Small Molecules Targeting Age-Related Diseases
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 59
Special Issue Editors
Interests: hydrogen sulfide (H2S); cardiovascular system; ageing; potassium channels; mitochondria
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In 2024, the World Health Organization announced that “By 2030, 1 in 6 people in the world will be aged 60 years or over. At this time the share of the population aged 60 years and over will increase from 1 billion in 2020 to 1.4 billion. By 2050, the world’s population of people aged 60 years and older will double (2.1 billion). The number of persons aged 80 years or older is expected to triple between 2020 and 2050 to reach 426 million”.
It is known that elderly people can be affected, more easily, by chronic diseases, negatively impacting their quality of life and increasing the associated personal and socioeconomical burdens; thus, the treatment and prevention of age-related diseases has become essential in ensuring a healthy lifestyle. Several cellular targets have been identified, including the sirtuins family, and are currently being investigated as a topic of natural as well as synthetic-derived small molecules. In this scenario, the aim of this Special Issue entitled “Small Molecules Targeting Age-Related Diseases” is to collect the more recent results about the application of isolated molecules or extracts obtained from the natural kingdom, but also the synthesis and application of small molecules, even natural-inspired ones, in the prevention and treatment of age-related pathologies, like cardiovascular, neurodegenerative, and metabolic diseases.
We invite contributions of original studies or reviews from the literature on (1) providing insights into the cellular and molecular mechanisms of action of well-known molecules, (2) evaluating the effectiveness of small molecules in not-yet-considered age-related diseases, and (3) proving the development of original small molecules, even those obtained from natural sources to improve their pharmacokinetic or pharmacodynamic properties.
Dr. Lara Testai
Dr. Marco Lessi
Guest Editors
Manuscript Submission Information
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Keywords
- age-related diseases
- small molecules
- cardiovascular diseases
- neurodegenerative diseases
- metabolic disorders
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