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New Promising Therapeutic Applications of Biosynthesis Nanomaterials: Outcome and Pathways

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 2456

Special Issue Editors


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Guest Editor
Saveetha Dental College and Hospital, Saveetha Institute of Medical And Technical Sciences SIMATS, Chennai 600077, India
Interests: synthesis of nanoparticles; microbiological analysis; molecular biology; characterization technique; nanoformulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanobiotechnology is a novel concept and area of nanotechnology that has attracted worldwide interest. Green nanotechnology is the ideal approach to minimize the effects of nanomaterial manufacturing and application while also reducing the risks of problems associated with other methods. The eco-friendly mechanism and low toxicity of the applied and obtained compounds have already helped to radically increase the popularity of the biological synthesis method. In the context of medical use, this means, first of all, the absence of a toxic effect for humans, as well as a targeted effect. Due to their unique physicochemical properties, nanomaterials have received increased attention regarding their use in biological approaches and are capable of opening a new chapter in the treatment of various diseases. The different biological activities can make them indispensable assistants in the fight against diseases of the most diverse origin, such as antibacterial, antiviral, anticancer, anti-inflammatory, insecticidal agents, drug delivery, and other types of diagnostics and therapy. Studying the mechanisms of “biosynthesis” nanomaterials on living cells can not only bring us closer to solving a considerable number of modern medical problems but also expand the application horizons of these amazing objects.

In this Special Issue, we aim to publish studies on the current and potential applications of nanomaterials in biomedical research and practice, agriculture, bioremediation, and other areas, as well as synthesis mechanisms and interaction with living objects, which can become the basis of their potential multipolar application. Both original research papers and review articles are invited.

Dr. Muthu Thiruvengadam
Dr. Govindasamy Rajakumar
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • biosynthesis
  • biomedical application
  • nanoparticles
  • outcome and pathways
  • nanoformulations
  • nanomedicine
  • nanodrug delivery

Published Papers (1 paper)

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Research

16 pages, 3081 KiB  
Article
Antifungal Properties of Biogenic Selenium Nanoparticles Functionalized with Nystatin for the Inhibition of Candida albicans Biofilm Formation
by Shivraj Hariram Nile, Dipalee Thombre, Amruta Shelar, Krithika Gosavi, Jaiprakash Sangshetti, Weiping Zhang, Elwira Sieniawska, Rajendra Patil and Guoyin Kai
Molecules 2023, 28(4), 1836; https://doi.org/10.3390/molecules28041836 - 15 Feb 2023
Cited by 7 | Viewed by 2155
Abstract
In the present study, biogenic selenium nanoparticles (SeNPs) have been prepared using Paenibacillus terreus and functionalized with nystatin (SeNP@PVP_Nystatin nanoconjugates) for inhibiting growth, morphogenesis, and a biofilm in Candida albicans. Ultraviolet–visible spectroscopy analysis has shown a characteristic absorption at 289, 303, and [...] Read more.
In the present study, biogenic selenium nanoparticles (SeNPs) have been prepared using Paenibacillus terreus and functionalized with nystatin (SeNP@PVP_Nystatin nanoconjugates) for inhibiting growth, morphogenesis, and a biofilm in Candida albicans. Ultraviolet–visible spectroscopy analysis has shown a characteristic absorption at 289, 303, and 318 nm, and X-ray diffraction analysis has shown characteristic peaks at different 2θ values for SeNPs. Electron microscopy analysis has shown that biogenic SeNPs are spherical in shape with a size in the range of 220–240 nm. Fourier transform infrared spectroscopy has confirmed the functionalization of nystatin on SeNPs (formation of SeNP@PVP_Nystatin nanoconjugates), and the zeta potential has confirmed the negative charge on the nanoconjugates. Biogenic SeNPs are inactive; however, nanoconjugates have shown antifungal activities on C. albicans (inhibited growth, morphogenesis, and a biofilm). The molecular mechanism for the action of nanoconjugates via a real-time polymerase chain reaction has shown that genes involved in the RAS/cAMP/PKA signaling pathway play an important role in antifungal activity. In cytotoxic studies, nanoconjugates have inhibited only 12% growth of the human embryonic kidney cell line 293 cells, indicating that the nanocomposites are not cytotoxic. Thus, the biogenic SeNPs produced by P. terreus can be used as innovative and effective drug carriers to increase the antifungal activity of nystatin. Full article
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