Multifaceted Role of Metalloproteins

Dear Colleagues,

Metalloproteins contain one or more permanently bound metal ions, which can be coordinated to the sidechain of specific aminoacids, can be incorporated into metal cofactors (such as heme, other tetrapyrrolic rings, and molybdopterin), or can form inorganic clusters (such as FeS clusters and FeMo cofactor of nitrogenase).

Metalloproteins play crucial roles in all living organisms, being involved in catalysis and regulation of a wide array of different reactions, in electron transfer chains associated with respiration and photosynthesis, in signaling events, in O₂ transport, in metal ion trafficking, and in replication of the genetic information. Therefore, comprehension of the molecular details of the relationship between their structure and function is mandatory to fully understand their physiological roles. This would greatly contribute to expanding our knowledge of life processes, understanding the molecular basis of diseases, designing metalloprotein-based nanosensors, and devising new environmentally friendly processes for industrial production or detoxification of polluted sites.

The present Special Issue of Molecules entitled “Multifaced Roles of Metalloproteins” welcomes contributions in all areas of basic and application-oriented research associated with metalloproteins from the aspects of coordination chemistry, biophysics, biochemistry, and molecular biology.

Dr. Gianantonio Battistuzzi
Dr. Carlo Augusto Bortolotti
Guest Editors

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