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Natural Compounds and Additives in Veterinary Science: Drawbacks and Advantages

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 5189

Special Issue Editors


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Guest Editor
School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy
Interests: pharmacology; toxicology; nanotechnology
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
University of Bari Aldo Moro, Department of Veterinary Medicine, S.P. n. 62 per Casamassima, km 3, 70010 Valenzano (BA), Italy
Interests: innate immunity; biomarkers of inflammation; antinflammatory drugs; immunomodulators; essential oils; pharmacodymamics (all related to animal species of veterinary interest)

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Guest Editor
Department of Veterinary Medicine, University of Bari “Aldo Moro”, 70010 Valenzano, Italy
Interests: chemotherapy; drug resistance; wild birds; antiparasitic drugs; enterobacteria
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The identification of natural substances that can displace the use of synthetic substances is becoming more and more central in many areas of veterinary science. Indeed, in the animal production sector, natural compounds have the potential to meet increasing consumer demands for safe, healthy, and sustainable foods of animal origin as well as to address concerns about the development and diffusion of antimicrobial resistance, which is leading to the reduced  use of antibiotics in industrial animal farms. Moreover, due to the increasing humanization of companion animals, pet owners desire to provide their pets with human-like products, experiences, and care, showing high compliance with the use of natural and sustainable products in supporting the health and wellbeing of their pets.

However, natural compounds exhibiting potential beneficial properties may require high dosages or produce toxicity and significant adverse effects in animals, and these effects are potentially different from those that occur in humans.

Taking all of these aspects and the importance of sharing knowledge about this unexplored field into account, this Special Issue aims to accommodate original research about compounds of natural origin that can be used in all veterinary sectors, from intensive farming to companion animal care, while paying great attention to the identification and characterization of the efficacy and safety of new molecules or molecular complexes.

Studies about the use of additives or other ingredients in feed or food of animal origin are welcome as well. Reviews will be considered as long as they are mainly focused on veterinary aspects.

Dr. Alessandro Di Cerbo
Dr. Claudia Zizzadoro
Dr. Nicola Pugliese
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural compounds
  • essential oils
  • antibiotics
  • additives
  • antiparasitic
  • anti-inflammatory
  • novel molecular candidates
  • immunomodulatory
  • antioxidant
  • animal products
  • animal health
  • animal welfare
  • sustainability
  • feed
  • food of animal origin

Published Papers (2 papers)

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Research

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17 pages, 2003 KiB  
Article
Dietary Supplementation with Eugenol Nanoemulsion Alleviates the Negative Effects of Experimental Coccidiosis on Broiler Chicken’s Health and Growth Performance
by Mohammad Reza Youssefi, Rahmatollah Alipour, Zahra Fakouri, Mohammad Hassan Shahavi, Nadia Taiefi Nasrabadi, Mohaddeseh Abouhosseini Tabari, Giuseppe Crescenzo, Claudia Zizzadoro and Gerardo Centoducati
Molecules 2023, 28(5), 2200; https://doi.org/10.3390/molecules28052200 - 27 Feb 2023
Cited by 4 | Viewed by 1563
Abstract
The present study investigated the protective efficacy of dietary supplementation with clove essential oil (CEO), its main constituent eugenol (EUG), and their nanoformulated emulsions (Nano-CEO and Nano-EUG) against experimental coccidiosis in broiler chickens. To this aim, various parameters (oocyst number per gram of [...] Read more.
The present study investigated the protective efficacy of dietary supplementation with clove essential oil (CEO), its main constituent eugenol (EUG), and their nanoformulated emulsions (Nano-CEO and Nano-EUG) against experimental coccidiosis in broiler chickens. To this aim, various parameters (oocyst number per gram of excreta (OPG), daily weight gain (DWG), daily feed intake (DFI), feed conversion ratio (FCR), serum concentrations of total proteins (TP), albumin (ALB), globulins (GLB), triglycerides (TG), cholesterol (CHO) and glucose (GLU), serum activity of superoxide dismutase (SOD), glutathione s-transferase (GST), and glutathione peroxidase (GPx)] were compared among groups receiving CEO supplemented feed (CEO), Nano-CEO supplemented feed (Nano-CEO), EUG supplemented feed (EUG), Nano-EUG supplemented feed (Nano-EUG), diclazuril supplemented feed (standard treatment, ST), or basal diet [diseased control (d-CON) and healthy control (h-CON)), from days 1–42. Chickens of all groups, except h-CON, were challenged with mixed Eimeria spp. at 14 days of age. Coccidiosis development in d-CON was associated with impaired productivity (lower DWG and higher DFI and FCR relative to h-CON; p < 0.05) and altered serum biochemistry (decreased TP, ALB, and GLB concentrations and SOD, GST, and GPx activities relative to h-CON; p < 0.05). ST effectively controlled coccidiosis infection by significantly decreasing OPG values compared with d-CON (p < 0.05) and maintaining zootechnical and serum biochemical parameters at levels close to (DWG, FCR; p < 0.05) or not different from (DFI, TP, ALB, GLB, SOD, GST, and GPx) those of h-CON. Among the phytogenic supplemented (PS) groups, all showed decreased OPG values compared with d-CON (p < 0.05), with the lowest value being measured in Nano-EUG. All PS groups showed better values of DFI and FCR than d-CON (p < 0.05), but only in Nano-EUG were these parameters, along with DWG, not different from those of ST. Furthermore, Nano-EUG was the only PS group having all serum biochemical values not different (or even slightly improved) relative to ST and h-CON. In conclusion, the tested PS diets, especially Nano-EUG, can limit the deleterious effects of coccidiosis in broiler chickens, due to anticoccidial activity and possibly their reported antioxidant and anti-inflammatory properties, thereby representing a potential green alternative to synthetic anticoccidials. Full article
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Review

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29 pages, 1643 KiB  
Review
Plant Essential Oils as a Tool in the Control of Bovine Mastitis: An Update
by Alice Caneschi, Anisa Bardhi, Andrea Barbarossa and Anna Zaghini
Molecules 2023, 28(8), 3425; https://doi.org/10.3390/molecules28083425 - 13 Apr 2023
Cited by 5 | Viewed by 2921
Abstract
Bovine mastitis is a major concern for the dairy cattle community worldwide. Mastitis, subclinical or clinical, can be caused by contagious or environmental pathogens. Costs related to mastitis include direct and indirect losses, leading to global annual losses of USD 35 billion. The [...] Read more.
Bovine mastitis is a major concern for the dairy cattle community worldwide. Mastitis, subclinical or clinical, can be caused by contagious or environmental pathogens. Costs related to mastitis include direct and indirect losses, leading to global annual losses of USD 35 billion. The primary treatment of mastitis is represented by antibiotics, even if that results in the presence of residues in milk. The overuse and misuse of antibiotics in livestock is contributing to the development of antimicrobial resistance (AMR), resulting in a limited resolution of mastitis treatments, as well as a serious threat for public health. Novel alternatives, like the use of plant essential oils (EOs), are needed to replace antibiotic therapy when facing multidrug-resistant bacteria. This review aims to provide an updated overview of the in vitro and in vivo studies available on EOs and their main components as an antibacterial treatment against a variety of mastitis causing pathogens. There are many in vitro studies, but only several in vivo. Given the promising results of treatments with EOs, further clinical trials are needed. Full article
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