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Nanomedicines: Advanced Design and Therapeutic Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 2785

Special Issue Editors

Department of Food Quality and Safety/National R&D Center for Chinese Herbal Medicine Processing, College of Engineering, China Pharmaceutical University, Nanjing 211198, China
Interests: protein; nanoparticle; delivery system; function; colitis; mushroom

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Guest Editor
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo University, Ningbo 315211, China
Interests: gut microbiota; peptide; lipid; colitis; hyperuricemia; metabolic syndrome; natural products
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710119, China
Interests: carbohydrate; food function; gut microbiota; metabonomics

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Guest Editor Assistant
1. School of Life Sciences, Shaoxing University, Shaoxing 312010, China
2. National Engineering Research Center for Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Wuxi 214122, China
Interests: nano-encapsulation; polyphenols; function; food additive; food microorganism

Special Issue Information

Dear Colleagues,

Current science and engineering have refined nanotechnology further and further, and their achievements can point towards more advanced developments, such as nanomedicine. The aim of nanomedicine is the comprehensive monitoring, control, construction, repair, defense, and improvement of human biological systems at the molecular level ultimately to achieve medical and human wellness benefits. The integration of nanoscale technologies with the practice of food and medicine will alter profoundly our approach to the diagnosis, treatment, and prevention of disease. Additionally, nano compounds used in food and medicine areas can be applied in nano-drug delivery systems, nano-encapsulation of bioactive compounds, nutrient carriers and food additives. We believe that a Special Issue can aid in promoting this research subject, which has presented many innovative solutions to common problems. We welcome high-quality reviews or research articles for this Special Issue. The topics of this Special Issue include, but are not limited to, those in the above introduction.

Dr. Biao Yuan
Dr. Chenyang Lu
Dr. Daoyuan Ren
Guest Editors

Dr. Xiao Xu
Guest Editor Assistant

Manuscript Submission Information

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Keywords

  • nanomedicine
  • therapeutic
  • functional compounds
  • delivery
  • disease

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Published Papers (1 paper)

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Research

14 pages, 3526 KiB  
Article
Berberine-Based Carbon Quantum Dots Improve Intestinal Barrier Injury and Alleviate Oxidative Stress in C57BL/6 Mice with 5-Fluorouracil-Induced Intestinal Mucositis by Enhancing Gut-Derived Short-Chain Fatty Acids Contents
by Liang Wu, Yue Xi, Man Yan, Chang Sun, Jiajun Tan, Jiayuan He, Haitao Li and Dongxu Wang
Molecules 2023, 28(5), 2148; https://doi.org/10.3390/molecules28052148 - 24 Feb 2023
Cited by 8 | Viewed by 2444
Abstract
This study aims to evaluate the effect of berberine-based carbon quantum dots (Ber-CDs) on improving 5-fluorouracil (5-FU)-induced intestinal mucositis in C57BL/6 mice, and explored the mechanisms behind this effect. Thirty-two C57BL/6 mice were divided into four groups: normal control (NC), 5-FU-induced intestinal mucositis [...] Read more.
This study aims to evaluate the effect of berberine-based carbon quantum dots (Ber-CDs) on improving 5-fluorouracil (5-FU)-induced intestinal mucositis in C57BL/6 mice, and explored the mechanisms behind this effect. Thirty-two C57BL/6 mice were divided into four groups: normal control (NC), 5-FU-induced intestinal mucositis model (5-FU), 5-FU + Ber-CDs intervention (Ber-CDs), and 5-FU + native berberine intervention (Con-CDs). The Ber-CDs improved body weight loss in 5-FU-induced mice with intestinal mucositis compared to the 5-FU group. The expressions of IL-1β and NLRP3 in spleen and serum in Ber-CDs and Con-Ber groups were significantly lower than those in the 5-FU group, and the decrease was more significant in the Ber-CDs group. The expressions of IgA and IL-10 in the Ber-CDs and Con-Ber groups were higher than those in the 5-FU group, but the up-regulation was more significant in the Ber-CDs group. Compared with the 5-FU group, the relative contents of Bifidobacterium, Lactobacillus and the three main SCFAs in the colon contents were significantly increased the Ber-CDs and Con-Ber groups. Compared with the Con-Ber group, the concentrations of the three main short-chain fatty acids in the Ber-CDs group were significantly increased. The expressions of Occludin and ZO-1 in intestinal mucosa in the Ber-CDs and Con-Ber groups were higher than those in the 5-FU group, and the expressions of Occludin and ZO-1 in the Ber-CDs group were more higher than that in the Con-Ber group. In addition, compared with the 5-FU group, the damage of intestinal mucosa tissue in the Ber-CDs and Con-Ber groups were recovered. In conclusion, berberine can attenuate intestinal barrier injury and oxidative stress in mice to mitigate 5-fluorouracil-induced intestinal mucositis, moreover, the above effects of Ber-CDs were more significant than those of native berberine. These results suggest that Ber-CDs may be a highly effective substitute for natural berberine. Full article
(This article belongs to the Special Issue Nanomedicines: Advanced Design and Therapeutic Applications)
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