Aromatic Heterocyclic Compounds: Synthesis, Reactivity and Applications
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 142
Special Issue Editor
Interests: organic synthesis; synthetic organic chemistry; heterocyclic chemistry; pharmaceutical chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Aromatic heterocyclic compounds represent a large place in organic chemistry. Considered as bioisosters of benzene, they are often used to replace the latter ring when exploring variations in biological or pharmaceutical activities. Some interesting activities can result from the presence of the heteroatom(s) and new binding sites that appear for docking on receptors. This class of compounds can be synthesized directly with different functions depending on the starting material. On the other hand, using the very special reactivity of the nucleus, functions can be introduced afterward by classical electrophilic reactions or metalation. Depending on the heterocycle used, even aromatic nucleophilic reactions are possible.
Many natural compounds contain aromatic heterocyclic moiety. This presents a challenge for the total synthesis of these natural compounds. The presence of different heteroatoms in the nucleus presents another challenge to synthesis or reactivity studies of such derivatives. Aromatic heterocycles are also used as intermediates for the construction of non-heterocyclic compounds (Padwa, Boger, Katritzky…). In this case, the heterocycle, used as a pivotal compound, disappears in the final step.
This class of products finds application not only in the medicinal domain but also in polymer chemistry and in material science, among many others.
Due to the number of possible aromatic heterocycles that exist, they will always remain an interesting and challenging field of organic chemistry.
Dr. Gilbert Kirsch
Guest Editor
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Keywords
- aromatic heterocycles with one heteroatom
- aromatic heterocycles with two or more heteroatoms
- condensed compounds containing an aromatic heterocycle
- direct synthesis
- synthesis using electrophilic or nucleophilic reactions, metalation and reactivity
- applications of aromatic heterocyclic compounds
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