic factors and stem cells for regenerative therapy, are to be administered. For this last purpose, in the last few decades several nanostructured biomaterials have been identified as tools for the preparation of advanced drug delivery systems that could potentially be useful for the treatment of neurological disorders. The main advantages of using such nanostructured biomaterials in the neurological field are the satisfactory overcoming of the BBB and their biocompatibility. Current research in this area is focused on slowing down disease progression to achieve the important goal of improving the quality of life of patients.

We are pleased to invite you to the Special Issue, which aims to serve as an overview of the current status, challenges, and recent advances in polymer- and lipid-based nanostructured formulations used for the treatment of neurological disorders.

For this Special Issue, in particular, we call to researchers involved in brain targeting, overcoming the BBB both by invasive (e.g., brain implants, BBB transient opening etc.), and non-invasive methods (prodrugs, intranasal administration route (i.e., nose-to-brain delivery) etc.) using different materials such as polymers and lipids from natural and renewable resources to participate. These raw materials can be used as such or in physical mixtures to provide advanced nanostructured drug delivery systems (DDS), including polymeric nanoparticles, micelles, hydrogels, and lipid nanocarriers (liposomes, solid lipid nanoparticles and nanostructured lipid carriers). Moreover, such nanostructured DDS can be appropriately functionalized with suitable molecules to provide particular properties such as brain targeting or stability in biological fluids. A relevant application of such functionalized nanostructured DDS is the treatment of the most aggressive brain tumors, which are characterized by an unfavourable prognosis. The mentioned materials can be also used as scaffolds for the transplantation of stem cells (neural, pluripotent, or mesenchymal) to induce and promote the regeneration of damaged neuronal cells in neurodegenerative diseases by secreting growth factors and the exosomes derived thereof. In this Special Issue, original research articles and reviews on the mentioned research areas are welcome, as well as scientific papers on the diagnostic applications of these nanosized DDS.

We look forward to receiving your contributions.

Prof. Dr. Giuseppe Trapani
Prof. Dr. Massimo Conese
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • neurodegenerative diseases
  • neurological diseases
  • brain tumors
  • brain targeting
  • nose-to-brain delivery
  • polymers from natural and renewable resources
  • polymer/lipid nanoparticles
  • neurotrophic factors
  • stem cells
  • exosomes

Published Papers

This special issue is now open for submission.
Back to TopTop