Photodynamic Therapy in Cancer Treatment

Dear Colleagues,

Photodynamic therapy (PDT) is a clinically approved treatment based on the administration of a photosensitizing molecule, its accumulation in the target tissue, and illumination with light, which is selectively absorbed by the photosensitizer (PS). In fact, the clinical approach of PDT through the combination of the photosensitizer, oxygen, and visible or near-infrared light irradiation leads to the production of cytotoxic reactive oxygen species (ROS), which trigger a cascade of reactions that lead to the destruction of tumor cells and tumor vasculature, making PDT an effective anticancer procedure. In comparison with traditional oncological therapies, PDT has several advantages; it is relatively non-invasive because irradiation is confined to the tumor site, and the photosensitizer accumulates predominantly in cancer cells, thus showing lower systemic toxicity and a relatively selective destruction of neoplastic cells. PDT also has a good tolerability profile, the absence of specific resistance mechanisms, a good cosmetic outcome, and the ability to stimulate the immune system. However, PDT has some limitations, and thus, there is a significant room for improvement, especially in the area of new and more efficient PS molecules. Better PS molecules should be rationally designed and prepared to match, as close as possible, the properties that define the profile of the ideal PS.

The aim of this Special Issue, Photodynamic Therapy in Cancer Treatment, is to provide the latest findings in this research field, namely, new photosensitizers, photochemical and photobiological aspects, targeting, and biological applications. We invite original research papers and comprehensive reviews covering any aspect related to the abovementioned topics.

Prof. Dr. M. Amparo F. Faustino
Dr. Carlos J. P. Monteiro
Dr. Catarina I. V. Ramos
Guest Editors

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