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New Advances in Deep Eutectic Solvents, 2nd Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Green Chemistry".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1114

Special Issue Editors


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Guest Editor
REQUIMTE/LAQV, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal
Interests: molecular dynamics simulations; density functional theory; ionic liquids; deep eutectic solvents; electric double layer; interface; electrolyte; energy storage
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Guest Editor Assistant
REQUIMTE/LAQV, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal
Interests: deep eutectic solvents; molecular dynamics; force field; electrodeposition; surface; electrode; solvent

Special Issue Information

Dear Colleagues,

In recent years, deep eutectic solvents (DESs) have gained significant attention from both academic and industrial communities. This is of no surprise, as DESs are a promising class of solvents with unique properties and potential applications in various fields. DESs are formed by combining two or more components in a specific ratio to create a eutectic mixture that remains liquid at or near room temperature, which makes them suitable for use as solvents for chemical reactions, separations, extractions, biotechnology, and the synthesis of nanoparticles, biomaterials, and pharmaceuticals.

Attractive properties of DESs, such as low volatility, high thermal stability, and high conductivity, means they can be used as potential electrolytes in energy storage devices, such as batteries and supercapacitors. Recent research has focused on optimizing the properties of DES-based electrolytes to improve the performance and stability of these devices.

Besides that, DESs can be considered “green” substances, as long as they are derived from natural compounds such as sugars, amino acids, and choline chloride. There are reports of DESs showing promise as sustainable alternatives to traditional solvents, as they are biodegradable, non-toxic, and renewable. Thus, they can be used in the extraction and purification of bioactive compounds from natural sources, such as plants and fungi. DESs have been found to effectively extract a wide range of compounds, including flavonoids, alkaloids, and terpenoids. DES-based drug delivery systems also seem to be promising.

Overall, the use of DESs in various fields is an active area of research, and new advances are being made all the time. The unique properties of DESs make them promising candidates for a wide range of applications, and their potential as sustainable and green solvents is particularly exciting.

The topics covered in this Special Issue represent recent findings in the synthesis of new DESs, theirs properties, and application in different fields. Both review and original research articles are welcomed, highlighting the latest developments and future challenges in this rapidly growing field.

Dr. Iuliia V. Voroshylova
Guest Editor

Dr. Elisabete Ferreira
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • green chemistry
  • natural compounds
  • sustainable processes
  • solvents
  • electrolytes
  • extraction

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Published Papers (1 paper)

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Research

12 pages, 1284 KiB  
Article
Green Extraction of Carotenoids from Pumpkin By-Products Using Natural Hydrophobic Deep Eutectic Solvents: Preliminary Insights
by Lucia Sportiello, Emanuele Marchesi, Roberta Tolve and Fabio Favati
Molecules 2025, 30(3), 548; https://doi.org/10.3390/molecules30030548 - 25 Jan 2025
Cited by 2 | Viewed by 931
Abstract
Natural hydrophobic deep eutectic solvents (NaHDESs), composed of natural components like menthol, fatty acids, and organic acids, are sustainable alternatives to conventional solvents for extracting carotenoids from agro-industrial by-products. This study assessed the performance of nine NaHDESs for extracting β-carotene from pumpkin peels, [...] Read more.
Natural hydrophobic deep eutectic solvents (NaHDESs), composed of natural components like menthol, fatty acids, and organic acids, are sustainable alternatives to conventional solvents for extracting carotenoids from agro-industrial by-products. This study assessed the performance of nine NaHDESs for extracting β-carotene from pumpkin peels, identifying DL-menthol/lactic acid (1:2) as the most effective solvent, achieving a yield of 0.823 ± 0.019 mg/mL of β-carotene, corresponding to 93.95% of the yield obtained using acetone. Optimization through Box–Behnken design (BBD) and response surface methodology (RSM) established ideal extraction conditions: a molar ratio of HBA:HBD at 1:4, a solvent-to-sample ratio of 26:1, and an extraction time of 30 min. These conditions maximized β-carotene recovery while minimizing energy consumption and process costs. Using NaHDESs facilitates the valorization of food waste, achieving extraction efficiencies of up to 25.05% of the theoretical carotenoid content in pumpkin peels. Their high performance and environmentally friendly profile underscore the potential of NaHDESs as sustainable alternatives to conventional solvents. Full article
(This article belongs to the Special Issue New Advances in Deep Eutectic Solvents, 2nd Edition)
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