molecules-logo

Journal Browser

Journal Browser

Wound Infection: Emerging Challenge in Normal and Diabetic Skin Wounds

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 2649

Special Issue Editor


E-Mail Website
Guest Editor
Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA
Interests: wound infection; wound repair; immunotherapy; bugs as drugs; antimicrobial resistance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Wound management is a major global challenge posing a significant burden to patients and healthcare systems. The incidence of diabetes continues to increase in the Western world, and the prevalence of acute and chronic wounds related to this condition continues to be a major focus of wound care research.  Wound healing is an incredibly complex physiological process, with numerous interdependent factors influencing critical events. More than 50% of chronic wounds exhibit signs and symptoms that are consistent with localized bacterial biofilms underlying severe infections that contribute to tissue destruction, delayed wound-healing, and other serious complications. In many diverse pathologies, such as diabetes mellitus, normal wound healing is impaired, which may lead to severe complications, ranging from ulcers to chronic skin infections. As such, advanced biomedical approaches for effective wound care aim at providing antimicrobial protection to the open wound together with promotion of fast and correct healing, so that fully functional healthy skin can be swiftly restored.

The aim of this Special Issue is to highlight recent advances in the efforts that have been made over the past several years to find interventions in wound-healing properties. This Special Issue may include original research articles and reviews working towards the development of new and effective wound care treatments for diabetic and other skin and soft tissue infections.

Dr. Kajal Gupta
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute, chronic, and complex skin wounds
  • wound infection
  • wound repair
  • skin and tissue regeneration
  • diabetic skin wound infection
  • biofilms
  • antibiotic resistance

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

18 pages, 5681 KiB  
Article
3D Printing of pH Indicator Auxetic Hydrogel Skin Wound Dressing
by Filmon Tsegay, Muhammed Hisham, Mohamed Elsherif, Andreas Schiffer and Haider Butt
Molecules 2023, 28(3), 1339; https://doi.org/10.3390/molecules28031339 - 31 Jan 2023
Cited by 8 | Viewed by 2461
Abstract
The benefits of enclosing pH sensors into wound dressings include treatment monitoring of wounded skin and early detection of developing chronic conditions, especially for diabetic patients. A 3D printed re-entrant auxetic hydrogel wound dressing, doped with pH indicator phenol red dye, was developed [...] Read more.
The benefits of enclosing pH sensors into wound dressings include treatment monitoring of wounded skin and early detection of developing chronic conditions, especially for diabetic patients. A 3D printed re-entrant auxetic hydrogel wound dressing, doped with pH indicator phenol red dye, was developed and characterized. The re-entrant auxetic design allows wound dressing adhesion to complex body parts, such as joints on arms and legs. Tensile tests revealed a yield strength of 140 kPa and Young’s modulus of 78 MPa. In addition, the 3D-printed hydrogel has a swelling capacity of up to 14%, limited weight loss to 3% in six days, and porosity of near 1.2%. A reasonable pH response resembling human skin pH (4–10) was obtained and characterized. The integration of color-changing pH indicators allows patients to monitor the wound’s healing process using a smartphone. In addition to the above, the mechanical properties and their dependence on post-processing were studied. The results show that the resin composition and the use of post-treatments significantly affect the quality and durability of the wound dressings. Finally, a poly (acrylic acid) (PAA) and water-based adhesive was developed and used to demonstrate the performance of the auxetic wound dressing when attached to moving body joints. Full article
Show Figures

Figure 1

Back to TopTop