Synthesis, Characterization and Specific Antimicrobial and Photodegradation Properties of Azines

Dear Colleagues,

One of the significant problems in medicine today is increasing antimicrobial resistance. Due to the misuse of drugs and their abundance in the environment, microorganisms are constantly exposed to the therapeutic agents that are supposed to fight them. This inevitably leads to the creation of microbes capable of surviving the action of these compounds. Hence, many therapies based on conventional antimicrobial agents are ineffective. An alternative approach to addressing this problem is photodynamic antimicrobial chemotherapy, which generates reactive oxygen species in a process called photosensitization. These molecules eagerly attack and deactivate cell structures, eventually leading to cell death.

An organic dye that is considered advantageous for photodynamic antimicrobial chemotherapy is methylene blue. In theory, the designed molecules possess enhanced photo-antimicrobial properties, which will be checked using various physicochemical and microbiological tests. These microbiological trials will allow us to determine the relationship between the structure of a molecule and its efficiency in photodynamic antimicrobial chemotherapy.

This Special Issue welcomes the submission of papers based on original research or reviews that describe the innovative sustainable organic or organometallic reactions, methodologies, and their applications, ranging from mechanistic aspects or, in application in catalysis, the immobilization of the complexes into mesoporous materials.

This issue welcomes the submission of papers based on original research or reviews in the following areas:

• The synthesis of novel azine-based scaffolds.
• Applications of these scaffolds as therapeutic agents in medicinal chemistry.
• A detailed explanation of the structure–activity relationship of synthesized phenothiazine compounds.
• Docking studies supported by experimental validation.

Dr. Jacek Nycz
Guest Editor

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• photocatalytic activity
• synthesis and reactivity
• spectroscopy
• reaction mechanism
• structural and spectroscopic characterization
• electrochemistry