Pharmacological Evaluation and Phytochemical Analysis of Natural Products, 2nd Edition

Dear Colleagues,

Since ancient times, natural products have been integral to human health and wellbeing. Archaeological and historical evidence indicate that humans have relied on natural substances and their derived molecules for therapeutic purposes for more than 60,000 years. Today, natural products—particularly secondary metabolites—and their derivatives remain among the most prolific and promising sources for discovering novel bioactive compounds and developing innovative drugs. Ongoing research about pharmacological, phytochemical profiling, and mechanistic understanding of natural products continues to yield relevant knowledge for the treatment and prevention of diverse human diseases.

This Special Issue aims to highlight recent advances and emerging trends in the phytochemistry and pharmacology of natural products, highlighting their roles in drug discovery, mechanism elucidation, and therapeutic innovation. We particularly encourage submissions that explore bioactivity-guided isolation, structure–activity relationships, molecular docking and in silico analyses, preclinical pharmacological evaluations of natural compounds. Studies that integrate modern analytical techniques, metabolomics, or biotechnological approaches to enhance the understanding or production of bioactive natural metabolites are also welcome.

As Guest Editor, I invite researchers from diverse fields—encompassing chemistry, biology, and pharmacology —to contribute original research articles, short communications, and comprehensive reviews that expand the frontiers of natural product research and its application in modern medicine.

Prof. Dr. Sergio Faloni de Andrade
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.