Special Issue "Aptamers: Past, Present, and Future"
Deadline for manuscript submissions: closed (15 September 2015).
Interests: stem cells; aptamers; antibodies; Large-scale cultivation of human adhering cells; Dynamic growth medium technology (development of aptamer-based biosensors)
Interests: heterocycles; microwave-induced synthesis; medicinal chemistry; green chemistry
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Nucleic acid aptamer libraries are large arrays of randomly distributed (usually 40-60 nucleotides long) single-stranded nucleic acid molecules, provided with fixed 5’ and 3’ ends.
Individual aptamers display numerous sequence-dependent folds (“cavities”) capable of accommodating small molecules, as well as molecular clusters (“aptatopes”) present on target molecules (generally proteins). Following 8-12 rounds of in vitro selection by the SELEX method (Systematic Evolution of Ligands by EXponential enrichment), it is possible to generate aptamers with increased affinity and specificity towards a given target.
Due to their huge sequence complexity (1014–1015 combinatorial variants), aptamer libraries constitute unique tools for clinicians, pharma, and biotech industries to develop innovative applications, including human primary/pluripotent stem cells low-abundance protein atlases, the elimination of trace contaminants during monoclonal antibody purification, etc.
Cell-specific aptamer probes for intracellular and membrane proteins, the construction of biosensors, miniaturized biological circuits, and artificial extracellular matrix-based scaffolds represent many developments that critically depend upon aptamers. These developments open new avenues for clinical applications in oncology, diabetes, cardiovascular diseases, etc.
This Special Issue aims to be a forum for newcomers and specialists, and will provide an opportunity for them to present recent and novel results in the blooming field of aptamers technology and applications.
Dr. Alain O.A. Miller
Dr. Jean Jacques Vanden Eynde
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- nuclei acids
- Cell-specific aptamers (cell sorting)
- Organismal proteome of low abundance proteins
- Therapeutic aptamers (pri-miRNA/siRNA/nanoparticles)