E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Special Issue "Medicinal Plants and Diabetes"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (30 July 2018)

Special Issue Editor

Guest Editor
Prof. Oluwafemi Oguntibeju

Phytomedicine and Diabetes Research Group, Oxidative Stress Research Centre, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7535, South Africa
Website | E-Mail
Interests: diabetes; diabetic complications; oxidative stress; medicinal plants; obesity; diabetes-related cardiovascular disease

Special Issue Information

Dear Colleagues,

Diabetes mellitus (DM) is a major public health burden, increasing dramatically with 25% of global population believed to be diabetic. It has been predicted that over 552 million people will be diabetic with the projection that 1 in 10 non-diabetic adults will become diabetic by 2030. Plants with medicinal values are known to play significant role globally particularly in African and Asian regions in the management and treatment of various chronic diseases including diabetes. In African and Asian regions, due to low socio-economic patterns, about 80% of these populations predominantly depend on plant products as their primary healthcare sources. The interest in medicinal plants has grown possibly due to their availability, accessibility and the general belief that they demonstrate minimum side effects. The relative cost of pharmacological drugs globally has raised concerns of diversion from orthodox medicines to herbal remedies. The treatment and management cost of DM in developing countries is expensive and majority of the population cannot afford, hence the heavy reliance on medicinal plants for the management several chronic diseases including diabetes mellitus. Over a thousand plant species have been used in the treatment and management of diabetes. Therapeutic effects of plant extracts have been linked to the presence of phytochemicals, such as glycosides, alkaloids, terpenoids, flavonoids, cartenoids, beta glycans and caretoniods and that the bioactive constituents provide therapeutic effects either by combating reactive oxygen species or acting as hypoglycaemic, anti-hyperglycaemic, anti-inflammatory and apoptotic agents. This Special Issue of the journal will focus on diabetes in general and diabetes and the role of medicinal plants in the treatment and management of diabetes.

Prof. Oluwafemi Oguntibeju
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Diabetes mellitus and medicinal plants
  • Diabetes and oxidative stress
  • Medicinal plants and obesity
  • Oxidative stress and medicinal plants
  • Diabetic complications and medicinal plants
  • Bone health-related diabetes complications and medicinal plants
  • Toxicity and medicinal plants
  • Diabetes-related inflammation and medicinal plants
  • Diabetic-related apoptosis and medicinal plants

Published Papers (8 papers)

View options order results:
result details:
Displaying articles 1-8
Export citation of selected articles as:

Research

Jump to: Review

Open AccessArticle Salidroside Improves Bone Histomorphology and Prevents Bone Loss in Ovariectomized Diabetic Rats by Upregulating the OPG/RANKL Ratio
Molecules 2018, 23(9), 2398; https://doi.org/10.3390/molecules23092398
Received: 16 July 2018 / Revised: 14 September 2018 / Accepted: 18 September 2018 / Published: 19 September 2018
PDF Full-text (3629 KB) | HTML Full-text | XML Full-text
Abstract
Postmenopausal diabetic women have a high risk of fractures. Salidroside has preventive effects on estrogen deficiency-induced osteoporosis and has hypoglycemic effects on diabetes in rats. However, whether salidroside inhibits bone loss in postmenopausal diabetic patients is still unknown. Here, we established a rat
[...] Read more.
Postmenopausal diabetic women have a high risk of fractures. Salidroside has preventive effects on estrogen deficiency-induced osteoporosis and has hypoglycemic effects on diabetes in rats. However, whether salidroside inhibits bone loss in postmenopausal diabetic patients is still unknown. Here, we established a rat model of osteoporosis to investigate the protective effects of salidroside on bone loss induced by ovariectomy combined with diabetes, also investigating the underlying mechanisms. Two-month-old female Sprague-Dawley rats were divided into three equal groups (10 rats in each group): control group (with sham operation, treated with drug vehicle); OVX/T1DM group (ovariectomized diabetic rats); OVX/T1DM-SAL group, comprising ovariectomized diabetic rats treated with salidroside (20 mg/kg body weight) by gavage. The results showed that after 60 consecutive days of treatment, the bone mineral density (BMD) of OVX/T1DM-SAL increased significantly compared with the OVX/T1DM group (p < 0.01). The level of serum bone turnover markers, including alkaline phosphatase (ALP), cross linked c-telopeptide of type I collagen (CTX-1), osteocalcin, N-terminal propeptide of type I procollagen (PINP), and tartrate-resistant acid phosphatase 5b (TRACP 5b) were all increased in the OVX/T1DM group compared with the control (p < 0.01), and those were decreased by salidroside treatment. Meanwhile, the bone histopathological changes were also attenuated, and the bone marrow adipogenesis was inhibited in salidroside treated rats. Moreover, protein and mRNA ratio of bone osteoprotegerin (OPG)/receptor activator of nuclear factor-κB ligand (RANKL) was upregulated in ovariectomized diabetic rats by salidroside treatment. The results above indicated that the protective effect of salidroside on bone loss induced by ovariectomy and diabetes was mainly due to its ability to suppress bone turnover, inhibit bone marrow adipogenesis, and up-regulate the OPG/RANKL ratio. Full article
(This article belongs to the Special Issue Medicinal Plants and Diabetes)
Figures

Figure 1

Open AccessArticle The Chemical Composition and Functional Properties of Essential Oils from Four Species of Schisandra Growing Wild in the Qinling Mountains, China
Molecules 2018, 23(7), 1645; https://doi.org/10.3390/molecules23071645
Received: 8 June 2018 / Revised: 23 June 2018 / Accepted: 30 June 2018 / Published: 5 July 2018
PDF Full-text (1632 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The aim of this study was to investigate the chemical composition and functional properties of the essential oils from the plants Schisandra grandiflora (Wall.) Hook. f. et Thoms, Schisandra rubriflora (Franch). Rehd. et Wils., Schisandra sphenanthera Rehd. et Wils., and Schisandra propinqua (Wall.)
[...] Read more.
The aim of this study was to investigate the chemical composition and functional properties of the essential oils from the plants Schisandra grandiflora (Wall.) Hook. f. et Thoms, Schisandra rubriflora (Franch). Rehd. et Wils., Schisandra sphenanthera Rehd. et Wils., and Schisandra propinqua (Wall.) Baill var. sinensis Oliv. collected in the Qinling Mountains. Under the optimum conditions of the ultrasonic-assisted extraction method, the extraction yields were 7.51% (S. grandiflora), 6.91% (S. rubriflora), 6.11% (S. sphenanthera), and 5.88% (S. propinqua). A total of 86 components were identified from four species of Schisandra and 16 components were shared among the essential oils of all samples with different contents. However, some components were identified only in a certain plant, for example, β-caryophyllen (S. grandiflora), α-bulnesene (S. rubriflora), and α-Chamigrene (S. propinqua). Terpenoids (sesquiterpenes and oxygenated sesquiterpenes), accounting for 73.87–82.08% of the total compounds, were the main components. Meanwhile, the antioxidant activities of the essential oils were evaluated through three free radical scavenging assays and a reducing power assay, which were related to the contents of the individual bioactive composition. These results provide a phytochemical foundation for the use of four species, and for the further study of the identification of Schisandra species. Full article
(This article belongs to the Special Issue Medicinal Plants and Diabetes)
Figures

Graphical abstract

Open AccessArticle Antidiabetic Effect of Cyclocarya paliurus Leaves Depends on the Contents of Antihyperglycemic Flavonoids and Antihyperlipidemic Triterpenoids
Molecules 2018, 23(5), 1042; https://doi.org/10.3390/molecules23051042
Received: 16 April 2018 / Revised: 24 April 2018 / Accepted: 29 April 2018 / Published: 29 April 2018
PDF Full-text (749 KB) | HTML Full-text | XML Full-text
Abstract
Cyclocarya paliurus has been used commonly to treat diabetes in China. However, the effective components and the effect of plant origin remain unclear. In this study, C. paliurus leaves with different chemical compositions were selected from five geographical locations, and their effects on
[...] Read more.
Cyclocarya paliurus has been used commonly to treat diabetes in China. However, the effective components and the effect of plant origin remain unclear. In this study, C. paliurus leaves with different chemical compositions were selected from five geographical locations, and their effects on streptozotocin (STZ)-induced diabetic mice were evaluated with both ethanol and aqueous extracts. Glucose levels, lipid levels, and biomarkers of liver and kidney function were measured. The principal components of both C. paliurus ethanol and aqueous extracts from different geographical locations differed quantitatively and qualitatively. Results showed that C. paliurus extracts with better antihyperglycemic effects were characterized by higher contents of total flavonoids, especially quercetin-3-O-glucuronide and kaempferol-3-O-glucuronide. Furthermore, significantly negative correlations were found between triterpenoids contents and lipid levels. These results revealed the potential antihyperglycemic capacity of C. paliurus flavonoids and the antihyperlipidemic effect of C. paliurus triterpenoids. Thus, we suggest that the composition of C. paliurus compounds might help to design therapeutic alternatives for the treatment of diabetes mellitus. However, geographic origins and the extraction solvents can also affect the effectiveness of the treatment as these factors influence the chemical compositions and thereby the biological activities. Full article
(This article belongs to the Special Issue Medicinal Plants and Diabetes)
Figures

Graphical abstract

Open AccessArticle Anti-Diabetic Effects of Acankoreagenin from the Leaves of Acanthopanax Gracilistylus Herb in RIN-m5F Cells via Suppression of NF-κB Activation
Molecules 2018, 23(4), 958; https://doi.org/10.3390/molecules23040958
Received: 27 March 2018 / Revised: 13 April 2018 / Accepted: 16 April 2018 / Published: 19 April 2018
PDF Full-text (2102 KB) | HTML Full-text | XML Full-text
Abstract
Diabetes mellitus is a chronic degenerative disease that causes long-term complications and represents a serious public health problem. In this manuscript, acankoreagenin isolated from the leaves of Acanthopanax gracilistylus (LAG) is thought to possess excellent anti-diabetic properties. In vitro, anti-diabetic activities were assessed
[...] Read more.
Diabetes mellitus is a chronic degenerative disease that causes long-term complications and represents a serious public health problem. In this manuscript, acankoreagenin isolated from the leaves of Acanthopanax gracilistylus (LAG) is thought to possess excellent anti-diabetic properties. In vitro, anti-diabetic activities were assessed based on the inhibitory activities with α-glucosidase (IC50 13.01 μM), α-amylase (IC50 30.81 μM), and PTP1B (IC50 16.39 μM). Acankoreagenin showed better anti-diabetic effects. Then, an investigation was performed to analyze the insulin secretion effects of the insulin-secreting cell line in RIN-m5F cells. It was found that acankoreagenin could increase the insulin release in RIN-m5F cells. It was also found that acankoreagenin reduced NO production, activity of caspase-3, and the reactive oxygen species levels in the cells injured by processing of cytokines. In western blotting, inactivation of NF-κB signaling was confirmed. Acankoreagenin (20 μM) showed a higher I-κBα expression and lower NF-κB expression than the control group and showed a better expression than the positive control L-NAME (1 mM) (p < 0.05). This study demonstrates the anti-diabetic effects of acankoreagenin in vitro and suggests acankoreagenin might offer therapeutic potential for treating diabetes mellitus. Full article
(This article belongs to the Special Issue Medicinal Plants and Diabetes)
Figures

Graphical abstract

Open AccessArticle Proteomic Analysis of Differentially-Expressed Proteins in the Liver of Streptozotocin-Induced Diabetic Rats Treated with Parkia biglobosa Protein Isolate
Molecules 2018, 23(2), 156; https://doi.org/10.3390/molecules23020156
Received: 29 October 2017 / Revised: 26 December 2017 / Accepted: 19 January 2018 / Published: 24 January 2018
PDF Full-text (522 KB) | HTML Full-text | XML Full-text
Abstract
Protein isolate from Parkia biglobosa seeds is believed to possess excellent anti-diabetic properties. The purpose of this study was to identify differentially expressed proteins in liver of streptozotocin-induced diabetic rats treated with Parkia biglobosa seeds protein isolate (PBPi). In this study, total proteins
[...] Read more.
Protein isolate from Parkia biglobosa seeds is believed to possess excellent anti-diabetic properties. The purpose of this study was to identify differentially expressed proteins in liver of streptozotocin-induced diabetic rats treated with Parkia biglobosa seeds protein isolate (PBPi). In this study, total proteins extracted from rat liver were separated on one-dimensional SDS polyacrylamide gel (1D SDS-PAGE) and stained with Coomassie brilliant blue (CBB) to visualize protein bands. We observed that protein bands in the region of 10–15 kDa were altered by the different treatments; these bands were selected and excised for in-gel digestion and peptide extraction followed by nLC-MS, MALDI-TOF MS, and LIFT MS/MS. A database search with the Mascot algorithm positively identified four differentially expressed proteins. These proteins are known to be responsible for diverse biological functions within various organs and tissues. The present result gives insight and understanding into possible molecular mechanisms by which streptozotocin causes various alterations in proteins found in the liver of diabetic rats and the possible modulatory role of PBPi in the management of streptozotocin-induced diabetes. Full article
(This article belongs to the Special Issue Medicinal Plants and Diabetes)
Figures

Figure 1

Open AccessArticle The Benefits of the Citrus Flavonoid Diosmin on Human Retinal Pigment Epithelial Cells under High-Glucose Conditions
Molecules 2017, 22(12), 2251; https://doi.org/10.3390/molecules22122251
Received: 17 November 2017 / Revised: 2 December 2017 / Accepted: 8 December 2017 / Published: 18 December 2017
PDF Full-text (2526 KB) | HTML Full-text | XML Full-text
Abstract
We investigate diosmin for its effect on the ARPE-19 human retinal pigment epithelial cells exposed to high glucose, a model of diabetic retinopathy (DR). After incubation for 4 days with a normal (5 mmol/L) concentration of D-glucose, ARPE-19 cells were exposed separately to
[...] Read more.
We investigate diosmin for its effect on the ARPE-19 human retinal pigment epithelial cells exposed to high glucose, a model of diabetic retinopathy (DR). After incubation for 4 days with a normal (5 mmol/L) concentration of D-glucose, ARPE-19 cells were exposed separately to normal or high concentrations of D-glucose (30 mmol/L) with or without diosmin at different concentrations (0.1, 1, 10 μg/mL) for another 48 h. Next, we assessed cell viability, reactive oxygen species (ROS) generation and antioxidant enzyme activities. In order to examine the underlying molecular mechanisms, we meanwhile analyzed the expressions of Bax, Bcl-2, total and phosphorylated JNK and p38 mitogen-activated protein kinase (MAPK). Diosmin dose dependently enhanced cell viability following high glucose treatment in ARPE-19 cells. The activities of superoxide dismutase and glutathione peroxidase, as well as the levels of reduced glutathione were decreased, while it was observed that levels of ROS in high glucose cultured ARPE-19 cells increased. High glucose also disturbed Bax and Bcl-2 expression, interrupted Bcl-2/Bax balance, and triggered subsequent cytochrome c release into the cytosol and activation of caspase-3. These detrimental effects were ameliorated dose dependently by diosmin. Furthermore, diosmin could abrogate high glucose-induced apoptosis as well as JNK and P38 MAPK phosphorylation in ARPE-19 cells. Our results suggest that treatment ARPE-19 cells with diosmin halts hyperglycemia-mediated oxidative damage and thus this compound may be a candidate for preventing the visual impairment caused by DR. Full article
(This article belongs to the Special Issue Medicinal Plants and Diabetes)
Figures

Figure 1

Review

Jump to: Research

Open AccessReview Therapeutic Potential of Brazilian Cerrado Campomanesia Species on Metabolic Dysfunctions
Molecules 2018, 23(9), 2336; https://doi.org/10.3390/molecules23092336
Received: 17 August 2018 / Revised: 3 September 2018 / Accepted: 4 September 2018 / Published: 13 September 2018
PDF Full-text (309 KB) | HTML Full-text | XML Full-text
Abstract
Obesity, in conjunction with other metabolic disorders such as insulin resistance and dyslipidemia, is a feature of metabolic syndrome which is characterized by a pro-inflammatory state and increased oxidative stress. Therefore, antioxidant foods are proposed to prevent and treat these disorders. Medicinal plants
[...] Read more.
Obesity, in conjunction with other metabolic disorders such as insulin resistance and dyslipidemia, is a feature of metabolic syndrome which is characterized by a pro-inflammatory state and increased oxidative stress. Therefore, antioxidant foods are proposed to prevent and treat these disorders. Medicinal plants are one of the main strategies in this regard. Guavira, a Brazilian Cerrado plant, contains different bioactive compounds with a high antioxidant capacity and without clinical or reproductive toxicity effects. Though there are different varieties of guavira, the principal Brazilian Cerrado guaviras demonstrated hypoglycemic, anti-inflammatory, and hypocholesterolemic actions. There is also a potential antiplatelet agent in C. xanthocarpa, while C. adamantium displayed hypocholesterolemic actions in animal models and human clinical trials. On the other hand, even with a lack of studies related to C. pubescens, it demonstrated anti-inflammatory effects and an antioxidant capacity in in vitro studies. Despite the fact that most of the studies were not performed to evaluate pathological conditions specific to obese animal models or obese subjects, guavira demonstrated effects in metabolic disorders that are commonly related to the obesity context, such as cardiovascular disturbances and hyperglycemia status. This suggests that guavira is a potential therapeutic approach to obesity-induced metabolic syndrome. Full article
(This article belongs to the Special Issue Medicinal Plants and Diabetes)
Open AccessReview Phytochemicals: Target-Based Therapeutic Strategies for Diabetic Retinopathy
Molecules 2018, 23(7), 1519; https://doi.org/10.3390/molecules23071519
Received: 7 June 2018 / Revised: 18 June 2018 / Accepted: 19 June 2018 / Published: 23 June 2018
PDF Full-text (1903 KB) | HTML Full-text | XML Full-text
Abstract
Background: A variety of causative factors are involved in the initiation of diabetic retinopathy (DR). Current antidiabetic therapies are expensive and not easily accessible by the public. Furthermore, the use of multiple synthetic drugs leads to severe side effects, which worsen the
[...] Read more.
Background: A variety of causative factors are involved in the initiation of diabetic retinopathy (DR). Current antidiabetic therapies are expensive and not easily accessible by the public. Furthermore, the use of multiple synthetic drugs leads to severe side effects, which worsen the diabetic patient’s condition. Medicinal plants and their derived phytochemicals are considered safe and effective treatment and their consumption can reduce the DR risk. In this article, we discuss a variety of medicinal plants, and their noteworthy bio-active constituents, that will be utilized as target based therapeutic strategies for DR. Methods: A broad-spectrum study was conducted using published English works in various electronic databases including Science Direct, PubMed, Scopus, and Google Scholar. Results: Targeting the multiple pathological factors including ROS, AGEs formation, hexosamine flux, PARP, PKC, and MAPK activation through variety of bioactive constituents in medicinal plants, diabetes progression can be delayed with improved loss of vision. Conclusions: Data reveals that traditional herbs and their prominent bioactive components control and normalize pathological cellular factors involved in DR progression. Therefore, studies should be carried out to explore the protective retinopathy effects of medicinal plants using experimental animal and humans models. Full article
(This article belongs to the Special Issue Medicinal Plants and Diabetes)
Figures

Graphical abstract

Back to Top