Aromatic Heterocyclic Compounds: Synthesis, Reactivity and Applications
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 15
Special Issue Editor
Interests: organic synthesis; synthetic organic chemistry; heterocyclic chemistry; pharmaceutical chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Aromatic heterocyclic compounds represent a large place in organic chemistry. Considered as bioisosters of benzene, they are often used to replace the latter ring when exploring variations in biological or pharmaceutical activities. Some interesting activities can result from the presence of the heteroatom(s) and new binding sites that appear for docking on receptors. This class of compounds can be synthesized directly with different functions depending on the starting material. On the other hand, using the very special reactivity of the nucleus, functions can be introduced afterward by classical electrophilic reactions or metalation. Depending on the heterocycle used, even aromatic nucleophilic reactions are possible.
Many natural compounds contain aromatic heterocyclic moiety. This presents a challenge for the total synthesis of these natural compounds. The presence of different heteroatoms in the nucleus presents another challenge to synthesis or reactivity studies of such derivatives. Aromatic heterocycles are also used as intermediates for the construction of non-heterocyclic compounds (Padwa, Boger, Katritzky…). In this case, the heterocycle, used as a pivotal compound, disappears in the final step.
This class of products finds application not only in the medicinal domain but also in polymer chemistry and in material science, among many others.
Due to the number of possible aromatic heterocycles that exist, they will always remain an interesting and challenging field of organic chemistry.
Dr. Gilbert Kirsch
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- aromatic heterocycles with one heteroatom
- aromatic heterocycles with two or more heteroatoms
- condensed compounds containing an aromatic heterocycle
- direct synthesis
- synthesis using electrophilic or nucleophilic reactions, metalation and reactivity
- applications of aromatic heterocyclic compounds
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.