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Special Issue "Biomedical Hydrogels: Synthesis, Design and Applications"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Applied Chemistry".

Deadline for manuscript submissions: 31 August 2022 | Viewed by 1542

Special Issue Editors

Prof. Dr. Li Ming Zhang
E-Mail Website
Guest Editor
Polymer Research Institute, Sun Yat-sen (Zhongshan) University, Guangzhou 510275, China
Interests: biomaterials; hydrogels; nanoparticles; biopolymers; functional nanocomposites
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Tze-Wen Chung
E-Mail Website
Guest Editor
Department of Biomedical Engineering, National Yang-Ming University, Taipei 11221, Taiwan
Interests: biomaterials; hydrogels; surface modifications; tissue engineering; functional nanoparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural, synthetic, and composite hydrogels have received great attentions for wide biomedical applications. The advances have been achieved in both physically or chemically crosslinked hydrogels. In physically crosslinked hydrogels, the interactions between polymers chains in amphiphilic block and graft copolymers are established by ionic or hydrophobic interactions. In chemically crosslinked hydrogels, the covalent bonds are formed between polymer chains. The crosslinks hydrogels can be generated by radical polymerization, chemical reaction of complementary groups and enzymes. To explore novel biomedical functions, composite hydrogels were widely designed and developed. In this special issue, we will discuss and review recent progress in synthesis, design and applications of varying types of biomedical hydrogels for drug delivery, cell encapsulation, tissue engineering and varying aspects of biomedical applications including self-healing properties.

Prof. Dr. Li Ming Zhang
Prof. Dr. Tze-Wen Chung
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Hydrogels
  • Drug delivery
  • Cell encapsulation
  • Tissue engineering
  • Biomedical applications

Published Papers (2 papers)

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Research

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Article
Synthesis of Fibrin-Type I Collagen Biomaterials via an Acidic Gel
Molecules 2022, 27(7), 2099; https://doi.org/10.3390/molecules27072099 - 24 Mar 2022
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Abstract
Fibrin-Type I collagen composite gels have been widely studied as biomaterials, in which both networks are usually formed simultaneously at a neutral pH. Here, we describe a new protocol in which mixed concentrated solutions of collagen and fibrinogen were first incubated at acidic [...] Read more.
Fibrin-Type I collagen composite gels have been widely studied as biomaterials, in which both networks are usually formed simultaneously at a neutral pH. Here, we describe a new protocol in which mixed concentrated solutions of collagen and fibrinogen were first incubated at acidic pH to induce fibrinogen gel formation, followed by a pH change to neutral inducing collagen fiber formation. Thrombin was then added to form fibrin-collagen networks. Using this protocol, mixed gels containing 20 mg.mL−1 fibrin and up to 10 mg.mL−1 collagen could be prepared. Macroscopic observations evidenced that increasing the content of collagen increases the turbidity of the gels and decreases their shrinkage during the fibrinogen-to-fibrin conversion. The presence of collagen had a minor influence on the rheological properties of the gels. Electron microscopy allowed for observation of collagen fibers within the fibrin network. 2D cultures of C2C12 myoblasts on mixed gels revealed that the presence of collagen favors proliferation and local alignment of the cells. However, it interferes with cell differentiation and myotube formation, suggesting that further control of in-gel collagen self-assembly is required to elaborate fully functional biomaterials. Full article
(This article belongs to the Special Issue Biomedical Hydrogels: Synthesis, Design and Applications)
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Review

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Review
Hydrogels: Properties and Applications in Biomedicine
Molecules 2022, 27(9), 2902; https://doi.org/10.3390/molecules27092902 - 02 May 2022
Viewed by 526
Abstract
Hydrogels are crosslinked polymer chains with three-dimensional (3D) network structures, which can absorb relatively large amounts of fluid. Because of the high water content, soft structure, and porosity of hydrogels, they closely resemble living tissues. Research in recent years shows that hydrogels have [...] Read more.
Hydrogels are crosslinked polymer chains with three-dimensional (3D) network structures, which can absorb relatively large amounts of fluid. Because of the high water content, soft structure, and porosity of hydrogels, they closely resemble living tissues. Research in recent years shows that hydrogels have been applied in various fields, such as agriculture, biomaterials, the food industry, drug delivery, tissue engineering, and regenerative medicine. Along with the underlying technology improvements of hydrogel development, hydrogels can be expected to be applied in more fields. Although not all hydrogels have good biodegradability and biocompatibility, such as synthetic hydrogels (polyvinyl alcohol, polyacrylamide, polyethylene glycol hydrogels, etc.), their biodegradability and biocompatibility can be adjusted by modification of their functional group or incorporation of natural polymers. Hence, scientists are still interested in the biomedical applications of hydrogels due to their creative adjustability for different uses. In this review, we first introduce the basic information of hydrogels, such as structure, classification, and synthesis. Then, we further describe the recent applications of hydrogels in 3D cell cultures, drug delivery, wound dressing, and tissue engineering. Full article
(This article belongs to the Special Issue Biomedical Hydrogels: Synthesis, Design and Applications)
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