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Special Issue "Chemistry and Pharmacology of Modulators of Oxidative Stress 2018"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 28 February 2019

Special Issue Editors

Guest Editor
Prof. Dr. Luciano Saso

Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Website | E-Mail
Interests: pharmacological applications of modulators of oxidative stress
Guest Editor
Prof. Dr. Neda MIMICA-DUKIĆ

Department of Chemistry, Biochemistry and Environmental production, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3.21000 Novi Sad, Serbia
Website 1 | Website 2 | E-Mail
Interests: chemistry and pharmacology of modulators of oxidative stress
Guest Editor
Prof. Dr. Ryszard AMAROWICZ

Department of Chemical and Physical Properties of Food, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences Poland
Website | E-Mail
Interests: chemistry and pharmacology of modulators of oxidative stress

Special Issue Information

Dear Colleagues,

As we all know, oxidative stress (OS) is involved to many pathologies, ranging from cancer to neurodegenerative diseases, and modulators of OS can be of therapeutic value in some of them, acting by different mechanisms, such as scavenging and metal chelating effects, mimicking the antioxidant enzymes or upregulation of their expression, activating the nuclear factor erythroid 2-related factor 2 (Nrf2), inhibiting pro-oxidant enzymes, etc.

This Special Issue aims to provide a forum for the dissemination of the latest information on new methods for extraction, isolation, synthesis, or derivatization of modulators of OS stress, and on in vitro and in vivo testing of their biological activities in view of possible pharmacological

Prof. Dr. Luciano SASO
Prof. Dr. Neda MIMICA-DUKIĆ
Prof. Dr. Ryszard AMAROWICZ
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress modulators
  • antioxidants
  • pro-oxidants
  • enzymes
  • synthesis
  • chemistry
  • pharmacology
  • polyphenols
  • Nrf2

Published Papers (2 papers)

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Research

Open AccessArticle Correlation of Paraoxonase-1 with the Severity of Crohn’s Disease
Molecules 2018, 23(10), 2603; https://doi.org/10.3390/molecules23102603
Received: 4 September 2018 / Revised: 5 October 2018 / Accepted: 8 October 2018 / Published: 11 October 2018
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Abstract
Diagnostics of Crohn’s disease (CD) requires noninvasive biomarkers facilitating early detection and differentiation of the disease. Therefore, in this study, we aimed to determine the relationship between paraoxonase-1 (PON-1), the severity of CD, oxidative stress, and inflammation in CD. The CD activity index
[...] Read more.
Diagnostics of Crohn’s disease (CD) requires noninvasive biomarkers facilitating early detection and differentiation of the disease. Therefore, in this study, we aimed to determine the relationship between paraoxonase-1 (PON-1), the severity of CD, oxidative stress, and inflammation in CD. The CD activity index was based on the current classification. Plasma PON-1 was measured in 47 patients with CD, and in 23 control volunteers. Using quantitative variables such as receiver operating characteristics (ROC) (area under the curve (AUC)), the diagnostic utility of PON-1 in differentiating the severity of CD was assessed. Circulating PON-1 was found to be decreased in the CD group compared to the control group (269.89 vs. 402.56 U/L, respectively), and it correlated well with the disease activity. PON-1 correlated positively with hemoglobin (Hb) (r = 0.539, p < 0.001), hematocrit (Ht) (r = 0.48, p < 0.001), total cholesterol (TC) (r = 0.343, p < 0.001), high density lipoprotein (HDL) (r = 0.536, p < 0.001), low density lipoprotein (LDL) (r = 0.54, p < 0.001), and triglyceride (TG) (r = 0.561, p < 0.001) and correlated negatively with white blood cell count (WBC) (r = −0.262, p = 0.029), platelet count (PLT) (r = −0.326, p = 0.006), C-reactive protein (CRP) (r = −0.61, p < 0.001), and malondialdehyde (MDA) (r = −0.924, p < 0.001). PON-1 as a marker for CD differentiation possessed a sensitivity and specificity of 93.62% and 91.30%, respectively. CD was found to be associated with the decrease in the levels of PON-1, which correlates well with activity of the disease and reflects the intensification of inflammation, as well as intensified lipid peroxidation. High sensitivity and specificity of PON-1 determines its selection as a good screening test for CD severity. Full article
(This article belongs to the Special Issue Chemistry and Pharmacology of Modulators of Oxidative Stress 2018)
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Open AccessArticle Kaempferol Attenuates ROS-Induced Hemolysis and the Molecular Mechanism of Its Induction of Apoptosis on Bladder Cancer
Molecules 2018, 23(10), 2592; https://doi.org/10.3390/molecules23102592
Received: 30 August 2018 / Revised: 5 October 2018 / Accepted: 8 October 2018 / Published: 10 October 2018
PDF Full-text (2029 KB) | HTML Full-text | XML Full-text
Abstract
Bladder cancer has become the most common malignant urinary carcinoma. Studies have shown that significant antioxidant and bladder cancer-fighting properties of several plant-based diets like Psidium guajava, ginger and amomum, are associated with their high kaempferol content. In this paper, we evaluated
[...] Read more.
Bladder cancer has become the most common malignant urinary carcinoma. Studies have shown that significant antioxidant and bladder cancer-fighting properties of several plant-based diets like Psidium guajava, ginger and amomum, are associated with their high kaempferol content. In this paper, we evaluated the antioxidant and anticancer activities of kaempferol and its mechanism of induction to apoptosis on bladder cancer cells. Our findings demonstrated that kaempferol showed an obvious radical scavenging activity in erythrocytes damaged by oxygen. Kaempferol promoted antioxidant enzymes, inhibited ROS generation and lipid peroxidation and finally prevented the occurrence of hemolysis. Additionally, kaempferol exhibited a strong inhibitory effect on bladder cancer cells and high safety on normal bladder cells. At the molecular level, kaempferol suppressed EJ bladder cancer cell proliferation by inhibiting the function of phosphorylated AKT (p-AKT), CyclinD1, CDK4, Bid, Mcl-1 and Bcl-xL, and promoting p-BRCA1, p-ATM, p53, p21, p38, Bax and Bid expression, and finally triggering apoptosis and S phase arrest. We found that Kaempferol exhibited strong anti-oxidant activity on erythrocyte and inhibitory effects on the growth of cancerous bladder cells through inducing apoptosis and S phase arrest. These findings suggested that kaempferol might be regarded as a bioactive food ingredient to prevent oxidative damage and treat bladder cancer. Full article
(This article belongs to the Special Issue Chemistry and Pharmacology of Modulators of Oxidative Stress 2018)
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