Hybrid Catalysts for Asymmetric Catalysis

Dear Colleagues,

Biological macromolecules, in general, possess the ability to selectively discriminate substrates and represent a target for specific active molecules. Otherwise, there are many chemical transformations catalyzed by transition metals, which have not been observed to occur enzymatically. Starting from these premises, a hybrid catalyst may combine some of the most attractive features of homogeneous and enzymatic catalysts. The development of a hybrid catalyst results, in fact, from the combination of a biomolecular scaffold (e.g., proteins, DNA, or peptides) with an active catalytic moiety. The three key parameters in the design of an artificial metalloenzyme can be summarized by the choice of transition metal catalyst, principally guided by the desired catalytic activity; by the choice of biomolecular scaffold, through two different strategies, de novo design or the modification of an existing natural enzyme or protein; and, finally, by the attachment mode between the transition metal catalyst and the scaffold.

This Special Issue covers all the indicated aspects of the design of a hybrid catalyst and its applications in asymmetric catalytic reactions, both as original research articles and as reviews.

Dr. Isabella Rimoldi
Guest Editor

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