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Molecules
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Nanomedicines: Advanced Design and Therapeutic Applications
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Nanomedicines: Advanced Design and Therapeutic Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 2830

Special Issue Editors

Dr. Biao Yuan

E-Mail Website
Guest Editor
Department of Food Quality and Safety/National R&D Center for Chinese Herbal Medicine Processing, College of Engineering, China Pharmaceutical University, Nanjing 211198, China
Interests: protein; nanoparticle; delivery system; function; colitis; mushroom
Dr. Chenyang Lu

E-Mail Website
Guest Editor
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo University, Ningbo 315211, China
Interests: gut microbiota; peptide; lipid; colitis; hyperuricemia; metabolic syndrome; natural products
Special Issues, Collections and Topics in MDPI journals
Dr. Daoyuan Ren

E-Mail Website
Guest Editor
Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710119, China
Interests: carbohydrate; food function; gut microbiota; metabonomics
Dr. Xiao Xu

E-Mail Website
Guest Editor Assistant
1. School of Life Sciences, Shaoxing University, Shaoxing 312010, China
2. National Engineering Research Center for Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Wuxi 214122, China
Interests: nano-encapsulation; polyphenols; function; food additive; food microorganism

Special Issue Information

Dear Colleagues,

Current science and engineering have refined nanotechnology further and further, and their achievements can point towards more advanced developments, such as nanomedicine. The aim of nanomedicine is the comprehensive monitoring, control, construction, repair, defense, and improvement of human biological systems at the molecular level ultimately to achieve medical and human wellness benefits. The integration of nanoscale technologies with the practice of food and medicine will alter profoundly our approach to the diagnosis, treatment, and prevention of disease. Additionally, nano compounds used in food and medicine areas can be applied in nano-drug delivery systems, nano-encapsulation of bioactive compounds, nutrient carriers and food additives. We believe that a Special Issue can aid in promoting this research subject, which has presented many innovative solutions to common problems. We welcome high-quality reviews or research articles for this Special Issue. The topics of this Special Issue include, but are not limited to, those in the above introduction.

Dr. Biao Yuan
Dr. Chenyang Lu
Dr. Daoyuan Ren
Guest Editors

Dr. Xiao Xu
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomedicine
  • therapeutic
  • functional compounds
  • delivery
  • disease

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

14 pages, 3526 KiB  
Article
Berberine-Based Carbon Quantum Dots Improve Intestinal Barrier Injury and Alleviate Oxidative Stress in C57BL/6 Mice with 5-Fluorouracil-Induced Intestinal Mucositis by Enhancing Gut-Derived Short-Chain Fatty Acids Contents
by Liang Wu, Yue Xi, Man Yan, Chang Sun, Jiajun Tan, Jiayuan He, Haitao Li and Dongxu Wang
Molecules 2023, 28(5), 2148; https://doi.org/10.3390/molecules28052148 - 24 Feb 2023
Cited by 8 | Viewed by 2484
Abstract
This study aims to evaluate the effect of berberine-based carbon quantum dots (Ber-CDs) on improving 5-fluorouracil (5-FU)-induced intestinal mucositis in C57BL/6 mice, and explored the mechanisms behind this effect. Thirty-two C57BL/6 mice were divided into four groups: normal control (NC), 5-FU-induced intestinal mucositis [...] Read more.
This study aims to evaluate the effect of berberine-based carbon quantum dots (Ber-CDs) on improving 5-fluorouracil (5-FU)-induced intestinal mucositis in C57BL/6 mice, and explored the mechanisms behind this effect. Thirty-two C57BL/6 mice were divided into four groups: normal control (NC), 5-FU-induced intestinal mucositis model (5-FU), 5-FU + Ber-CDs intervention (Ber-CDs), and 5-FU + native berberine intervention (Con-CDs). The Ber-CDs improved body weight loss in 5-FU-induced mice with intestinal mucositis compared to the 5-FU group. The expressions of IL-1β and NLRP3 in spleen and serum in Ber-CDs and Con-Ber groups were significantly lower than those in the 5-FU group, and the decrease was more significant in the Ber-CDs group. The expressions of IgA and IL-10 in the Ber-CDs and Con-Ber groups were higher than those in the 5-FU group, but the up-regulation was more significant in the Ber-CDs group. Compared with the 5-FU group, the relative contents of Bifidobacterium, Lactobacillus and the three main SCFAs in the colon contents were significantly increased the Ber-CDs and Con-Ber groups. Compared with the Con-Ber group, the concentrations of the three main short-chain fatty acids in the Ber-CDs group were significantly increased. The expressions of Occludin and ZO-1 in intestinal mucosa in the Ber-CDs and Con-Ber groups were higher than those in the 5-FU group, and the expressions of Occludin and ZO-1 in the Ber-CDs group were more higher than that in the Con-Ber group. In addition, compared with the 5-FU group, the damage of intestinal mucosa tissue in the Ber-CDs and Con-Ber groups were recovered. In conclusion, berberine can attenuate intestinal barrier injury and oxidative stress in mice to mitigate 5-fluorouracil-induced intestinal mucositis, moreover, the above effects of Ber-CDs were more significant than those of native berberine. These results suggest that Ber-CDs may be a highly effective substitute for natural berberine. Full article
(This article belongs to the Special Issue Nanomedicines: Advanced Design and Therapeutic Applications)
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