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Special Issue "Catechins in Human Health"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 October 2019

Special Issue Editor

Guest Editor
Prof. Saverio Bettuzzi

University of Parma, Parma, Italy
Website | E-Mail
Phone: +39-0521-033803
Interests: clusterin; catechins; polyphenols; chemoprevention; prostate cancer; cell growth control; polyamines

Special Issue Information

Dear Colleagues,

Catechins are a family of polyphenols which have attracted the scientific interest of many scientists because of their important biological properties. Green tea is one of the most abundant sources of catechins in the human diet, but these molecules can be found in many other plant products. Among them, epigallocatechin-gallate (EGCG) is the most abundant and biologically active catechin. Catechins are widely studied, mostly because they provide many benefits for human health, like anticancer, antiviral and anti-inflammatory action, and have been found useful for treating obesity, diabetes, metabolic syndrome, and cardiovascular and neurological diseases. Additionally, the molecular mechanisms explaining their action have been deeply investigated, leading to the identification of key signalling pathways, novel potential pharmacological targets, and revealing intriguing synergistic actions with known drugs. This Special Issue aims to review the beneficial effects of catechins on human health as demonstrated by controlled research studies and clinical trials as well, in which the risk–benefit ratio has also been considered.

Prof. Saverio Bettuzzi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Catechins
  • Nutrients and diet
  • Prevention
  • Mechanism of action
  • Health benefits
  • Cancer
  • Inflammation

Published Papers (2 papers)

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Research

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Open AccessArticle
Effect of Stereochemical Configuration on the Transport and Metabolism of Catechins from Green Tea across Caco-2 Monolayers
Molecules 2019, 24(6), 1185; https://doi.org/10.3390/molecules24061185
Received: 4 March 2019 / Revised: 20 March 2019 / Accepted: 22 March 2019 / Published: 26 March 2019
PDF Full-text (2695 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The transcellular transport and metabolism of eight green tea catechins (GTCs) were studied in Caco-2 monolayers, with the aim of investigating the effect of cis–trans isomerism on the membrane permeability and biotransformation of GTCs. The results showed that the catechin stereochemistry significantly affects [...] Read more.
The transcellular transport and metabolism of eight green tea catechins (GTCs) were studied in Caco-2 monolayers, with the aim of investigating the effect of cis–trans isomerism on the membrane permeability and biotransformation of GTCs. The results showed that the catechin stereochemistry significantly affects the efflux transport rather than the absorption transport in the Caco-2 monolayers. The trans catechins showed a better transcellular permeability than their corresponding cis (epi) catechins in the efflux transport, as the efflux amount of trans catechins were all significantly higher than that of the cis (epi) catechins at each concentration and each time point tested. Moreover, the relative contents of the (+)-catechin (C)-O-sulfate, (+)-gallocatechin (GC)-O-sulfate, (−)-catechin gallate (CG)-O-sulfate, and (−)-gallocatechin gallate (GCG)-O-sulfate in the efflux transport were 2.67, 16.08, 50.48, and 31.54 times higher than that of the (−)-epicatechin (EC)-O-sulfate, (−)-epigallocatechin (EGC)-O-sulfate, (−)-epicatechin gallate (ECG)-O-sulfate, and (−)-epigallocatechin gallate (EGCG)-O-sulfate, respectively. It indicated that more metabolites were observed after the transcellular efflux of trans catechins. Furthermore, after two hours of incubation, the GTCs could significantly increase the expression of multidrug resistance-associated protein 2 (MRP2) and breast cancer-resistance protein (BCRP), and decrease the expression of P-glycoprotein in the Caco-2 cells. The regulation of GTCs on P-glycoprotein, MRP2, and BCRP could also be significantly influenced by the chemical and dimensional structure. In a conclusion, catechin stereochemistry significantly affects the transport and metabolism of GTCs when refluxed in the Caco-2 monolayers. Full article
(This article belongs to the Special Issue Catechins in Human Health)
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Review

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Open AccessReview
Inhibitory Effects of (−)-Epigallocatechin-3-gallate on Esophageal Cancer
Molecules 2019, 24(5), 954; https://doi.org/10.3390/molecules24050954
Received: 5 February 2019 / Revised: 24 February 2019 / Accepted: 4 March 2019 / Published: 8 March 2019
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Abstract
There is epidemiological evidence showing that drinking green tea can lower the risk of esophageal cancer (EC). The effect is mainly attributed to tea polyphenols and their most abundant component, (−)-epigallocatechin-3-gallate (EGCG). The possible mechanisms of tumorigenesis inhibition of EGCG include its suppressive [...] Read more.
There is epidemiological evidence showing that drinking green tea can lower the risk of esophageal cancer (EC). The effect is mainly attributed to tea polyphenols and their most abundant component, (−)-epigallocatechin-3-gallate (EGCG). The possible mechanisms of tumorigenesis inhibition of EGCG include its suppressive effects on cancer cell proliferation, angiogenesis, DNA methylation, metastasis and oxidant stress. EGCG modulates multiple signal transduction and metabolic signaling pathways involving in EC. A synergistic effect was also observed when EGCG was used in combination with other treatment methods. Full article
(This article belongs to the Special Issue Catechins in Human Health)
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