Synthesis and Application of Disulfide Compounds
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 8
Special Issue Editors
Interests: organic chemistry; medicinal chemistry; prodrugs; molecular imaging; glycomimetics
Special Issue Information
Dear Colleagues,
This Special Issue of Molecules is dedicated to the Synthesis and biological application of disulfide-containing small molecules and polymers. Disulfides play a crucial role in both biology and chemistry. They play an essential role in the formation and stabilization of secondary and tertiary structures in peptides and proteins, as well as in maintaining redox homeostasis. Chemically, disulfides are unique due to their high versatility and orthogonal reactivity. This is a reversible functional group, easily formed under oxidative conditions and reduced through a thiol-disulfide exchange reaction. This feature has been particularly attractive for the design of bioreductive prodrugs, antibacterial reagents, and drug delivery systems. Indeed, disulfides can be found in a wide variety of compounds, such as natural products and pharmaceuticals. Interest in this functional group has been extended to carbohydrate chemistry, specifically in the form of glycomimetics, which have multiple other applications, such as in food chemistry and as a tether in fragment-based discovery approaches to identify and optimize potential drug candidates. Additionally, the disulfide bond is a common type of dynamic covalent bond. Due to its moderate bond energy, it maintains the stability of covalent bonds while exhibiting a certain degree of dynamic reversibility. Introducing dynamic disulfide bonds into traditional polymer materials can impart novel properties, such as self-healing and stimulus responsiveness.
In this Special Issue, we are seeking papers on recent methodologies for preparing disulfide bonds, as well as the versatile applications of these compounds. Communications, full-length research articles, and Reviews are welcome.
Dr. Goreti Ribeiro Morais
Prof. Dr. Jinlin He
Guest Editors
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Keywords
- organic chemistry
- poly(disulfide)s
- dithioglycosides
- cyclization of peptides
- drug discovery
- chemical biology
- prodrug development
- dynamic and recyclable material
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