Metal Complexes in Drug Research
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 3797
Special Issue Editor
Special Issue Information
Dear Colleagues,
Metals, each owing to their specific chemical properties and biological function, such as different coordination geometries, complex stability constants, redox properties, and transport across membranes, have found important applications in current drug research. Metals have been used in medicine for centuries, but certainly with Rosenberg’s discovery of cisplatin, the design and development of metallodrugs have gained full momentum. Metal-based compounds currently in clinical development have shown promising potential in the treatment of cancer, neurodegenerative, inflammatory, autoimmune, as well as psychiatric diseases. Metal complexes have also been shown to possess antimicrobial properties, including antibacterial, antiviral, antifungal and antiparasitic. The increased need for further development of new selective and efficient drugs is essential at this time, when the world battles global pandemics, and the rising problem of antimicrobial resistance.
This Special issue focuses on the design of novel, and the repurposing of old metallodrugs, their mechanism of interaction with biomolecular targets, and their role as metal-delivery vehicles to cells. Furthermore, the emphasis is on innovative analytical and physicochemical techniques used for the characterization of metals in drug discovery, and in vivo tracking and imaging.
Dr. Ana D. Popović-Bijelić
Guest Editor
Manuscript Submission Information
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Keywords
- antibacterial
- anticancer
- antimicrobial
- metallodrug
- metal imaging and tracking
- SARS CoV 2
